vol. 22, no. 02http://sedici.unlp.edu.ar:80/handle/10915/1292024-03-28T20:52:23Z2024-03-28T20:52:23ZEstudo morfo-anatômico da raiz de Waltheria douradinha Saint Hilaire (sterculiaceae)Hoelzel, Solange Cristina da Silva MartinsMorel, Ademir FariasZanetti, Gilberto DolejalManfron, Melânia PalermoSchmidt, Cleberhttp://sedici.unlp.edu.ar:80/handle/10915/65872013-10-17T12:02:29Z2003-01-01T00:00:00ZArticulo
Acta Farmacéutica Bonaerense; vol. 22, no. 2
Foi realizada a análise morfo-anatômica da raiz de Waltheria douradinha St. Hil., estabelendose
parâmetros no controle botânico de qualidade da droga. A raiz axial e rugosa, de estrutura poliarca,
apresenta casca esfoliativa em semi-circulos e súber pluriestratificado com paredes anticlinais coincidentes.
O parênquima possui idioblastos com drusas, cristais prismáticos e grãos de areia. Constatou-se a presença
de mucilagens nos raios intraxilemáticos, cardioativos no cilindro central e alcalóides no córtex e cilindro
central.; The morpho-anatomical analysis of the root of Waltheria douradinha St. Hil. was realized, establishing
parameters in the botanical quality control of the drug. The axial and rugose root, of polyarc structure,
presents exfoliative bark in semicircle and multiseriate suber with anticlinals coincident walls. The parenchyma
presents idioblasts with druses, prismatic crystals of calcium oxalate and grains of sand. It was verified the presence
of mucilage in the rays of xylem, cardiac glycosides in the central cylinder and alkaloids in the cortex and
central cylinder.
2003-01-01T00:00:00ZFoi realizada a análise morfo-anatômica da raiz de Waltheria douradinha St. Hil., estabelendose
parâmetros no controle botânico de qualidade da droga. A raiz axial e rugosa, de estrutura poliarca,
apresenta casca esfoliativa em semi-circulos e súber pluriestratificado com paredes anticlinais coincidentes.
O parênquima possui idioblastos com drusas, cristais prismáticos e grãos de areia. Constatou-se a presença
de mucilagens nos raios intraxilemáticos, cardioativos no cilindro central e alcalóides no córtex e cilindro
central.
The morpho-anatomical analysis of the root of Waltheria douradinha St. Hil. was realized, establishing
parameters in the botanical quality control of the drug. The axial and rugose root, of polyarc structure,
presents exfoliative bark in semicircle and multiseriate suber with anticlinals coincident walls. The parenchyma
presents idioblasts with druses, prismatic crystals of calcium oxalate and grains of sand. It was verified the presence
of mucilage in the rays of xylem, cardiac glycosides in the central cylinder and alkaloids in the cortex and
central cylinder.Farmacoeconomia: um instrumento de eficiência para a política de medicamentos do BrasilMota, Daniel MarquesFernandes, María Eneida PortoCoelho, Helena Lutescia Lunahttp://sedici.unlp.edu.ar:80/handle/10915/65862013-10-17T12:02:29Z2003-01-01T00:00:00ZArticulo
Pharmacoeconomy: an instrument of efficiency for the medicine politics of Brazil
Acta Farmacéutica Bonaerense; vol. 22, no. 2
O medicamento do ponto de vista da economia (ciência da escassez) é considerado um bem econômico, pois está disponível em quantidade inferior a que realmente o sistema de saúde necessita ou deseja para satisfazer aos seus provedores e usuários. Os estudos de avaliação econômica, um dos enfoques abordados na Farmacoeconomia, têm sido utilizados por vários países como forma de otimizar eficientemente o uso dos medicamentos nos diferentes níveis de atenção à saúde. O objetivo deste artigo é apresentar uma revisão conceitual sobre Farmacoeconomia, bem como, discutir sua inclusão nas diretrizes definidas como prioritárias pela Política de Medicamentos no Brasil.; From the point of view of the economy (science of scarcity) medicines are considered an economic good, because it is available in an inferior amount to that the health system really needs or desires to satisfy to its suppliers and users. Some countries have used studies of economic evaluation, one of the boarded approaches in pharmacoeconomy, as a form to optimize the use of medicines in the different levels of health care. The objective of this article is to present a conceptual revision about pharmacoeconomy, as well as to argue its inclusion into the priorities of Medicine Policy in Brazil.
2003-01-01T00:00:00ZO medicamento do ponto de vista da economia (ciência da escassez) é considerado um bem econômico, pois está disponível em quantidade inferior a que realmente o sistema de saúde necessita ou deseja para satisfazer aos seus provedores e usuários. Os estudos de avaliação econômica, um dos enfoques abordados na Farmacoeconomia, têm sido utilizados por vários países como forma de otimizar eficientemente o uso dos medicamentos nos diferentes níveis de atenção à saúde. O objetivo deste artigo é apresentar uma revisão conceitual sobre Farmacoeconomia, bem como, discutir sua inclusão nas diretrizes definidas como prioritárias pela Política de Medicamentos no Brasil.
From the point of view of the economy (science of scarcity) medicines are considered an economic good, because it is available in an inferior amount to that the health system really needs or desires to satisfy to its suppliers and users. Some countries have used studies of economic evaluation, one of the boarded approaches in pharmacoeconomy, as a form to optimize the use of medicines in the different levels of health care. The objective of this article is to present a conceptual revision about pharmacoeconomy, as well as to argue its inclusion into the priorities of Medicine Policy in Brazil.Influence of the ageing phenomenon on the low-frequency electrical impedance behaviour of sodium dipirone syrupBrito, Pedro CesarGotter, CarlosMerep, Davidhttp://sedici.unlp.edu.ar:80/handle/10915/65852013-10-17T12:02:29Z2003-01-01T00:00:00ZArticulo
Influencia del fenómeno de envejecimiento en el comportamiento impedancimétrico a baja frecuencia de un jarabe a base de dipirona sódica
Acta Farmacéutica Bonaerense; vol. 22, no. 2
Influencia del Fenómeno de Envejecimiento en el
Comportamiento Impedancimétrico a Baja Frecuencia de un Jarabe a Base de Dipirona Sódica. El comportamiento de la impedancia eléctrica de un jarabe,
cuya droga principal es la dipirona sódica, es estudiado con el fin de analizar la aplicabilidad de la espectroscopía dieléctrica de baja frecuencia para determinar diferencias entre el jarabe original y el producto envejecido. Las mediciones impedancimétricas fueron realizadas en el rango de frecuencias de 20 Hz a 1 MHz utilizando el Analizador
de Impedancia HP 4284A y una celda no comercial para líquidos. Se han realizado mediciones a diferentes
separaciones de electrodos con el fin de minimizar la infuencia del proceso de polarización de electrodos. El envejecimiento de las muestras se ha producido artificialmente a través de un proceso de dilución. Los
resultados obtenidos indican que la técnica de espectroscopía dieléctrica puede ser usada como un buen procedimiento de
control de calidad de medicamentos.; The impedance behavior of a sodium dipirone syrup is studied in order to analyze the applicability of the low-frequency dielectric spectroscopy for determining the differences between a new and an
aged product. The impedance measurements were performed in the frequency range between 20 Hz and 1 MHz, using the Impedance Analyzer Hewlett-Packard HP 4284 A and a non commercial cell for liquids.
