vol. 23, no. 04http://sedici.unlp.edu.ar:80/handle/10915/1352024-03-19T05:40:44Z2024-03-19T05:40:44ZInterações farmacocinéticas entre as plantas medicinais Hypericum perforatum, Gingko bilobae Panax gingseng e fármacos tradicionaisde Oliveira, Ana ElisaDalla Costa, Teresahttp://sedici.unlp.edu.ar:80/handle/10915/67032013-10-17T12:02:29Z2004-01-01T00:00:00ZRevision
Pharmacokinetic interactions between herbal medicines and drugs
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Como o uso de plantas medicinais tem se popularizado, sendo comum sua utilização como
complemento aos tratamentos convencionais, a falta de conhecimento sobre interações entre fármacos e
plantas medicinais põem em risco a saúde dos usuários. Neste artigo é apresentada uma revisão de literatura
sobre interações farmacocinéticas entre fármacos e plantas medicinais utilizadas no Brasil como Hypericum
perforatum, Gingko biloba e Panax ginseng. O ajuste da dose recomendada do fármaco durante a
utilização em associação com plantas medicinais, para evitar intoxicações ou concentrações sub-terapêuticas,
quando a utilização da planta for pertinente, pode ser uma alternativa para garantir a eficácia e segurança
do fármaco prescrito.; With the popularization of
the use of herbal medicine it became common to find patients who use herbal medicine as complementary treatment
to conventional drugs. The lack of knowledge about the potential risks due to interactions between drugs
and herbal medicines is potentially hazardous to the patients. This article brings a literature review on pharmacokinetic
interactions between drugs and commonly herbal plant used in Brazil such as Hypericum perforatum,
Gingko biloba and Panax ginseng. Because the interactions reported in this paper are pharmacokinetic related,
drug dosing adjustments during herb-drug combined use, assuming that the herbal medicine use is adequate,
could be viewed as an alternative solution to warrant drug efficacy and safety.
2004-01-01T00:00:00ZComo o uso de plantas medicinais tem se popularizado, sendo comum sua utilização como
complemento aos tratamentos convencionais, a falta de conhecimento sobre interações entre fármacos e
plantas medicinais põem em risco a saúde dos usuários. Neste artigo é apresentada uma revisão de literatura
sobre interações farmacocinéticas entre fármacos e plantas medicinais utilizadas no Brasil como Hypericum
perforatum, Gingko biloba e Panax ginseng. O ajuste da dose recomendada do fármaco durante a
utilização em associação com plantas medicinais, para evitar intoxicações ou concentrações sub-terapêuticas,
quando a utilização da planta for pertinente, pode ser uma alternativa para garantir a eficácia e segurança
do fármaco prescrito.
With the popularization of
the use of herbal medicine it became common to find patients who use herbal medicine as complementary treatment
to conventional drugs. The lack of knowledge about the potential risks due to interactions between drugs
and herbal medicines is potentially hazardous to the patients. This article brings a literature review on pharmacokinetic
interactions between drugs and commonly herbal plant used in Brazil such as Hypericum perforatum,
Gingko biloba and Panax ginseng. Because the interactions reported in this paper are pharmacokinetic related,
drug dosing adjustments during herb-drug combined use, assuming that the herbal medicine use is adequate,
could be viewed as an alternative solution to warrant drug efficacy and safety.Nanoemulsões como sistemas de liberação para fármacos oftálmicosFronza, TassianaCampos, ÁngelaTeixeira, Helderhttp://sedici.unlp.edu.ar:80/handle/10915/67022013-10-17T12:02:29Z2004-01-01T00:00:00ZRevision
Nanoemulsions as delivery systems for ophthalmic drugs
Acta Farmacéutica Bonaerense; vol. 23, no. 4
A instilação tópica de colírios no saco conjuntival inferior é o procedimento mais correntemente empregado para a administração de fármacos oftálmicos. Entretanto, um dos maiores problemas encontrados com a administração de colírios é a sua rápida eliminação da área pré-corneal através dos mecanismos de proteção do olho, resultando em uma reduzida biodisponibilidade dos fármacos veiculados. O
uso de nanoemulsões lipídicas óleo em água tem sido considerado como uma estratégia promissora para
melhorar a biodisponibilidade de fármacos oftálmicos aplicados topicamente. Assim, o objetivo deste trabalho
é revisar diferentes aspectos relacionados com a composição, técnicas de preparação e propriedades
físico-químicas de nanoemulsões como sistemas de liberação de fármacos oftálmicos. A influência das nanoemulsões em aspectos biofarmacêuticos da ciclosporina A, indometacina e pilocarpina também é discutida.; Topical instillation of eye drops into the lower cul-de-sac is the most common method for the administration of the ophthalmic drugs. However, one of the major problem encountered with eye drops is the rapid and extensive elimination of drugs from the precorneal area by the protection mechanisms of the eye, resulting in a poor bioavailability. The use of lipid nanoemulsions has been considered as a promising strategy to improve the bioavailability of ophthalmic drugs instilled
topically. Therefore, the objective of this review is to present different aspects related to composition, preparation methods and physicochemical properties of the nanoemulsions in ophthalmic delivery systems. The influence of nanoemulsions on biopharmaceutic aspects of cyclosporin A, indomethacin and pilocarpine is also discussed.
2004-01-01T00:00:00ZA instilação tópica de colírios no saco conjuntival inferior é o procedimento mais correntemente empregado para a administração de fármacos oftálmicos. Entretanto, um dos maiores problemas encontrados com a administração de colírios é a sua rápida eliminação da área pré-corneal através dos mecanismos de proteção do olho, resultando em uma reduzida biodisponibilidade dos fármacos veiculados. O
uso de nanoemulsões lipídicas óleo em água tem sido considerado como uma estratégia promissora para
melhorar a biodisponibilidade de fármacos oftálmicos aplicados topicamente. Assim, o objetivo deste trabalho
é revisar diferentes aspectos relacionados com a composição, técnicas de preparação e propriedades
físico-químicas de nanoemulsões como sistemas de liberação de fármacos oftálmicos. A influência das nanoemulsões em aspectos biofarmacêuticos da ciclosporina A, indometacina e pilocarpina também é discutida.
Topical instillation of eye drops into the lower cul-de-sac is the most common method for the administration of the ophthalmic drugs. However, one of the major problem encountered with eye drops is the rapid and extensive elimination of drugs from the precorneal area by the protection mechanisms of the eye, resulting in a poor bioavailability. The use of lipid nanoemulsions has been considered as a promising strategy to improve the bioavailability of ophthalmic drugs instilled
topically. Therefore, the objective of this review is to present different aspects related to composition, preparation methods and physicochemical properties of the nanoemulsions in ophthalmic delivery systems. The influence of nanoemulsions on biopharmaceutic aspects of cyclosporin A, indomethacin and pilocarpine is also discussed.Las microemulsiones como vehículos para administración de drogasCarlucci, Adriana M.Cicconi Vidal, MartaBregni, Carloshttp://sedici.unlp.edu.ar:80/handle/10915/67012013-10-17T12:02:29Z2004-01-01T00:00:00ZContribucion a revista
Microemulsions used as vehicles for administration of drugs
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Las microemulsiones son mezclas isotrópicas, estables, claras, constituidas por una fase oleosa,
una acuosa y uno o más anfifílicos. Despiertan interés a nivel farmacéutico debido a varias ventajas
que ofrecen: capacidad de incorporar un amplio rango de moléculas de principios activos con mejoramiento
de la biodisponibilidad, ser de fácil preparación y de excelente estabilidad. El objetivo del presente
trabajo es revisar la literatura existente hasta el momento en el tema en cuanto a clasificación, ventajas,
caracterización, y formulaciones propuestas para utilizar estos sistemas como vehículos de drogas, haciendo
énfasis en la vía oral y transdermal.; Microemulsions are defined as "a
system of water, oil and one or more amphiphilic molecules which is a single optically isotropic and thermodynamically
stable liquid solution". They awake an important interest in pharmaceutical technology because of
their advantages, such as ability for incorporating a wide range of active compounds and enhancement of their
bioavailability, easy preparation and excellent stability behaviour. The objective of the present work is to review
the present literature about the subject including classification, advantages, characterization and proposed formulations
in order to use these kind of systems as drug vehicles, with particular emphasis being placed on oral and
transdermal route.