Different electrodes separations measures were made in order to get a better insight of the electrode polarization
phenomenon. The ageing phenomenon has been artificially produced by a dilution procedure. The results show that the dielectric technique can be used as a good quality control procedure for medicines.
2003-01-01T00:00:00ZInfluencia del Fenómeno de Envejecimiento en el
Comportamiento Impedancimétrico a Baja Frecuencia de un Jarabe a Base de Dipirona Sódica. El comportamiento de la impedancia eléctrica de un jarabe,
cuya droga principal es la dipirona sódica, es estudiado con el fin de analizar la aplicabilidad de la espectroscopía dieléctrica de baja frecuencia para determinar diferencias entre el jarabe original y el producto envejecido. Las mediciones impedancimétricas fueron realizadas en el rango de frecuencias de 20 Hz a 1 MHz utilizando el Analizador
de Impedancia HP 4284A y una celda no comercial para líquidos. Se han realizado mediciones a diferentes
separaciones de electrodos con el fin de minimizar la infuencia del proceso de polarización de electrodos. El envejecimiento de las muestras se ha producido artificialmente a través de un proceso de dilución. Los
resultados obtenidos indican que la técnica de espectroscopía dieléctrica puede ser usada como un buen procedimiento de
control de calidad de medicamentos.
The impedance behavior of a sodium dipirone syrup is studied in order to analyze the applicability of the low-frequency dielectric spectroscopy for determining the differences between a new and an
aged product. The impedance measurements were performed in the frequency range between 20 Hz and 1 MHz, using the Impedance Analyzer Hewlett-Packard HP 4284 A and a non commercial cell for liquids.
Different electrodes separations measures were made in order to get a better insight of the electrode polarization
phenomenon. The ageing phenomenon has been artificially produced by a dilution procedure. The results show that the dielectric technique can be used as a good quality control procedure for medicines.Nanocápsulas poliméricas secas contendo indometacina: estudo de formulação e de tolerância gastrintestinal em ratosRaffin, Renata PlatcheckObach, Eliane SempeMezzalira, GrazielaPohlmann, Adriana RaffinGuterres, Sílvia Stanisçuaskihttp://sedici.unlp.edu.ar:80/handle/10915/65842013-10-17T12:02:29Z2003-01-01T00:00:00ZArticulo
Dried nanocapsules containing indomethacin: formulation study and gastrointestinal tolerance
evaluation in rats
Acta Farmacéutica Bonaerense; vol. 22, no. 2
Uma matriz 2<sup>3</sup> foi aplicada a formulações de nanocápsulas contendo indometacina, alterandose as concentrações de óleo, polímero e tensioativos em cada formulação. As suspensões foram nebulizadas usando dióxido de silício coloidal como adjuvante de secagem e analisadas quanto ao diâmetro de partícula, morfologia, teor de indometacina e pH. Os pós com menor concentração de óleo apresentaram dois padrões distintos de nanopartículas, enquanto os outros apresentaram apenas estruturas com diâmetros semelhantes aos das nanocápsulas em suspensão. Nebulizados de nanocápsulas, nanoesferas e nanoemulsão, também contendo indometacina foram testados quanto à toxicidade gastrintestinal em ratos. Apenas o nebulizado de nanocápsulas foi eficiente na proteção da mucosa intestinal.; Nanocapsule suspensions containing indomethacin were prepared according to a 2<sup>3</sup> design. The concentrations of the oil phase, the polymer and the surfactants varied at two levels in each formulation. The
suspension were spray-dried using silicon dioxide as drying adjuvant and characterized by size measurements (PCS), morphology, indomethacin content (HPLC) and pH. The powders prepared using low oil concentration presented two patterns of nanoparticles on the microparticle surface, while the other formulations showed similar diameters than those observed in the original colloidal suspension. Spray-dried nanocapsules, nanospheres and nanoemulsion were also evaluated in relation of their gastrointestinal tolerance in rats. Only spray-dried nanocapsules showed an important intestinal mucosa protective effect.
2003-01-01T00:00:00ZUma matriz 2<sup>3</sup> foi aplicada a formulações de nanocápsulas contendo indometacina, alterandose as concentrações de óleo, polímero e tensioativos em cada formulação. As suspensões foram nebulizadas usando dióxido de silício coloidal como adjuvante de secagem e analisadas quanto ao diâmetro de partícula, morfologia, teor de indometacina e pH. Os pós com menor concentração de óleo apresentaram dois padrões distintos de nanopartículas, enquanto os outros apresentaram apenas estruturas com diâmetros semelhantes aos das nanocápsulas em suspensão. Nebulizados de nanocápsulas, nanoesferas e nanoemulsão, também contendo indometacina foram testados quanto à toxicidade gastrintestinal em ratos. Apenas o nebulizado de nanocápsulas foi eficiente na proteção da mucosa intestinal.