2004-01-01T00:00:00ZLas microemulsiones son mezclas isotrópicas, estables, claras, constituidas por una fase oleosa,
una acuosa y uno o más anfifílicos. Despiertan interés a nivel farmacéutico debido a varias ventajas
que ofrecen: capacidad de incorporar un amplio rango de moléculas de principios activos con mejoramiento
de la biodisponibilidad, ser de fácil preparación y de excelente estabilidad. El objetivo del presente
trabajo es revisar la literatura existente hasta el momento en el tema en cuanto a clasificación, ventajas,
caracterización, y formulaciones propuestas para utilizar estos sistemas como vehículos de drogas, haciendo
énfasis en la vía oral y transdermal.
Microemulsions are defined as "a
system of water, oil and one or more amphiphilic molecules which is a single optically isotropic and thermodynamically
stable liquid solution". They awake an important interest in pharmaceutical technology because of
their advantages, such as ability for incorporating a wide range of active compounds and enhancement of their
bioavailability, easy preparation and excellent stability behaviour. The objective of the present work is to review
the present literature about the subject including classification, advantages, characterization and proposed formulations
in order to use these kind of systems as drug vehicles, with particular emphasis being placed on oral and
transdermal route.Reacción cutánea severa a drogas: síndrome de Stevens-Johnson y necrólisis epidérmica tóxicaStaneloni, Maria CeliaMaffione, LeonardoGreco, AnalíaLongarini, ValeriaSantucci, ClaudiaHermilla, VirginiaMartín, MiriamBasilio, VivianaMatteo, PaulaYanivello, VanessaGoyeneche, BeatrizFilinger, Ester Juliahttp://sedici.unlp.edu.ar:80/handle/10915/67002013-10-17T12:02:29Z2004-01-01T00:00:00ZArticulo
Serious cutaneous reaction to drugs: Stevens-Johnson and epidermical toxic necrolisis syndromes
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Las reacciones adversas severas a drogas en piel pueden dar lugar a la muerte. La necrólisis epidérmica tóxica (NET) o síndrome de Lyell tiene la mortalidad más alta (30-35%). El síndrome de Stevens- Johnson es una variante de esta enfermedad, pero con una pérdida menos extensa de la piel y una mortalidad más baja (1-5%). Las reacciones adversas a drogas son enfermedades autolimitadas por lo tanto, el tratamiento es generalmente sintomático. Un rápido diagnóstico, identificación y el retiro temprano de todas las drogas sospechadas, es de prioridad al comienzo de la enfermedad. El cuidado de los pacientes debe hacerse en unidades de cuidado intensivo especializadas, con el mismo tipo de terapia que para quemados: corrección del medio interno, la administración enteral de altas calorías y prevención de sepsis. La eficacia de las drogas usadas en el tratamiento de estas enfermedades es difícil de evaluar: se han utilizado inmunoglobulinas endovenosas, ciclosporina, ciclofosfamida y talidomida. El uso de corticoides es discutido y probablemente es deletéreo en la fase tardía del NET. El cuidado especializado por parte de enfermería y un adecuado tratamiento tópico permite una re-epitelización más rápida de las lesiones de la piel. Un caso clínico se presenta al finalizar el trabajo.; Severe skin adverse drug reactions can result in death. Toxic epidermal necrolysis (TEN) or Lyell Syndrome has the highest mortality (30-35 %). Stevens Johnson syndrome corresponds to the same syndrome, but with less extensive skin detachment and a lowest mortality (1-5%). Drug reactions are self-limited diseases and therefore treatment is generally symptomatic. A prompt diagnosis identification and early withdrawal of all suspect drugs are the most important preliminaries. The management of the patients must be undertaken in specialized intensive care units, with the same types of therapy as for burns: warning of the environment, correction of the electrolyte disturbances, administration of a high caloric enteral intake, and prevention of sepsis. It is difficult to evaluate the efficacy of drugs used in same case reports: intravenous immunoglobulins, cyclosporin, cyclophosphamide and thalidomide have all been tried. Corticosteroid use is debated and is probably deleterious in late forms of TEN. Specific nursing care and adequate topical management reduce associated morbility and allow a more rapid re-epithelialization of skin lesions. A clinical case is reported at the end of this paper.
2004-01-01T00:00:00ZLas reacciones adversas severas a drogas en piel pueden dar lugar a la muerte. La necrólisis epidérmica tóxica (NET) o síndrome de Lyell tiene la mortalidad más alta (30-35%). El síndrome de Stevens- Johnson es una variante de esta enfermedad, pero con una pérdida menos extensa de la piel y una mortalidad más baja (1-5%). Las reacciones adversas a drogas son enfermedades autolimitadas por lo tanto, el tratamiento es generalmente sintomático. Un rápido diagnóstico, identificación y el retiro temprano de todas las drogas sospechadas, es de prioridad al comienzo de la enfermedad. El cuidado de los pacientes debe hacerse en unidades de cuidado intensivo especializadas, con el mismo tipo de terapia que para quemados: corrección del medio interno, la administración enteral de altas calorías y prevención de sepsis. La eficacia de las drogas usadas en el tratamiento de estas enfermedades es difícil de evaluar: se han utilizado inmunoglobulinas endovenosas, ciclosporina, ciclofosfamida y talidomida. El uso de corticoides es discutido y probablemente es deletéreo en la fase tardía del NET. El cuidado especializado por parte de enfermería y un adecuado tratamiento tópico permite una re-epitelización más rápida de las lesiones de la piel. Un caso clínico se presenta al finalizar el trabajo.
Severe skin adverse drug reactions can result in death. Toxic epidermal necrolysis (TEN) or Lyell Syndrome has the highest mortality (30-35 %). Stevens Johnson syndrome corresponds to the same syndrome, but with less extensive skin detachment and a lowest mortality (1-5%). Drug reactions are self-limited diseases and therefore treatment is generally symptomatic. A prompt diagnosis identification and early withdrawal of all suspect drugs are the most important preliminaries. The management of the patients must be undertaken in specialized intensive care units, with the same types of therapy as for burns: warning of the environment, correction of the electrolyte disturbances, administration of a high caloric enteral intake, and prevention of sepsis. It is difficult to evaluate the efficacy of drugs used in same case reports: intravenous immunoglobulins, cyclosporin, cyclophosphamide and thalidomide have all been tried. Corticosteroid use is debated and is probably deleterious in late forms of TEN. Specific nursing care and adequate topical management reduce associated morbility and allow a more rapid re-epithelialization of skin lesions. A clinical case is reported at the end of this paper.Problemas relacionados com medicamentos em serviço de emergência de hospital universitário do Sul do Brasil. Estudo pilotoAndreazza Dall Agnol, Roberta SimoneVicentini Albring, DanielaSilveira de Castro, MauroHeineck, Isabelahttp://sedici.unlp.edu.ar:80/handle/10915/66992013-10-17T12:02:29Z2004-01-01T00:00:00ZArticulo
Drug-related problems in the emergency department of an academical hospital in Southern Brazil. Pilot study
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Problemas Relacionados com Medicamentos (PRM) são problemas de saúde vinculados à terapêutica
farmacológica do paciente e que interferem ou podem interferir nos resultados de saúde esperados.
O presente trabalho relata a etapa de adequação de um instrumento de pesquisa utilizado posteriormente
em estudo sobre PRM em Serviço de Emergência (SE) de um hospital. Nos 48 pacientes analisados
(30 mulheres e 18 homens), observaram-se 18 (37,5%) PRM, sendo 12 relacionados à efetividade, conforme
o Consenso de Granada (2002). Os PRM foram mais freqüentes entre pacientes polimedicados e com
65 anos ou mais. Os dados encontrados sugerem que uma importante parcela dos pacientes que procuram
o SE do Hospital de Clinicas de Porto Alegre o faz por PRM.; Drug-Related Problems (DRP) are health problems linked to the patient?s pharmacological
therapeutics and that interfere or can interfere in the expected health results. The present work describes the stage
of adaptation of a research instrument used later in study on DRP in the Emergency Department (ED) of a hospital.
In the 48 analyzed patients (30 women and 18 men), 18 patients (37,5%) presented DRP, 12 of them were related
to the effectiveness, according to the Consenso de Granada (2002). DRP were more frequent among patient
polymedicated and with 65 years old or more. The data found suggest that an important number of the patients
that look for the ER of Hospital de Clinicas de Porto Alegre do it for DRP.
2004-01-01T00:00:00ZProblemas Relacionados com Medicamentos (PRM) são problemas de saúde vinculados à terapêutica
farmacológica do paciente e que interferem ou podem interferir nos resultados de saúde esperados.
O presente trabalho relata a etapa de adequação de um instrumento de pesquisa utilizado posteriormente
em estudo sobre PRM em Serviço de Emergência (SE) de um hospital. Nos 48 pacientes analisados
(30 mulheres e 18 homens), observaram-se 18 (37,5%) PRM, sendo 12 relacionados à efetividade, conforme
o Consenso de Granada (2002). Os PRM foram mais freqüentes entre pacientes polimedicados e com
65 anos ou mais. Os dados encontrados sugerem que uma importante parcela dos pacientes que procuram
o SE do Hospital de Clinicas de Porto Alegre o faz por PRM.
Drug-Related Problems (DRP) are health problems linked to the patient?s pharmacological
therapeutics and that interfere or can interfere in the expected health results. The present work describes the stage
of adaptation of a research instrument used later in study on DRP in the Emergency Department (ED) of a hospital.
In the 48 analyzed patients (30 women and 18 men), 18 patients (37,5%) presented DRP, 12 of them were related
to the effectiveness, according to the Consenso de Granada (2002). DRP were more frequent among patient
polymedicated and with 65 years old or more. The data found suggest that an important number of the patients
that look for the ER of Hospital de Clinicas de Porto Alegre do it for DRP.Custos envolvidos no tratamento de crianças infectadas pelo HIV/aids no município de São LuísSilva Monteiro, María das GraçasSudo, Elisa CazueOliveira Marques, Robelma France deMarques Mota, Danielhttp://sedici.unlp.edu.ar:80/handle/10915/66982013-10-17T12:02:29Z2004-01-01T00:00:00ZArticulo
Costs involved in the treatment of infected children by HIV/AIDS in a municipality of São Luís-Maranhão (Brazil)
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Estimou-se o custo (direto e indireto) do tratamento de 19 crianças infectadas pelo HIV por
transmissão vertical, entre julho/2001 e junho/2002. Trata-se de um estudo descritivo, na área de farmacoeconomia,
do tipo custo-enfermidade (custo de prevalência) realizado em São Luís - Maranhão (Brasil). O
custo total do tratamento da doença foi de R$ 84.965,59, sendo os medicamentos o item mais oneroso
(88,6%), seguido do custo das consultas (3,0%). O custo por paciente em uso de dupla e tripla terapia antiretroviral
foi de R$ 1.660,33 e R$ 5.308,40, respectivamente. Percebe-se o imenso volume de recursos
econômicos empregados no tratamento dessa enfermidade, principalmente, envolvendo o uso de fármacos.; It was estimated the cost (direct and indirect) of the treatment of 19 children infected by
HIV by vertical transmission, between July/2001 and June/2002. This is a descriptive study, in the pharmacoeconomy
area, in a cost-illness kind carried out in São Luís-Maranhão (Brazil). The total treatment cost of the
illness was R$ 84.965,59, the medicines were the most expensive item (88,6%), followed by the cost of consultation
(3,0%). The cost per patient using double or triple anti-retroviral therapy was R$ 1.660,33 and R$ 5.308,40,
respectively. It is realized the great amount of money spent in the treatment of this illness mainly, involving the
use of medicines.
2004-01-01T00:00:00ZEstimou-se o custo (direto e indireto) do tratamento de 19 crianças infectadas pelo HIV por
transmissão vertical, entre julho/2001 e junho/2002. Trata-se de um estudo descritivo, na área de farmacoeconomia,
do tipo custo-enfermidade (custo de prevalência) realizado em São Luís - Maranhão (Brasil). O
custo total do tratamento da doença foi de R$ 84.965,59, sendo os medicamentos o item mais oneroso
(88,6%), seguido do custo das consultas (3,0%). O custo por paciente em uso de dupla e tripla terapia antiretroviral
foi de R$ 1.660,33 e R$ 5.308,40, respectivamente. Percebe-se o imenso volume de recursos
econômicos empregados no tratamento dessa enfermidade, principalmente, envolvendo o uso de fármacos.
It was estimated the cost (direct and indirect) of the treatment of 19 children infected by
HIV by vertical transmission, between July/2001 and June/2002. This is a descriptive study, in the pharmacoeconomy
area, in a cost-illness kind carried out in São Luís-Maranhão (Brazil). The total treatment cost of the
illness was R$ 84.965,59, the medicines were the most expensive item (88,6%), followed by the cost of consultation
(3,0%). The cost per patient using double or triple anti-retroviral therapy was R$ 1.660,33 and R$ 5.308,40,
respectively. It is realized the great amount of money spent in the treatment of this illness mainly, involving the
use of medicines.Desarrollo y validación del análisis cuantitativo de Ibuprofeno en comprimidos por espectroscopía infrarrojaMatkovic, Silvana R.Valle, Graciela M.Galle, MarianelaBriand, Laura Estefaníahttp://sedici.unlp.edu.ar:80/handle/10915/66972020-07-23T00:40:38Z2004-01-01T00:00:00ZArticulo
Development and validation of the quantitative analysis of Ibuprofen in tablets by RI spectroscopy
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Se desarrolló y validó un método para cuantificar ibuprofeno en comprimidos a través de espectroscopía infrarroja. El método consiste en la extracción del principio activo por disolución en cloroformo y la determinación del área de la banda infrarroja del grupo carbonilo que está centrada en 1721.5 cm<sup>-1</sup>. Se investigó la selectividad, linealidad, límites de detección, precisión y exactitud de la curva de calibración, la extracción de ibuprofeno, el análisis espectroscópico y el tratamiento de datos, a los fines de validar el método analítico. Adicionalmente, los resultados estadísticos se contrastaron con los obtenidos en la cuantificación de ibuprofeno por espectroscopía UV. Los valores de recuperación obtenidos en el análisis de medicamentos nacionales se encuentran entre 98 y 100%.; The quantification of ibuprofen through infrared spectroscopy was developed and validated for pharmaceuticals in tablets. The method involves the extraction of the active ingredient with chloroform and the measurement of the area of the band corresponding to the carbonyl group centered at 1721.5 cm<sup>-1</sup>. Selectivity, linearity, detection limits, precision and accuracy of the calibration curve, as well as ibuprofen extraction, spectroscopic analysis and data manipulation were determined in order to validate the method. Moreover, the statistical results were compared with the quantification of ibuprofen through UV detection. The recovery values obtained in the analysis of pharmaceuticals were in the 98-100% range.
2004-01-01T00:00:00ZSe desarrolló y validó un método para cuantificar ibuprofeno en comprimidos a través de espectroscopía infrarroja. El método consiste en la extracción del principio activo por disolución en cloroformo y la determinación del área de la banda infrarroja del grupo carbonilo que está centrada en 1721.5 cm<sup>-1</sup>. Se investigó la selectividad, linealidad, límites de detección, precisión y exactitud de la curva de calibración, la extracción de ibuprofeno, el análisis espectroscópico y el tratamiento de datos, a los fines de validar el método analítico. Adicionalmente, los resultados estadísticos se contrastaron con los obtenidos en la cuantificación de ibuprofeno por espectroscopía UV. Los valores de recuperación obtenidos en el análisis de medicamentos nacionales se encuentran entre 98 y 100%.