Nanocapsule suspensions containing indomethacin were prepared according to a 2<sup>3</sup> design. The concentrations of the oil phase, the polymer and the surfactants varied at two levels in each formulation. The
suspension were spray-dried using silicon dioxide as drying adjuvant and characterized by size measurements (PCS), morphology, indomethacin content (HPLC) and pH. The powders prepared using low oil concentration presented two patterns of nanoparticles on the microparticle surface, while the other formulations showed similar diameters than those observed in the original colloidal suspension. Spray-dried nanocapsules, nanospheres and nanoemulsion were also evaluated in relation of their gastrointestinal tolerance in rats. Only spray-dried nanocapsules showed an important intestinal mucosa protective effect.Toxicidade aguda e atividade antibacteriana dos extratos de Tropaeolum majus L.Zanetti, Gilberto DolejalManfron, Melânia PalermoHoelzel, Solange Cristina da Silva MartinsMorel, Ademir FariasPagliarin, Vera Pereirahttp://sedici.unlp.edu.ar:80/handle/10915/65832013-10-17T12:02:29Z2003-01-01T00:00:00ZArticulo
Acute toxicity and antibacterial activity of Tropaeolum majus L. extracts
Acta Farmacéutica Bonaerense; vol. 22, no. 2
Foi determinada a toxicidade aguda via oral e a ação antibacteriana por bioautografia, frente a bactérias Gram-positivas e Gram-negativas, de extratos de Tropaeolum majus L., planta reconhecida como medicinal. Nao foram observados sinais de toxicidade do extrato aquoso e etanólico 70%. As frações hexânica e clorofórmica do extrato etanólico 70%, apresentaram atividade contra os microrganismos testados.; It was determined the oral acute toxicity and the antibacterial activity by bioautoghaphy against Gram (+) and Gram (-) bacteria of the extracts of Tropaeolum majus L., plant recognized as medicinal. No toxic effects were observed after oral administration of the aqueous and ethanolic 70% extracts. The hexanic and chloroform fractions of the ethanolic extract 70% showed activity against the tested microorganisms.; Foi determinada a toxicidade aguda via oral e a ação antibacteriana por bioautografia, frente a
bactérias Gram-positivas e Gram-negativas, de extratos de Tropaeolum majus L., planta reconhecida como medicinal. Nao foram observados sinais de toxicidade do extrato aquoso e etanólico 70%. As frações hexânica e clorofórmica do extrato etanólico 70%, apresentaram atividade contra os microrganismos testados.
2003-01-01T00:00:00ZFoi determinada a toxicidade aguda via oral e a ação antibacteriana por bioautografia, frente a bactérias Gram-positivas e Gram-negativas, de extratos de Tropaeolum majus L., planta reconhecida como medicinal. Nao foram observados sinais de toxicidade do extrato aquoso e etanólico 70%. As frações hexânica e clorofórmica do extrato etanólico 70%, apresentaram atividade contra os microrganismos testados.
It was determined the oral acute toxicity and the antibacterial activity by bioautoghaphy against Gram (+) and Gram (-) bacteria of the extracts of Tropaeolum majus L., plant recognized as medicinal. No toxic effects were observed after oral administration of the aqueous and ethanolic 70% extracts. The hexanic and chloroform fractions of the ethanolic extract 70% showed activity against the tested microorganisms.
Foi determinada a toxicidade aguda via oral e a ação antibacteriana por bioautografia, frente a
bactérias Gram-positivas e Gram-negativas, de extratos de Tropaeolum majus L., planta reconhecida como medicinal. Nao foram observados sinais de toxicidade do extrato aquoso e etanólico 70%. As frações hexânica e clorofórmica do extrato etanólico 70%, apresentaram atividade contra os microrganismos testados.Atividade citotóxica de <i>Plectranthus barbatus</i> Andr. (Lamiaceae)Caldas Días Costa, Maria do CarmoCarneiro do Nascimento, Silenehttp://sedici.unlp.edu.ar:80/handle/10915/65822018-04-27T18:03:26Z2003-01-01T00:00:00ZArticulo
Cytotoxic activity of Plectranthus barbatus Andr. (Lamiaceae)
Acta Farmacéutica Bonaerense; vol. 22, no. 2
Extratos brutos de raiz, caule e folhas de Plectranthus barbatus Andr. (Lamiaceae), foram testados frente às células NCI-H292 (obtidas de carcinoma mucoepidermóide de pulmão humano) e células HEp 2 (obtidas de carcinoma epidermóide de laringe). Extratos de acetona e de metanol da raiz mostraram atividade significativa frente às células NCI-H292. Células HEp-2 não foram sensíveis aos extratos de P. barbatus. A CI 50 foi determinada a partir de uma regressão linear, relacionandose o percentual de inibição celular em função do logaritmo das concentrações testadas (p<0,01).; Cytotoxic Activity of Plectranthus barbatus Andr. (Lamiaceae). Crude extracts of Plectranthus barbatus Andr. (Lamiaceae) roots, stem and leaves, were tested against cell NCI-H292 (derivated from an pulmonary mucoepidermoid human carcinoma) and cell HEp-2 (derivated from an epidermoid carcinoma of the larynx). Acetonic and methanolic extracts of the roots showed significative activity agains NCI-H292 cell. The cell HEp 2 were not sensitive for P. barbatus extracts. The IC 50 was measured by linear regression, relating celular inhibition rate with tested concentration logarithm (p< 0,01).
2003-01-01T00:00:00ZExtratos brutos de raiz, caule e folhas de Plectranthus barbatus Andr. (Lamiaceae), foram testados frente às células NCI-H292 (obtidas de carcinoma mucoepidermóide de pulmão humano) e células HEp 2 (obtidas de carcinoma epidermóide de laringe). Extratos de acetona e de metanol da raiz mostraram atividade significativa frente às células NCI-H292. Células HEp-2 não foram sensíveis aos extratos de P. barbatus. A CI 50 foi determinada a partir de uma regressão linear, relacionandose o percentual de inibição celular em função do logaritmo das concentrações testadas (p<0,01).