The quantification of ibuprofen through infrared spectroscopy was developed and validated for pharmaceuticals in tablets. The method involves the extraction of the active ingredient with chloroform and the measurement of the area of the band corresponding to the carbonyl group centered at 1721.5 cm<sup>-1</sup>. Selectivity, linearity, detection limits, precision and accuracy of the calibration curve, as well as ibuprofen extraction, spectroscopic analysis and data manipulation were determined in order to validate the method. Moreover, the statistical results were compared with the quantification of ibuprofen through UV detection. The recovery values obtained in the analysis of pharmaceuticals were in the 98-100% range.Estudio fitoquímico de flores de Geoffroea decorticans (Gill. ex Hook. et Arm.) Burk, Leguminoseae (Fabaceae)Silva, Raúl AlejandroLópez de Ruiz, Rosa EveliaRuiz, Sohar Osvaldohttp://sedici.unlp.edu.ar:80/handle/10915/66962013-10-17T12:02:29Z2004-01-01T00:00:00ZComunicacion
Phytochemical study of Geoffroea decorticans (Gill. ex Hook. et Arm.) Burk, Leguminoseae (Fabaceae) flowers
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Geoffroea decorticans (Gill ex Hook et Arn) Burk. Leguminoseae (Fabaceae), de nombre común
"chañar" o "chañarcillo", es un árbol o arbusto de amplia distribución en la República Argentina y
se usa en la medicina popular por sus virtudes emolientes, balsámicas, antitusivas y expectorantes. Aplicando
la técnica de extracción con solventes de polaridad creciente fue posible aislar e identificar en la
fracción soluble en éter de petróleo seis componentes. A su vez en la fracción soluble en acetato de etilo se
aislaron e identificaron trece flavonoides al estado de aglucones o geninas, mientras que en la fracción soluble
con metanol se aislaron e identificaron diez flavonoides.; Geoffroea decorticans, commonly known as "chañar" or "chañarcillo" is a bush or tree
widely spread in Argentine and used in popular medicine as emollient, balsamic, antitusive and expectorant. Using
the tecnique of extraction by increasing the polarity of solventes was possible the isolation six compouds in
the petroleum light extract, thirteen flavonoids in the ethyl acetate extract and ten flavonoids in the methanol extract.
2004-01-01T00:00:00ZGeoffroea decorticans (Gill ex Hook et Arn) Burk. Leguminoseae (Fabaceae), de nombre común
"chañar" o "chañarcillo", es un árbol o arbusto de amplia distribución en la República Argentina y
se usa en la medicina popular por sus virtudes emolientes, balsámicas, antitusivas y expectorantes. Aplicando
la técnica de extracción con solventes de polaridad creciente fue posible aislar e identificar en la
fracción soluble en éter de petróleo seis componentes. A su vez en la fracción soluble en acetato de etilo se
aislaron e identificaron trece flavonoides al estado de aglucones o geninas, mientras que en la fracción soluble
con metanol se aislaron e identificaron diez flavonoides.
Geoffroea decorticans, commonly known as "chañar" or "chañarcillo" is a bush or tree
widely spread in Argentine and used in popular medicine as emollient, balsamic, antitusive and expectorant. Using
the tecnique of extraction by increasing the polarity of solventes was possible the isolation six compouds in
the petroleum light extract, thirteen flavonoids in the ethyl acetate extract and ten flavonoids in the methanol extract.Efecto hipoglucemiante del extracto acuoso de Phyllanthus sellowianus ("sarandí blanco") en ratones C57BL/KsNavarro, MónicaCoussio, Jorge DanielHnatyszyn, OksanaFerraro, Graciela Esterhttp://sedici.unlp.edu.ar:80/handle/10915/66952023-09-26T17:41:31Z2004-01-01T00:00:00ZArticulo
Hypoglycemic effect of an aqueous extract of phyllanthus sellowianus ("sarandí blanco") in C57BL/Ks mice
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Phyllanthus sellowianus Müller Arg. (Euphorbiaceae, n.v.: "sarandí blanco") es una especie vegetal ampliamente utilizada en medicina popular como hipoglucemiante y diurética. Se evaluó el efecto hipoglucemiante del extracto acuoso del "sarandí blanco" utilizando ratones C57BL/Ks db/m en distintas situaciones fisiológicas: a) en animales normales, b) con una sobrecarga de glucosa y c) con diabetes inducida mediante una serie de dosis bajas de estreptozotocina (STZ). En los animales normales se observó una leve reducción de la glucemia y en aquellos con sobrecarga de glucosa se potenció la capacidad de normalizar la glucemia. También se mantuvo la glucemia dentro de los rangos normales en ratones con diabetes inducida mediante un tratamiento con dosis bajas de STZ. Los resultados muestran claramente un efecto hipoglucemiante del extracto acuoso del "sarandí blanco" en ratones C57BL/Ks y proporcionan evidencias acerca de su potencial para la prevención y el tratamiento de la diabetes.; Phyllanthus sellowianus Müller Arg. (Euphorbiaceae, common name: "sarandí blanco") is a plant species widely used in popular medicine as hypoglycemic and diuretic. The hypoglycemic effect of the aqueous extract of P. sellowianus was evaluated using C57BL/Ks db/m mice in different physiological situations:
a) normal animals, b) animals with glucose overload, and c) animals with diabetes induced by repeated low doses of streptozotocin (STZ). In normal animals a slight reduction in the glucose levels was observed and in those with glucose overload the capacity to normalize the glucose levels was potentiated. In animals treated with low doses of STZ the blood glucose could also be mantained at normal levels. The results clearly show the hypoglycemic effect of the aqueous extract of P. sellowianus in C57BL/Ks mice and provide evidences for its potential use in prevention and treatment of diabetic disorders.
2004-01-01T00:00:00ZPhyllanthus sellowianus Müller Arg. (Euphorbiaceae, n.v.: "sarandí blanco") es una especie vegetal ampliamente utilizada en medicina popular como hipoglucemiante y diurética. Se evaluó el efecto hipoglucemiante del extracto acuoso del "sarandí blanco" utilizando ratones C57BL/Ks db/m en distintas situaciones fisiológicas: a) en animales normales, b) con una sobrecarga de glucosa y c) con diabetes inducida mediante una serie de dosis bajas de estreptozotocina (STZ). En los animales normales se observó una leve reducción de la glucemia y en aquellos con sobrecarga de glucosa se potenció la capacidad de normalizar la glucemia. También se mantuvo la glucemia dentro de los rangos normales en ratones con diabetes inducida mediante un tratamiento con dosis bajas de STZ. Los resultados muestran claramente un efecto hipoglucemiante del extracto acuoso del "sarandí blanco" en ratones C57BL/Ks y proporcionan evidencias acerca de su potencial para la prevención y el tratamiento de la diabetes.
Phyllanthus sellowianus Müller Arg. (Euphorbiaceae, common name: "sarandí blanco") is a plant species widely used in popular medicine as hypoglycemic and diuretic. The hypoglycemic effect of the aqueous extract of P. sellowianus was evaluated using C57BL/Ks db/m mice in different physiological situations:
a) normal animals, b) animals with glucose overload, and c) animals with diabetes induced by repeated low doses of streptozotocin (STZ). In normal animals a slight reduction in the glucose levels was observed and in those with glucose overload the capacity to normalize the glucose levels was potentiated. In animals treated with low doses of STZ the blood glucose could also be mantained at normal levels. The results clearly show the hypoglycemic effect of the aqueous extract of P. sellowianus in C57BL/Ks mice and provide evidences for its potential use in prevention and treatment of diabetic disorders.Estudio fitoquímico y farmacológico preliminar de plántulas de Alternanthera brasiliana cultivadas bajo diferentes cualidades espectrales de luzMacedo, Andrea F.Lage, Celso Luiz S.Esquibel, María AparecidaSouza, Márcia María deSilva, Karina L. daNiero, RivaldoCechinel Filho, Valdirhttp://sedici.unlp.edu.ar:80/handle/10915/66942014-08-14T15:26:48Z2004-01-01T00:00:00ZArticulo
Preliminary phytochemical and pharmacological studies on plantlets of Alternanthera brasiliana cultured under different spectral quality of lights
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Extractos metanólicos de plántulas de Alternanthera brasiliana,
cultivadas bajo diferentes cualidades espectrales de luz, fueron analizadas en dos modelos químicos de nocicepción
en ratones. Los resultados mostraron mayor biomasa en las plántulas cultivadas con los tratamientos de
luces azul y blanca. Extractos metanólicos (luces azules y blancas) administrados en concentraciones de 10
mg/kg del peso corporal, causaron inhibición de 51 y 62,5% para el test de contracciones y de 22 y 45,5% para el
test de capsaicina, respectivamente. El análisis fitoquímico indicó la ausencia de alcaloides o compuestos fenólicos,
pero sugiere la presencia de esteroides o terpenos.; Methanolic extracts from Alternanthera brasiliana plantlets cultured under different spectral
quality of lights were analyzed by two chemical nociception models in mice. The results showed a
highest biomass yield in plantlets developed under blue and white light treatments. The methanolic extracts
(blue and white lights) at 10 mg/kg body weight caused inhibition of 51 and 62.5% against writhing
test and 22 and 45.5% against capsaicin test, respectively. Phytochemical analysis indicated the absence of
alkaloids or phenolic compounds, but suggested the presence of steroids or terpenes.