Cytotoxic Activity of Plectranthus barbatus Andr. (Lamiaceae). Crude extracts of Plectranthus barbatus Andr. (Lamiaceae) roots, stem and leaves, were tested against cell NCI-H292 (derivated from an pulmonary mucoepidermoid human carcinoma) and cell HEp-2 (derivated from an epidermoid carcinoma of the larynx). Acetonic and methanolic extracts of the roots showed significative activity agains NCI-H292 cell. The cell HEp 2 were not sensitive for P. barbatus extracts. The IC 50 was measured by linear regression, relating celular inhibition rate with tested concentration logarithm (p< 0,01).Efeito da força e da velocidade de compressão sobre as propriedades de comprimidos contendo alta concentração de extrato seco vegetalSoares, Luiz Alberto LiraSchmidt, Peter ChristianOrtega, George GonzálezPetrovick, Pedro Roshttp://sedici.unlp.edu.ar:80/handle/10915/65812013-10-17T12:02:29Z2003-01-01T00:00:00ZArticulo
Effect of compression force and tablet press speed on the properties of tablets containing highdose of spray dried plant extracts
Acta Farmacéutica Bonaerense; vol. 22, no. 3
O objetivo deste trabalho foi a preparação de comprimidos contendo alta concentração de ex-trato
de Maytenus ilicifolia seco por aspersão. Os comprimidos foram produzidos por compressão direta,
empregando celulose microcristalina, dióxido de silício coloidal e estearato de magnésio como adjuvantes.
As influências da força e da velocidade de compressão sobre as propriedades de dureza, tempo de desinte-gração
e friabilidade foram avaliadas através de metodologia de superfície de resposta. Modelos matemá-ticos
foram ajustados aos dados experimentais e validados. Enquanto as propriedades mecânicas dos com-primidos
tais como dureza e friabilidade foram sensíveis apenas à força aplicada, o tempo de desinte-gração
foi influenciado por ambas variáveis independentes.; The aim of this work was to obtain tablets containing high-dose of spray-dried
extracts from Maytenus ilicifolia. The tablets were prepared by direct compression and cellulose microcrystalline,
colloidal silicon dioxide and magnesium stearate were used as excipients. The influence of compression force and machine speed on the tablets hardness, disintegration time and friability were studied by response surface methodology. Mathematical models were fitted to experimental data and validated. It could observed that
the tablet mechanical properties such as hardness and friability were influenced only by compression force, while
the disintegration time was affected by both independent variables.
2003-01-01T00:00:00ZO objetivo deste trabalho foi a preparação de comprimidos contendo alta concentração de ex-trato
de Maytenus ilicifolia seco por aspersão. Os comprimidos foram produzidos por compressão direta,
empregando celulose microcristalina, dióxido de silício coloidal e estearato de magnésio como adjuvantes.
As influências da força e da velocidade de compressão sobre as propriedades de dureza, tempo de desinte-gração
e friabilidade foram avaliadas através de metodologia de superfície de resposta. Modelos matemá-ticos
foram ajustados aos dados experimentais e validados. Enquanto as propriedades mecânicas dos com-primidos
tais como dureza e friabilidade foram sensíveis apenas à força aplicada, o tempo de desinte-gração
foi influenciado por ambas variáveis independentes.
The aim of this work was to obtain tablets containing high-dose of spray-dried
extracts from Maytenus ilicifolia. The tablets were prepared by direct compression and cellulose microcrystalline,
colloidal silicon dioxide and magnesium stearate were used as excipients. The influence of compression force and machine speed on the tablets hardness, disintegration time and friability were studied by response surface methodology. Mathematical models were fitted to experimental data and validated. It could observed that
the tablet mechanical properties such as hardness and friability were influenced only by compression force, while
the disintegration time was affected by both independent variables.Equivalencia farmacéutica en comprimidos recubiertos de diclofenac sódicoOlivera, María EugeniaAllemandi, Daniel A.Manzo, Rubén H.http://sedici.unlp.edu.ar:80/handle/10915/65802013-10-17T12:02:29Z2003-01-01T00:00:00ZArticulo
Pharmaceutical equivalence of sodium diclofenac delayed-release tablets
Acta Farmacéutica Bonaerense; vol. 22, no. 2
En el marco de un programa de análisis de similitud entre medicamentos, se seleccionaron
comprimidos de diclofenac sódico de 50 mg procedentes de 6 empresas productoras de Argentina, denominados
por los fabricantes como comprimidos recubiertos. La USP 25 codifica los comprimidos de diclofenac sódico como comprimidos de liberación retardada o con recubrimiento entérico. Se realizaron
los ensayos de disolución codificados en la USP con los objetivos de determinar si los comprimidos seleccionados
tienen recubrimiento entérico, si satisfacen o no los requerimientos codificados y si pueden ser denominados como medicamentos similares, de acuerdo a la normativa vigente en el país. Los comprimidos
provenientes de dos de los laboratorios superaron los requisitos codificados y son en consecuencia, comprimidos con cubierta entérica y similares entre sí. Los provenientes de los cuatro restantes no
cumplen con las exigencias codificadas y aunque puede inferirse por los resultados que fueron diseñados como
medicamentos de acción retardada, no pueden ser catalogados como tales. La falta de cumplimiento está vinculada a la pérdida de integridad de la cubierta durante la etapa ácida del ensayo, con la consecuente
transformación de sal sódica en ácido libre, cuya velocidad de disolución es menor.; Pharmaceutical equivalence of sodium diclofenac delayed-release tablets. Sodium diclofenac 50 mg tablets belonging to 6 different Argentinian manufacturers and named as coated tablets, were selected to test them according to USP dissolution requirements. Sodium diclofenac is codified by USP 25 as delayed-release
tablets. The goals were to determine if the test products satisfy USP dissolution requirements and, in consequence,
if they may be regarded as similar drug products according to the argentinian regulations. Results showed that only two products complied the requirements for delayed-release tablets and may be regarded as
similar drug products. The rest did not comply USP requirements. Although it can be inferred from the results that the covers of this set were designed to produce delayed-release, the loss of their integrity during the acid step seems to be the factor that determines the non-compliance with the second step requirements. This behavior may be associated with the conversion of some sodium diclofenac into the free acid during the first step. The last having low water solubility should also exhibit low dissolution rate during the second step.
2003-01-01T00:00:00ZEn el marco de un programa de análisis de similitud entre medicamentos, se seleccionaron
comprimidos de diclofenac sódico de 50 mg procedentes de 6 empresas productoras de Argentina, denominados
por los fabricantes como comprimidos recubiertos. La USP 25 codifica los comprimidos de diclofenac sódico como comprimidos de liberación retardada o con recubrimiento entérico. Se realizaron
los ensayos de disolución codificados en la USP con los objetivos de determinar si los comprimidos seleccionados
tienen recubrimiento entérico, si satisfacen o no los requerimientos codificados y si pueden ser denominados como medicamentos similares, de acuerdo a la normativa vigente en el país. Los comprimidos
provenientes de dos de los laboratorios superaron los requisitos codificados y son en consecuencia, comprimidos con cubierta entérica y similares entre sí. Los provenientes de los cuatro restantes no
cumplen con las exigencias codificadas y aunque puede inferirse por los resultados que fueron diseñados como
medicamentos de acción retardada, no pueden ser catalogados como tales. La falta de cumplimiento está vinculada a la pérdida de integridad de la cubierta durante la etapa ácida del ensayo, con la consecuente
transformación de sal sódica en ácido libre, cuya velocidad de disolución es menor.
Pharmaceutical equivalence of sodium diclofenac delayed-release tablets. Sodium diclofenac 50 mg tablets belonging to 6 different Argentinian manufacturers and named as coated tablets, were selected to test them according to USP dissolution requirements. Sodium diclofenac is codified by USP 25 as delayed-release
tablets. The goals were to determine if the test products satisfy USP dissolution requirements and, in consequence,
if they may be regarded as similar drug products according to the argentinian regulations. Results showed that only two products complied the requirements for delayed-release tablets and may be regarded as
similar drug products. The rest did not comply USP requirements. Although it can be inferred from the results that the covers of this set were designed to produce delayed-release, the loss of their integrity during the acid step seems to be the factor that determines the non-compliance with the second step requirements. This behavior may be associated with the conversion of some sodium diclofenac into the free acid during the first step. The last having low water solubility should also exhibit low dissolution rate during the second step.Vibrational and magnetic properties of a Cu/Mg glutamate complexWagner, Claudia C.Barán, Enrique Joséhttp://sedici.unlp.edu.ar:80/handle/10915/65792013-10-17T12:02:29Z2003-01-01T00:00:00ZArticulo
Propiedades vibracionales y magnéticas de un complejo deCu/Mg con glutamato
Acta Farmacéutica Bonaerense; vol. 22, no. 2
Propiedades Vibracionales y Magnéticas de un Complejo deCu/Mg con Glutamato. El complejo metálico mixto de glutamato recientemente descripto, de estequiometría [CuMg(L-glu)2 (H 2 O)3 ].2H 2 O, fue obtenido en forma de polvo microcristalino de solución acuosa. Su estructua fue confirmada por difracción de rayos X. El espectro de infrarrojo del complejo fue registrado y discutido brevemente en base a sus peculiaridades estructurales. Su comportamiento magnético se investigó a través de mediciones de susceptibilidad magnética en el intervalo de temperaturas entre 2 y 300 K, complementadas con espectros ESR (en bandas Q y X). Estas medidas confirmaron una cierta interacción entre los centros de Cu(II) presentes en la estructura polimérica del compuesto. El estudio se completó con una serie de ensayos de disolución, los que confirmaron la potencial utilidad de este complejo para la suplementación de metales en medicina humana y veterinaria.; The recently reported mixed metal glutamate complex of stoichiometry [CuMg(L-glu) 2 (H 2 O)3 ].2H 2 O was obtained as microcrystalline powder from aqueous solution. Its structure was confirmed by X-ray diffractometry. The infrared spectrum of the complex was recorded and briefly discussed in relation to its structural characteristics. Its magnetic behavior was investigated by magnetic susceptibility measurements in the temperature range between 2 and 300 K, complemented with ESR (Q- and X-band) spectra. These measurements confirmed a certain magnetic interaction between the Cu(II) centers present in the polymeric structure of the compound. The study was completed with a series of dissolution tests, which confirmed the potential usefulness of this complex for metal supplementation in human and veterinary medicine.
2003-01-01T00:00:00ZPropiedades Vibracionales y Magnéticas de un Complejo deCu/Mg con Glutamato. El complejo metálico mixto de glutamato recientemente descripto, de estequiometría [CuMg(L-glu)2 (H 2 O)3 ].2H 2 O, fue obtenido en forma de polvo microcristalino de solución acuosa. Su estructua fue confirmada por difracción de rayos X. El espectro de infrarrojo del complejo fue registrado y discutido brevemente en base a sus peculiaridades estructurales. Su comportamiento magnético se investigó a través de mediciones de susceptibilidad magnética en el intervalo de temperaturas entre 2 y 300 K, complementadas con espectros ESR (en bandas Q y X). Estas medidas confirmaron una cierta interacción entre los centros de Cu(II) presentes en la estructura polimérica del compuesto. El estudio se completó con una serie de ensayos de disolución, los que confirmaron la potencial utilidad de este complejo para la suplementación de metales en medicina humana y veterinaria.
The recently reported mixed metal glutamate complex of stoichiometry [CuMg(L-glu) 2 (H 2 O)3 ].2H 2 O was obtained as microcrystalline powder from aqueous solution. Its structure was confirmed by X-ray diffractometry. The infrared spectrum of the complex was recorded and briefly discussed in relation to its structural characteristics. Its magnetic behavior was investigated by magnetic susceptibility measurements in the temperature range between 2 and 300 K, complemented with ESR (Q- and X-band) spectra. These measurements confirmed a certain magnetic interaction between the Cu(II) centers present in the polymeric structure of the compound. The study was completed with a series of dissolution tests, which confirmed the potential usefulness of this complex for metal supplementation in human and veterinary medicine.Diseño y elaboración de comprimidos de ácido acetilsalicílico de administración sublingual. Evaluación farmacocinética y de la actividad antiagregante plaquetariaPeña, Alberto LuisLufrano, PabloMaurel, Danielhttp://sedici.unlp.edu.ar:80/handle/10915/65782013-10-17T12:02:29Z2003-01-01T00:00:00ZArticulo
Design and production of acetyl salicylic acid sublingual administration tablets. Evaluation of pharmacokinetic
parameters and the antiplatelet aggregation activity
Acta Farmacéutica Bonaerense; vol. 22, no. 2
El presente trabajo tuvo por objeto diseñar y elaborar comprimidos de ácido acetilsalicílico (AAS) de administración sublingual con una baja concentración de principio activo que preserve la actividad antigagregante plaquetaria, pretendiendo hallar por esta vía de administración una alternativa para la
admisión de bajas dosis de AAS. Distintas formulaciones fueron evaluadas farmacocinética y hematológicamente.