2004-01-01T00:00:00ZExtractos metanólicos de plántulas de Alternanthera brasiliana,
cultivadas bajo diferentes cualidades espectrales de luz, fueron analizadas en dos modelos químicos de nocicepción
en ratones. Los resultados mostraron mayor biomasa en las plántulas cultivadas con los tratamientos de
luces azul y blanca. Extractos metanólicos (luces azules y blancas) administrados en concentraciones de 10
mg/kg del peso corporal, causaron inhibición de 51 y 62,5% para el test de contracciones y de 22 y 45,5% para el
test de capsaicina, respectivamente. El análisis fitoquímico indicó la ausencia de alcaloides o compuestos fenólicos,
pero sugiere la presencia de esteroides o terpenos.
Methanolic extracts from Alternanthera brasiliana plantlets cultured under different spectral
quality of lights were analyzed by two chemical nociception models in mice. The results showed a
highest biomass yield in plantlets developed under blue and white light treatments. The methanolic extracts
(blue and white lights) at 10 mg/kg body weight caused inhibition of 51 and 62.5% against writhing
test and 22 and 45.5% against capsaicin test, respectively. Phytochemical analysis indicated the absence of
alkaloids or phenolic compounds, but suggested the presence of steroids or terpenes.Efecto del extracto acuoso liofilizado de Boerhavia erecta L. sobre la anafilaxia pasiva cutánea, espasmo y tonicidad bronquial y la musculatura lisa intestinalNúñez Figueredo, YanierTillán Capó, JuanaVega Hurtado, YamiletGuerra, MartaRivero, ReinaldoGarrigó García, Eilynhttp://sedici.unlp.edu.ar:80/handle/10915/66932013-10-17T12:02:29Z2004-01-01T00:00:00ZArticulo
Effect of the liophilized aqueous extract of Boerhavia erecta L. on passive cutaneous anaphylaxis, spasm and bronchial tonitity
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Con el objetivo de demostrar las propiedades antialérgicas conferidas a Boerhavia erecta L.,
se estudió la posible influencia de la misma sobre los mediadores anafilácticos, espasmo y tonicidad bronquial
inducido por histamina y sobre la musculatura lisa intestinal en cobayos. Como resultado final de este
trabajo podemos concluir que el extracto acuoso liofilizado de Boerhavia erecta L. inhibe la anafilaxia
pasiva cutánea y el espasmo bronquial inducido por histamina. También pudimos apreciar que la dosis de
100 mg/Kg por vía intravenosa aumenta en un 46% la contracción provocada por histamina 15 µg/Kg y a
concentraciones superiores a 1 mg/mL provoca contracción de la musculatura lisa intestinal.; To study the anti-allergy properties conferred to Boerhavia erecta L. on
the anaphylactic mediators and H1 receptors at bronchial level, the tests of passive cutaneous anaphylaxis in rats
and bronchial spasm and tonicity on the intestinal flat musculature in guinea pigs were carried out. After our results
we can affirm that the extract watery of Boerhavia erecta L. inhibits the passive cutaneous anaphylaxis and
the bronchial spasm induced by histamina. We could also appreciate that the dose of 100 mg/Kg of Boerhavia
erecta L. after intravenous administration the contraction increases in 46% caused by histamina 15 µg/Kg and to
superior concentrations to 1 mg/mL causes contraction of the intestinal flat musculature.
2004-01-01T00:00:00ZCon el objetivo de demostrar las propiedades antialérgicas conferidas a Boerhavia erecta L.,
se estudió la posible influencia de la misma sobre los mediadores anafilácticos, espasmo y tonicidad bronquial
inducido por histamina y sobre la musculatura lisa intestinal en cobayos. Como resultado final de este
trabajo podemos concluir que el extracto acuoso liofilizado de Boerhavia erecta L. inhibe la anafilaxia
pasiva cutánea y el espasmo bronquial inducido por histamina. También pudimos apreciar que la dosis de
100 mg/Kg por vía intravenosa aumenta en un 46% la contracción provocada por histamina 15 µg/Kg y a
concentraciones superiores a 1 mg/mL provoca contracción de la musculatura lisa intestinal.
To study the anti-allergy properties conferred to Boerhavia erecta L. on
the anaphylactic mediators and H1 receptors at bronchial level, the tests of passive cutaneous anaphylaxis in rats
and bronchial spasm and tonicity on the intestinal flat musculature in guinea pigs were carried out. After our results
we can affirm that the extract watery of Boerhavia erecta L. inhibits the passive cutaneous anaphylaxis and
the bronchial spasm induced by histamina. We could also appreciate that the dose of 100 mg/Kg of Boerhavia
erecta L. after intravenous administration the contraction increases in 46% caused by histamina 15 µg/Kg and to
superior concentrations to 1 mg/mL causes contraction of the intestinal flat musculature.Análisis fitoquímico y actividad antiherpética in vitro de cuatro especies de ErythroxylumGonzález-Guevara, Johannes LuisGonzález Lavaut, José AntonioPino-Rodríguez, SuleyGarcía-Torres, MiladyCarballo-González, María TeresaEchemendía-Arana, Olga A.Molina Torres, JorgePrieto-González, Sylviahttp://sedici.unlp.edu.ar:80/handle/10915/66922018-02-09T18:31:07Z2004-01-01T00:00:00ZComunicacion
Phytochemical screening and in vitro antiherpetic activity of four Erythroxylum species
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Hojas de cuatro especies de Erythroxylum que crecen en Cuba fueron sometidas a análisis fitoquímico, identificándose alcaloides, triterpenoides/esteroides, lactonas/cumarinas, azúcares reductores, fenoles/taninos y flavonoides como sus principales metabolitos secundarios. Extractos hidroalcohólicos liofilizados de hojas de las cuatro especies de Erythroxylum estudiadas fueron ensayadas con respecto a su actividad sobre el virus del herpes simplex tipo 1. Los extractos hidroalcohólicos de dos de las especies (E. areolatum and E. confusum) inhibieron el crecimiento del virus.; Leaves from four Cuban Erythroxylum species were submitted to phytochemical screening. Alkaloids, triterpenoids/steroids, lactones/coumarins, reducing sugars, phenols/tannins and flavonoids were identified as principal secondary metabolites. Hydroalcoholic lyophilized leaf extracts from the four Erythroxylum species were assayed for activity against herpes simplex virus type 1. Hydroalcoholic extracts of two species (E. areolatum and E. confusum) inhibited the growth up of this virus.
2004-01-01T00:00:00ZHojas de cuatro especies de Erythroxylum que crecen en Cuba fueron sometidas a análisis fitoquímico, identificándose alcaloides, triterpenoides/esteroides, lactonas/cumarinas, azúcares reductores, fenoles/taninos y flavonoides como sus principales metabolitos secundarios. Extractos hidroalcohólicos liofilizados de hojas de las cuatro especies de Erythroxylum estudiadas fueron ensayadas con respecto a su actividad sobre el virus del herpes simplex tipo 1. Los extractos hidroalcohólicos de dos de las especies (E. areolatum and E. confusum) inhibieron el crecimiento del virus.