El estudio farmacocinético se realizó siguiendo en orina la cantidad acumulada del principal metabolito del AAS durante 30 horas, midiéndose los niveles de salicilato por espectrofotometría a 540 nm. Los
parámetros farmacocinéticos obtenidos fueron analizados estadísticamente mediante el test de ANOVA.
Dos de las formulaciones, A-100 y C-100, mostraron una biodisponibilidad relativa superior con respecto al
fármaco innovador del 11,2 y 11,9%, respectivamente. En base a los parámetros farmacocinéticos estimados y a los resultados de los ensayos de disgregación, fue seleccionada la formulación identificada como C-100 con la finalidad de verificar la actividad antiagregante plaquetaria mediante el método turbidimétrico
de Born y Cross, utilizándose como inductores epinefrina, ADP y colágeno. También se analizó hematológicamente la formulación C-50, a fin de comprobar si la reducción en un 50% del principio activo no altera el
efecto antitrómbico. Los valores de agregación plaquetaria, expresados como % de variación de la transmisión del plasma rico en plaquetas con respecto a la transmisión del plasma pobre en plaquetas, producidos
por los comprimidos elaborados con respecto a los valores basales, demuestran que se produce una notable desagregación plaquetaria, por lo que tienen una aceptable actividad como agente antitrombótico con dosis
mucho más bajas que las requeridas para otras de sus acciones. Como resultado final se propuso el comprimido C-50 para la administración de AAS por vía sublingual. Además demostró un efecto protector en los fenómenos de hiperagregación plaquetaria, experimentados por los buzos cuando descienden a más de 30m de profundidad; la evaluación clínica del uso prolongado del comprimido sublingual elaborado (C-100)
durante 90 días no produjo lesiones sobre la mucosa sublingual, piso de boca y encía lingual.; Design and production of acetyl salicylic acid sublingual administration tablets. Evaluation of pharmacokinetic
parameters and the antiplatelet aggregation activity. The aim of this work was to design and elaborate acetyl salicylic acid (AAS) sublingual administration tablets with a low concentration of active principle but
preserving the antiplatelet aggregation activity, as an alternative administration way for low AAS doses. The formulations were pharmacokinetically and hematologically evaluated. For the pharmakokinetic analysis the formulations were monitored in urine during 30 hours, the salicilate levels being measured spectrophotometrically at 540 nm; a series of pharmacokinetics parameters were statistically analyzed by means of the ANOVA method.
The formulations A-100 and C-100 showed a higher relative biodisposability (11.2 and 11.9% with regard to the innovator, respectively). On the basis of pharmacokinetic parameters and the results of disintegration trials, formulation C-100 was selected with the purpose of verify the antiplatelet aggregation activity by means of the turbidimetric method of Born and Cross, using epinephrine, ADP, and collagen as inductors. Formulation C-50 was also analyzed, in order to check if the reduction in 50% of the active principle doesnt alter the antitrombotic effect.
The values of platelet aggregation, expressed as percentage of variation of the platelet rich plasma transmission
with regard to the platelet poor plasma transmission, showed that the elaborated tablets produce a remarkable platelet aggregation at much lower doses that those required for others pharmacological actions. The C-50 tablet is then proposed for AAS administration by sublingual way, which also demonstrated a protective effect in the
platelet hyperaggregation phenomenon experienced by divers when they descend to more than 30 meters depth.
Clinical evaluation of the lengthy use of C-100 sublingual tablets during 90 days demonstrated no lesions appearance on the sublingual mucous tissue, mouth floor nor lingual mucosa.
2003-01-01T00:00:00ZEl presente trabajo tuvo por objeto diseñar y elaborar comprimidos de ácido acetilsalicílico (AAS) de administración sublingual con una baja concentración de principio activo que preserve la actividad antigagregante plaquetaria, pretendiendo hallar por esta vía de administración una alternativa para la
admisión de bajas dosis de AAS. Distintas formulaciones fueron evaluadas farmacocinética y hematológicamente.
El estudio farmacocinético se realizó siguiendo en orina la cantidad acumulada del principal metabolito del AAS durante 30 horas, midiéndose los niveles de salicilato por espectrofotometría a 540 nm. Los
parámetros farmacocinéticos obtenidos fueron analizados estadísticamente mediante el test de ANOVA.
Dos de las formulaciones, A-100 y C-100, mostraron una biodisponibilidad relativa superior con respecto al
fármaco innovador del 11,2 y 11,9%, respectivamente. En base a los parámetros farmacocinéticos estimados y a los resultados de los ensayos de disgregación, fue seleccionada la formulación identificada como C-100 con la finalidad de verificar la actividad antiagregante plaquetaria mediante el método turbidimétrico
de Born y Cross, utilizándose como inductores epinefrina, ADP y colágeno. También se analizó hematológicamente la formulación C-50, a fin de comprobar si la reducción en un 50% del principio activo no altera el
efecto antitrómbico. Los valores de agregación plaquetaria, expresados como % de variación de la transmisión del plasma rico en plaquetas con respecto a la transmisión del plasma pobre en plaquetas, producidos
por los comprimidos elaborados con respecto a los valores basales, demuestran que se produce una notable desagregación plaquetaria, por lo que tienen una aceptable actividad como agente antitrombótico con dosis
mucho más bajas que las requeridas para otras de sus acciones. Como resultado final se propuso el comprimido C-50 para la administración de AAS por vía sublingual. Además demostró un efecto protector en los fenómenos de hiperagregación plaquetaria, experimentados por los buzos cuando descienden a más de 30m de profundidad; la evaluación clínica del uso prolongado del comprimido sublingual elaborado (C-100)
durante 90 días no produjo lesiones sobre la mucosa sublingual, piso de boca y encía lingual.
Design and production of acetyl salicylic acid sublingual administration tablets. Evaluation of pharmacokinetic
parameters and the antiplatelet aggregation activity. The aim of this work was to design and elaborate acetyl salicylic acid (AAS) sublingual administration tablets with a low concentration of active principle but
preserving the antiplatelet aggregation activity, as an alternative administration way for low AAS doses. The formulations were pharmacokinetically and hematologically evaluated. For the pharmakokinetic analysis the formulations were monitored in urine during 30 hours, the salicilate levels being measured spectrophotometrically at 540 nm; a series of pharmacokinetics parameters were statistically analyzed by means of the ANOVA method.