Leaves from four Cuban Erythroxylum species were submitted to phytochemical screening. Alkaloids, triterpenoids/steroids, lactones/coumarins, reducing sugars, phenols/tannins and flavonoids were identified as principal secondary metabolites. Hydroalcoholic lyophilized leaf extracts from the four Erythroxylum species were assayed for activity against herpes simplex virus type 1. Hydroalcoholic extracts of two species (E. areolatum and E. confusum) inhibited the growth up of this virus.Optimización en la separación de compuestos bioactivos de la Mandevilla illustris Vel. Woodson (Apocynaceae)Rodrigues, Clovis AntonioYunes, Rosendo AugustoChechinel Filho, ValdirLuciano Pacheco, RachelFeiten, KatyaneNiero, Rivaldohttp://sedici.unlp.edu.ar:80/handle/10915/66912013-10-17T12:02:29Z2004-01-01T00:00:00ZComunicacion
Optimization in the separation of bioactive compounds from Mandevilla illustris Vel. Woodson (Apocynaceae)
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Este trabajo presenta un estudio comparativo de la eficacia de diferentes adsorbentes cromatográficos
en el aislamiento del illustrol, un compuesto bioactivo con estructura de tipo nor-pregnano, a partir del
extracto obtenido con acetato de etilo de rizomas de Mandevilla illustris. La cromatografía en óxidos de alúmina
o magnesio permitió demostrar que la velocidad, rendimiento y el grado del pureza para el componente de interés
resultaron ser mayores que para un soporte tradicional como sílica gel 60.; This work presents a comparative study of the efficacy of different chromatographic supports
in the isolation of the illustrol, a bioactive nor-pregnane compound obtained from an ethyl acetate
extract of Mandevilla illustris rhizomes. When chromatographed over magnesium oxides, the speed, yield
and purity grade, for this compound, was higher than for a traditional support such as silica gel 60.
2004-01-01T00:00:00ZEste trabajo presenta un estudio comparativo de la eficacia de diferentes adsorbentes cromatográficos
en el aislamiento del illustrol, un compuesto bioactivo con estructura de tipo nor-pregnano, a partir del
extracto obtenido con acetato de etilo de rizomas de Mandevilla illustris. La cromatografía en óxidos de alúmina
o magnesio permitió demostrar que la velocidad, rendimiento y el grado del pureza para el componente de interés
resultaron ser mayores que para un soporte tradicional como sílica gel 60.
This work presents a comparative study of the efficacy of different chromatographic supports
in the isolation of the illustrol, a bioactive nor-pregnane compound obtained from an ethyl acetate
extract of Mandevilla illustris rhizomes. When chromatographed over magnesium oxides, the speed, yield
and purity grade, for this compound, was higher than for a traditional support such as silica gel 60.Influencia del pie de injerto en la composición del aceite esencial de mandarinaPedruzzi, LilianSantos, Ana Cristina dosAtti Serafini, LucianaMoyna, Patrickhttp://sedici.unlp.edu.ar:80/handle/10915/66902013-10-17T12:02:29Z2004-01-01T00:00:00ZArticulo
Influence of rootstock on essential oil composition of mandarins
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Se estudiaron los
aceites esenciales de cáscaras de frutos y hojas de mandarinas injertadas, cultivadas en Rio Grande do Sul (Brasil),
para establecer la influencia del pie, comparándolas con la misma variedad creciendo de semillas.; The peel and leaf essential oils obtained by hydrodistillation from grafted mandarins grown
in Rio Grande do Sul (Southern Brazil) were studied to establish the influence the roostock has, if any, on
grafted plants, comparing against the same plants grown from seedlings.
2004-01-01T00:00:00ZSe estudiaron los
aceites esenciales de cáscaras de frutos y hojas de mandarinas injertadas, cultivadas en Rio Grande do Sul (Brasil),
para establecer la influencia del pie, comparándolas con la misma variedad creciendo de semillas.
The peel and leaf essential oils obtained by hydrodistillation from grafted mandarins grown
in Rio Grande do Sul (Southern Brazil) were studied to establish the influence the roostock has, if any, on
grafted plants, comparing against the same plants grown from seedlings.Efecto antiinflamatorio del extracto acuoso liofilizado de Ocimum tenuiflorum L. en ratasBarzaga Fernández, PedroNúñez Figueredo, YanierCarrillo Domínguez, CarmenChávez Hernández, IsmaelGonzález Sanabria, María LidiaGonzález, RafaelEchevarría, Mayelinhttp://sedici.unlp.edu.ar:80/handle/10915/66892013-10-17T12:02:29Z2004-01-01T00:00:00ZArticulo
Anti-inflammatory effect of lyophilized aqueous extract of Ocinum tenuiflorum on rats
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Se estudió la actividad antiinflamatoria del extracto acuoso liofilizado de Ocimum tenuiflorum L. producido por el CIDEM en animales de experimentación. En ratas se evaluó el efecto de las dosis 250, 500 y 1000 mg/kg sobre la inflamación aguda provocada por carragenina, dextrán, histamina y serotonina; así como de 50, 150 y 450 mg/kg en el modelo de granuloma inducido por pellets de algodón. El extracto acuoso liofilizado mostró efecto inhibitorio sobre los edemas, excepto sobre el inducido por la serotonina. Las dosis de 150 y 450 mg/kg disminuyeron significativamente el peso del granuloma con ausencia de efectos sobre el timo y las glándulas suprarrenales. Estos resultados muestran que el extracto posee propiedades anti-inflamatorias interesantes para futuros estudios.; The anti-inflammatory activity of the lyophilized aqueous extract from Ocimum tenuiflorum L. produced by CIDEM was studied in experimental animals. The effect of 250, 500 and 1000 mg/kg was assesed in acute inflammation induced by carragenin, dextran, histamine and serotonine; as well as the effect of 50, 150 and 450 mg/kg in the granulome induced by cotton pellets. The lyophilized aqueous extract inhibited the increase of paw edema induced by carrageniin, dextran or histamine but it didn't over serotonine induced edema. The extract's doses 150 and 450 mg/kg diminished granulome's weight without affecting tymus's and adrenal's weight. Present results make the aqueous lyophilized extract from Ocimum tenuiflorum L. worthy of further investigations.
2004-01-01T00:00:00ZSe estudió la actividad antiinflamatoria del extracto acuoso liofilizado de Ocimum tenuiflorum L. producido por el CIDEM en animales de experimentación. En ratas se evaluó el efecto de las dosis 250, 500 y 1000 mg/kg sobre la inflamación aguda provocada por carragenina, dextrán, histamina y serotonina; así como de 50, 150 y 450 mg/kg en el modelo de granuloma inducido por pellets de algodón. El extracto acuoso liofilizado mostró efecto inhibitorio sobre los edemas, excepto sobre el inducido por la serotonina. Las dosis de 150 y 450 mg/kg disminuyeron significativamente el peso del granuloma con ausencia de efectos sobre el timo y las glándulas suprarrenales. Estos resultados muestran que el extracto posee propiedades anti-inflamatorias interesantes para futuros estudios.