The formulations A-100 and C-100 showed a higher relative biodisposability (11.2 and 11.9% with regard to the innovator, respectively). On the basis of pharmacokinetic parameters and the results of disintegration trials, formulation C-100 was selected with the purpose of verify the antiplatelet aggregation activity by means of the turbidimetric method of Born and Cross, using epinephrine, ADP, and collagen as inductors. Formulation C-50 was also analyzed, in order to check if the reduction in 50% of the active principle doesnt alter the antitrombotic effect.
The values of platelet aggregation, expressed as percentage of variation of the platelet rich plasma transmission
with regard to the platelet poor plasma transmission, showed that the elaborated tablets produce a remarkable platelet aggregation at much lower doses that those required for others pharmacological actions. The C-50 tablet is then proposed for AAS administration by sublingual way, which also demonstrated a protective effect in the
platelet hyperaggregation phenomenon experienced by divers when they descend to more than 30 meters depth.
Clinical evaluation of the lengthy use of C-100 sublingual tablets during 90 days demonstrated no lesions appearance on the sublingual mucous tissue, mouth floor nor lingual mucosa.Estudio termodinámico del reparto de algunas sulfonamidas entre liposomas de lecitina de huevo y sistemas acuososAvila, Carolina M.Gómez, AlfredoMartínez-Rodríguez, Fleminghttp://sedici.unlp.edu.ar:80/handle/10915/65772013-10-17T12:02:29Z2003-01-01T00:00:00ZArticulo
Thermodynamic study of the partitioning of some sulfonamides in egg lecithin liposome/buffer system
Acta Farmacéutica Bonaerense; vol 22, no. 2
En este trabajo se presentan las funciones termodinámicas relativas a la transferencia de un grupo de sulfonamidas estructuralmente relacionadas, desde medios acuosos hasta vesículas liposomales
obtenidas a partir de lecitina de huevo. En todos los casos estudiados las entalpías y las entropías de transferencia
fueron positivas, por lo cual se concluye que la conducción de este proceso es de naturaleza entrópica, debido probablemente al desorden generado en el interior de las bicapas fosfolipídicas por la acomodación
de las sulfonamidas.; Thermodynamic Study of the Partitioning of Some Sulfonamides in Egg Lecithin Liposome/Buffer
System. The thermodynamic functions relatives to the transfer of some structurally related sulfonamides between
egg-lecithin phospholipid vesicles and aqueous media are presented. In all cases the enthalpies and the entropies
of transfer from water to liposomes were positives; therefore the partitioning of sulfonamides in this system
is driven by entropy, probably due to disorder into the hydrophobic core of bilayers.
2003-01-01T00:00:00ZEn este trabajo se presentan las funciones termodinámicas relativas a la transferencia de un grupo de sulfonamidas estructuralmente relacionadas, desde medios acuosos hasta vesículas liposomales
obtenidas a partir de lecitina de huevo. En todos los casos estudiados las entalpías y las entropías de transferencia
fueron positivas, por lo cual se concluye que la conducción de este proceso es de naturaleza entrópica, debido probablemente al desorden generado en el interior de las bicapas fosfolipídicas por la acomodación
de las sulfonamidas.
Thermodynamic Study of the Partitioning of Some Sulfonamides in Egg Lecithin Liposome/Buffer
System. The thermodynamic functions relatives to the transfer of some structurally related sulfonamides between
egg-lecithin phospholipid vesicles and aqueous media are presented. In all cases the enthalpies and the entropies
of transfer from water to liposomes were positives; therefore the partitioning of sulfonamides in this system
is driven by entropy, probably due to disorder into the hydrophobic core of bilayers.Morfo-anatomia de folhas de maracujá: Passiflora actinia Hooker, PassifloraceaeKurtz, Stella Maris Tessaro FiguraSantos, Cid Aimbiré de MoralesDuarte, Márcia do RocioSato, Mayumi Eliza Otsukahttp://sedici.unlp.edu.ar:80/handle/10915/65762013-10-17T12:02:29Z2003-01-01T00:00:00ZArticulo
Morpho-anatomy of passionflower leaves: Passiflora actinia Hooker, Passifloraceae
Acta Farmacéutica Bonaerense; vol. 22, no. 2
Passiflora actinia Hooker, Passifloraceae, conhecida popularmente como maracujá, é uma espécie escandente, de folhas simples, alternas e estipuladas, com nectários extraflorais, gavinhas e flores vistosas. Na medicina tradicional, as folhas são utilizadas como sedativo e ansiolítico. O presente trabalho teve por objetivo realizar estudo morfo-anatômico foliar dessa planta medicinal, a fim de fornecer subsídios farmacognósticos e taxonômicos. As folhas são ovaladas, de margem lisa, ápice obtuso, base arredondada e limbo inteiro. A epiderme é uniestratificada e revestida por cutícula levemente estriada com cera epicuticular em formato de escamas. Na face abaxial, encontram-se estômatos anomocíticos e células com papilas proeminentes. O mesofilo é dorsiventral e idioblastos contendo drusas de oxalato de cálcio estão presentes no parênquima foliar. A nervura principal é biconvexa e o pecíolo tem contorno circular, sendo que ambos possuem feixes vasculares colaterais, dispostos em anel.; Passiflora actinia Hooker, Passifloraceae, commonly called passionflower, is a climbing species with simple and alternate leaves, presenting stipules, extrafloral nectaries, tendrils and showy flowers. In the traditional medicine, the leaves are used for its sedative and anxiolytic properties. The aim of this work was to study the leaf morphoanatomy of the medicinal plant for pharmacognostic and taxonomic purposes. The leaves are oval shaped, with smooth margins, obtuse apex, rounded base and entire blade. The epidermis is uniseriate, coated by a slightly striated cuticle and epicuticular wax forming a scale pattern. On the lower surface, there are anomocytic stomata and prominent papillose cells. The mesophyll is dorsiventral and idioblasts containing calcium oxalate druses are present in the leaf parenchyma. The midrib is biconvex and the petiole has got round shape, both of them showing collateral vascular bundles, distributed as a ring.