The anti-inflammatory activity of the lyophilized aqueous extract from Ocimum tenuiflorum L. produced by CIDEM was studied in experimental animals. The effect of 250, 500 and 1000 mg/kg was assesed in acute inflammation induced by carragenin, dextran, histamine and serotonine; as well as the effect of 50, 150 and 450 mg/kg in the granulome induced by cotton pellets. The lyophilized aqueous extract inhibited the increase of paw edema induced by carrageniin, dextran or histamine but it didn't over serotonine induced edema. The extract's doses 150 and 450 mg/kg diminished granulome's weight without affecting tymus's and adrenal's weight. Present results make the aqueous lyophilized extract from Ocimum tenuiflorum L. worthy of further investigations.Medicamentos herbarios en el centro-oeste argentino, IV. "Marcelas" y "Vira-viras" en muestras comercialesPetenatti, Elisa M.Nievas, Carlos M.Petenatti, Marta E.Del Vitto, Luis A.http://sedici.unlp.edu.ar:80/handle/10915/66882013-10-17T12:02:29Z2004-01-01T00:00:00ZArticulo
Herbal remedies in Argentinian Central-western Region, IV. "Marcela" and "Vira-vira" in commercial samples
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Se han establecido los caracteres macro- y micromorfológicos diacríticos entre las dos únicas
entidades expendidas bajo los nombres vernáculos "marcela" y "vira-vira" en el centro-oeste de Argentina. Las principales diferencias estriban en la morfología y tipología de las inflorescencias y de su indumento. Gnaphalium gaudichaudianum DC. está caracterizada sobre todo por sus tricomas glandulíferos con pie 3-5-celular y cabezuela pequeña, 1-paucicelular, mientras que Achyrocline satureioides (Lam.) DC. presenta abundantes tricomas glandulíferos subsésiles, vesiculosos. Ambas corresponden a la Tribu Inuleae de la Familia Asteraceae. Se menciona también usos populares, composición química y otros datos relevantes porque constituyen medicamentos herbarios de amplio uso.; The diacritic macro- and micromorphological characters among two entities marketed under common names "marcela" y "vira-vira" as medicinal herb in central-western Argentinian region have been established. The main differences are related with the morphology and typology of their inflorescences and indument. Gnaphalium gaudichaudianum DC. (known as "marcela macho", too) is characterized mainly by their flagelliformis eglanduliferous trichomes 2-6- celled provided with a elonged apical cell and their glanduliferous ones, with 3-5-celled talk and a little 1-paucicelled head, while Achyrocline satureioides (Lam.) DC. (called "marcelita" or "marcela hembra", too) shows flagelliformis eglanduliferous trichomes and abundant glanduliferous, subsessilis, bladde-like trichomes. Both entities belongs to the Tribe Inuleae of the plant family Asteraceae. There are mentioned other features on their popular use, chemical composition, etc., that are relevant because there are widely used medicinal herbs.
2004-01-01T00:00:00ZSe han establecido los caracteres macro- y micromorfológicos diacríticos entre las dos únicas
entidades expendidas bajo los nombres vernáculos "marcela" y "vira-vira" en el centro-oeste de Argentina. Las principales diferencias estriban en la morfología y tipología de las inflorescencias y de su indumento. Gnaphalium gaudichaudianum DC. está caracterizada sobre todo por sus tricomas glandulíferos con pie 3-5-celular y cabezuela pequeña, 1-paucicelular, mientras que Achyrocline satureioides (Lam.) DC. presenta abundantes tricomas glandulíferos subsésiles, vesiculosos. Ambas corresponden a la Tribu Inuleae de la Familia Asteraceae. Se menciona también usos populares, composición química y otros datos relevantes porque constituyen medicamentos herbarios de amplio uso.
The diacritic macro- and micromorphological characters among two entities marketed under common names "marcela" y "vira-vira" as medicinal herb in central-western Argentinian region have been established. The main differences are related with the morphology and typology of their inflorescences and indument. Gnaphalium gaudichaudianum DC. (known as "marcela macho", too) is characterized mainly by their flagelliformis eglanduliferous trichomes 2-6- celled provided with a elonged apical cell and their glanduliferous ones, with 3-5-celled talk and a little 1-paucicelled head, while Achyrocline satureioides (Lam.) DC. (called "marcelita" or "marcela hembra", too) shows flagelliformis eglanduliferous trichomes and abundant glanduliferous, subsessilis, bladde-like trichomes. Both entities belongs to the Tribe Inuleae of the plant family Asteraceae. There are mentioned other features on their popular use, chemical composition, etc., that are relevant because there are widely used medicinal herbs.Morfoanatomia foliar e caulinar de Baccharis dracunculifolia DC., AsteraceaeManfron Budel, JaneDuarte, Márcia do Rociode Moraes Santos, Cid AimbiréFarago, Paulo V.http://sedici.unlp.edu.ar:80/handle/10915/66872013-10-17T12:02:29Z2004-01-01T00:00:00ZArticulo
Leaf and stem morpho-anatomy of Baccharis dracunculifolia DC., Asteraceae
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Baccharis dracunculifolia DC., pertencente ao grupo Spicata e à secção Discolores, é conhecida na medicina tradicional como "carqueja", "chilca", "vassourinha". É utilizada popularmente para combater distúrbios gástricos, inapetência, cansaço físico e afecções febris. O objetivo do trabalho foi realizar estudos morfoanatômicos da folha e do caule de B. dracunculifolia, contribuindo na diagnose desse fármaco vegetal e fornecendo subsídios taxonômicos ao grupo. O material botânico foi submetido às microtécnicas
fotônicas e eletrônicas de varredura usuais. As folhas são simples, inteiras, alternas, lanceoladas e medem 1-2 cm de comprimento e 3-4 mm de largura. Possuem epiderme uniestratificada com cutícula estriada, estômatos anomocíticos em ambas as faces, tricomas glandulares pluricelulares reunidos pela base em tufos, mesofilo isolateral e canais secretores associados aos feixes vasculares colaterais. O caule apresenta aspecto lenhoso e mede aproximadamente 2 m de altura e 5 mm de diâmetro. Revela formato circular em secção transversal, epiderme semelhante à foliar, canais secretores nas proximidades da bainha amilífera que envolve o sistema vascular e cristais de oxalato de cálcio na região perimedular.; Baccharis dracunculifolia DC. belongs to Spicata group and Discolores section, and is known in the traditional medicine as "carqueja", "chilca", "vassourinha". It is commonly employed for treating dyspepsia, anorexia, fatigue and mild fever. The aim of this work was to study the leaf and stem morpho-anatomy of B. dracunculifolia, in order to contribute for the drug identification and group taxonomy. Usual optical and scanning microtechniques were applied to the botanical material. The leaves are simple, entire, alternate, lanceolate and measure 1-2 cm long and 3-4 mm wide. They have uniseriate epidermis coated by striated cuticle, anomocytic stomata on both surfaces, pluricellular glandular trichomes united at the base, isobilateral mesophyll and secretory canals associated to collateral bundles. The stem has lignified aspect and approximately 2 m height and 5 mm of diameter. It shows circular transection, epidermis similar to the leaf one, secretory canals near the starch sheath which encircles the
vascular system, and calcium oxalate crystals in the outer layers of the pith.
2004-01-01T00:00:00ZBaccharis dracunculifolia DC., pertencente ao grupo Spicata e à secção Discolores, é conhecida na medicina tradicional como "carqueja", "chilca", "vassourinha". É utilizada popularmente para combater distúrbios gástricos, inapetência, cansaço físico e afecções febris. O objetivo do trabalho foi realizar estudos morfoanatômicos da folha e do caule de B. dracunculifolia, contribuindo na diagnose desse fármaco vegetal e fornecendo subsídios taxonômicos ao grupo. O material botânico foi submetido às microtécnicas
fotônicas e eletrônicas de varredura usuais. As folhas são simples, inteiras, alternas, lanceoladas e medem 1-2 cm de comprimento e 3-4 mm de largura. Possuem epiderme uniestratificada com cutícula estriada, estômatos anomocíticos em ambas as faces, tricomas glandulares pluricelulares reunidos pela base em tufos, mesofilo isolateral e canais secretores associados aos feixes vasculares colaterais. O caule apresenta aspecto lenhoso e mede aproximadamente 2 m de altura e 5 mm de diâmetro. Revela formato circular em secção transversal, epiderme semelhante à foliar, canais secretores nas proximidades da bainha amilífera que envolve o sistema vascular e cristais de oxalato de cálcio na região perimedular.