2003-01-01T00:00:00ZPassiflora actinia Hooker, Passifloraceae, conhecida popularmente como maracujá, é uma espécie escandente, de folhas simples, alternas e estipuladas, com nectários extraflorais, gavinhas e flores vistosas. Na medicina tradicional, as folhas são utilizadas como sedativo e ansiolítico. O presente trabalho teve por objetivo realizar estudo morfo-anatômico foliar dessa planta medicinal, a fim de fornecer subsídios farmacognósticos e taxonômicos. As folhas são ovaladas, de margem lisa, ápice obtuso, base arredondada e limbo inteiro. A epiderme é uniestratificada e revestida por cutícula levemente estriada com cera epicuticular em formato de escamas. Na face abaxial, encontram-se estômatos anomocíticos e células com papilas proeminentes. O mesofilo é dorsiventral e idioblastos contendo drusas de oxalato de cálcio estão presentes no parênquima foliar. A nervura principal é biconvexa e o pecíolo tem contorno circular, sendo que ambos possuem feixes vasculares colaterais, dispostos em anel.
Passiflora actinia Hooker, Passifloraceae, commonly called passionflower, is a climbing species with simple and alternate leaves, presenting stipules, extrafloral nectaries, tendrils and showy flowers. In the traditional medicine, the leaves are used for its sedative and anxiolytic properties. The aim of this work was to study the leaf morphoanatomy of the medicinal plant for pharmacognostic and taxonomic purposes. The leaves are oval shaped, with smooth margins, obtuse apex, rounded base and entire blade. The epidermis is uniseriate, coated by a slightly striated cuticle and epicuticular wax forming a scale pattern. On the lower surface, there are anomocytic stomata and prominent papillose cells. The mesophyll is dorsiventral and idioblasts containing calcium oxalate druses are present in the leaf parenchyma. The midrib is biconvex and the petiole has got round shape, both of them showing collateral vascular bundles, distributed as a ring.Aislamiento de esteroles, bases de amonio y saponinas de Amaranthus muricatus (Moquin)Gillies ex Hicken (Amaranthaceae)López de Ruiz, Rosa EveliaSilva, Raúl AlejandroRuiz, Sohar Osvaldohttp://sedici.unlp.edu.ar:80/handle/10915/65752013-10-17T12:02:29Z2003-01-01T00:00:00ZArticulo
Isolation of steroids, ammonium bases and saponines of Amaranthus muricatus (Moquin) Gillies
ex Hicken (Amaranthaceae)
Acta Farmacéutica Bonaerense; vol. 22, no. 2
Amaranthus muricatus (Moquin) Gillies ex Hicken (Amaranthaceae), de nombre común yer-ba meona, paiquillo o ataco es usado en la medicina popular como diurético, laxante, emoliente y en cataplasma para hacer supurar las infecciones de la piel. En un trabajo anterior informamos sobre la presencia
de antraquinonas y de flavonoides. En el presente se da cuenta sobre el aislamiento de esteroles y de bases de amonio, en la parte aérea de la planta, aplicando la técnica de extracción con solventes de polaridad creciente. De esa manera en el extracto de éter de petróleo se aislaron tres esteroles (B-sitosterol, estigmasterol y campesterol) y del estracto obtenido con metanol-agua se aislaron dos bases de amonio identificadas como colina y acetilcolina. Por otra parte se logró el ailamiento de dos saponinas, cuya genina es en ambos casos el ácido oleanólico y los azúcares en una de ellas es un disacárido (glucosa y ramnosa) y en el otro un monosacárido (ramnosa).; Isolation of Steroids, Ammonium Bases and Saponines of Amaranthus muricatus (Moquin) Gillies ex Hicken (Amaranthaceae). Amaranthus muricatus (Moquin) Gillies ex Hicken (Amaranthaceae), commonly
known in Argentina as yerba meona, paiquillo o ataco, is a plant used in popular medicine as diuretic, laxative, emollient and as poultice for suppurate skin infections. In a previous work we informed about the isolation of anthraquinones and flavonoids. In the present work we report the presence of three steroids in the aerial
parts, and two ammonium bases isolated by increasing solvent polarity. In the petroleum light extract we isolated
three sterols (B-sitosterol, estigmasterol y campesterol). In the methanol-water extract we isolated two ammonium bases identified as choline and acetylcholine. In the other hand we isolated two saponins which genuine was identified as oleanolic acid and the sugars were in one case a disaccharide (glucose and rhamnose) and the other case monosaccharide (ramnose).
2003-01-01T00:00:00ZAmaranthus muricatus (Moquin) Gillies ex Hicken (Amaranthaceae), de nombre común yer-ba meona, paiquillo o ataco es usado en la medicina popular como diurético, laxante, emoliente y en cataplasma para hacer supurar las infecciones de la piel. En un trabajo anterior informamos sobre la presencia
de antraquinonas y de flavonoides. En el presente se da cuenta sobre el aislamiento de esteroles y de bases de amonio, en la parte aérea de la planta, aplicando la técnica de extracción con solventes de polaridad creciente. De esa manera en el extracto de éter de petróleo se aislaron tres esteroles (B-sitosterol, estigmasterol y campesterol) y del estracto obtenido con metanol-agua se aislaron dos bases de amonio identificadas como colina y acetilcolina. Por otra parte se logró el ailamiento de dos saponinas, cuya genina es en ambos casos el ácido oleanólico y los azúcares en una de ellas es un disacárido (glucosa y ramnosa) y en el otro un monosacárido (ramnosa).
Isolation of Steroids, Ammonium Bases and Saponines of Amaranthus muricatus (Moquin) Gillies ex Hicken (Amaranthaceae). Amaranthus muricatus (Moquin) Gillies ex Hicken (Amaranthaceae), commonly
known in Argentina as yerba meona, paiquillo o ataco, is a plant used in popular medicine as diuretic, laxative, emollient and as poultice for suppurate skin infections. In a previous work we informed about the isolation of anthraquinones and flavonoids. In the present work we report the presence of three steroids in the aerial
parts, and two ammonium bases isolated by increasing solvent polarity. In the petroleum light extract we isolated
three sterols (B-sitosterol, estigmasterol y campesterol). In the methanol-water extract we isolated two ammonium bases identified as choline and acetylcholine. In the other hand we isolated two saponins which genuine was identified as oleanolic acid and the sugars were in one case a disaccharide (glucose and rhamnose) and the other case monosaccharide (ramnose).