Baccharis dracunculifolia DC. belongs to Spicata group and Discolores section, and is known in the traditional medicine as "carqueja", "chilca", "vassourinha". It is commonly employed for treating dyspepsia, anorexia, fatigue and mild fever. The aim of this work was to study the leaf and stem morpho-anatomy of B. dracunculifolia, in order to contribute for the drug identification and group taxonomy. Usual optical and scanning microtechniques were applied to the botanical material. The leaves are simple, entire, alternate, lanceolate and measure 1-2 cm long and 3-4 mm wide. They have uniseriate epidermis coated by striated cuticle, anomocytic stomata on both surfaces, pluricellular glandular trichomes united at the base, isobilateral mesophyll and secretory canals associated to collateral bundles. The stem has lignified aspect and approximately 2 m height and 5 mm of diameter. It shows circular transection, epidermis similar to the leaf one, secretory canals near the starch sheath which encircles the
vascular system, and calcium oxalate crystals in the outer layers of the pith.Morfoanatomia de folhas de Maytenus rigida Mart. (Celastraceae); uma espécie utilizada como medicinal no Nordeste do BrasilSoares da Rocha, CristianoMagalhaes de Mendoça Pimentel, RejanePerrelli Randau, KarinaXavier, Haroudo Satirohttp://sedici.unlp.edu.ar:80/handle/10915/66862013-10-17T12:02:29Z2004-01-01T00:00:00ZArticulo
Morphoanatomy from leaves of Maytenus rigida Mart. (Celastraceae); a species used as medicinal in the Northeast of Brazil
Acta Farmacéutica Bonaerense; vol. 23, no. 4
A descrição morfoanatômica das folhas de Maytenus rigida Mart. é de extrema importância para
uma eficiente aplicabilidade desta planta à Farmacognosia. Os estudos da anatomia da folha de M. rigida
foram realizadas em cortes paradérmicos e transversais de material fresco à mão livre, corados com safranina
e azul de astra. As análises foram feitas em imagens digitais sob microscópio ótico pré-calibrado.
Os resultados obtidos neste estudo apontam caracteres anatômicos de valor diagnóstico, permitindo uma
identificação eficiente da espécie. A espécie apresentou folhas de consistência coriácea com cutícula fortemente
espessada nas paredes anticlinais, mesofilo isobilateral com três camadas de parênquima paliçádico
sob ambas as epidermes, estômatos paracíticos e anomocíticos em ambas as faces, abundância de drusas
no parênquima esponjoso, feixe vascular fechado, circundado por grupos de fibras gelatinosas e uma nervura
principal constituída por um único feixe vascular concêntrico fechado.; Leaf anatomical descriptions of Maytenus rigida Mart. is extremely important for
an efficient applicability of it to Pharmacognosy. The anatomical studies of M. rigida Mart. in transversal and paradermal
free-hand sections of fresh material, stained with safranin and astra blue, were made. The analysis was
done in digital images under a precalibrated light microscope. The results obtained showed valuable diagnostic
characters allowing an efficient identification of this specie. Coriaceous consistence with anticlinal strong thickness
cuticle, isobilateral mesophyll with tree layers of palisade parenchyma under both epidermis, paracitic and
anomocitic stomata on both epidermis, abundant druses in the spongy parenchyma, closed vascular bundle surrounded
of clustered gelatinous fibers and main bundle presenting a single close concentric vascular bundle.
2004-01-01T00:00:00ZA descrição morfoanatômica das folhas de Maytenus rigida Mart. é de extrema importância para
uma eficiente aplicabilidade desta planta à Farmacognosia. Os estudos da anatomia da folha de M. rigida
foram realizadas em cortes paradérmicos e transversais de material fresco à mão livre, corados com safranina
e azul de astra. As análises foram feitas em imagens digitais sob microscópio ótico pré-calibrado.
Os resultados obtidos neste estudo apontam caracteres anatômicos de valor diagnóstico, permitindo uma
identificação eficiente da espécie. A espécie apresentou folhas de consistência coriácea com cutícula fortemente
espessada nas paredes anticlinais, mesofilo isobilateral com três camadas de parênquima paliçádico
sob ambas as epidermes, estômatos paracíticos e anomocíticos em ambas as faces, abundância de drusas
no parênquima esponjoso, feixe vascular fechado, circundado por grupos de fibras gelatinosas e uma nervura
principal constituída por um único feixe vascular concêntrico fechado.
Leaf anatomical descriptions of Maytenus rigida Mart. is extremely important for
an efficient applicability of it to Pharmacognosy. The anatomical studies of M. rigida Mart. in transversal and paradermal
free-hand sections of fresh material, stained with safranin and astra blue, were made. The analysis was
done in digital images under a precalibrated light microscope. The results obtained showed valuable diagnostic
characters allowing an efficient identification of this specie. Coriaceous consistence with anticlinal strong thickness
cuticle, isobilateral mesophyll with tree layers of palisade parenchyma under both epidermis, paracitic and
anomocitic stomata on both epidermis, abundant druses in the spongy parenchyma, closed vascular bundle surrounded
of clustered gelatinous fibers and main bundle presenting a single close concentric vascular bundle.Evaluación del estrés oxidativo en pacientes pediátricos con SIDAGil del Valle, LizetteGonzález, IdaTarinas, AliciaÁlvarez, AlejandroMolina, RandelysTápanes, RolandoPérez, Jorgehttp://sedici.unlp.edu.ar:80/handle/10915/66852013-10-17T12:02:29Z2004-01-01T00:00:00ZArticulo
Evaluation of oxidative stress in AIDS pediatric patients
Acta Farmacéutica Bonaerense; vol. 23, no. 4
La infección por el virus de la inmunodeficiencia humana (VIH) continúa aumentando a nivel mundial. La progresión de la infección en niños es rápida. El proceso de estrés oxidativo asociado a la infección en adultos está bien documentado. La proteína viral Tat juega un papel reconocido en la generación intracelular de especies reactivas de oxígeno, evento este que repercute en el incremento del índice de apoptosis y en la disminución de los linfocitos T CD4<sup>+</sup>. El objetivo del presente trabajo fue evaluar un extenso grupo de marcadores del estado redox tales como: glutatión (GSH), malonildialdehido (MDA), potencial de peroxidación (PP), estado antioxidante total (TAS), glutatión peroxidasa (GPx), superóxido dismutasa (SOD), hidroperóxidos totales (TH) y % de fragmentación del ADN, en pacientes pediátricos comparados estadísticamente con individuos sanos. Muestras de sangre de 11 pacientes SIDA pediátricos y de 22 individuos sanos fueron utilizadas para realizar las mediciones de los marcadores del estado redox por técnicas espectrófotométricas. En el plasma de los pacientes SIDA pediátricos se detectó un nivel bajo de GSH, así como niveles altos de MDA y TH. Además se observó un mayor porcentaje de fragmentación del ADN en linfocitos, actividad enzimática de GPx disminuida y actividad mayor de SOD en eritrocitos en comparación con el grupo de individuos sanos. Se observaron diferencias significativas en cuanto a los índices del estado antioxidante global. Estos resultados corroboran las evidencias que el estado de estrés oxidativo se manifiesta durante la infección SIDA en pacientes pediátricos.; Infection by human immunodeficiency virus (HIV) continues to increase worldwide. The progression of the disease in children may be rapid. Oxidative stress is well documented in adult HIV/AIDS patients. Viral Tat protein plays a role in the intracellular generation of reactive oxygen species thus increasing apoptotic index, and depleting CD4<sup>+</sup>T lymphocytes. The aim of this study was to investigate an extensive array of redox status indices: glutathione (GSH), malondialdehyde (MDA), peroxidation potential, total antioxidant status, glutathione peroxidase (GPx), superoxide dismutase (SOD), Total hydroperoxide (TH) and DNA fragmentation in AIDS pediatrics patients compared to healthy subjects. Blood samples from 11 pediatric patients and 22 healthy subjects were tested by spectrophotometric techniques in order to measure oxidative stress indices. Both a reduction of GSH levels and an increase in MDA and TH levels were detected in the plasma of AIDS patients. These patients also showed an increase of DNA fragmentation in lymphocytes as well as a reduction of GPx and an increase in SOD activity in erythrocytes. Relatively to the control group, AIDS patients had differences in global indices of total antioxidant status. These results contribute to the evidences that substantial oxidative stress occurs during AIDS pediatric infection.
2004-01-01T00:00:00ZLa infección por el virus de la inmunodeficiencia humana (VIH) continúa aumentando a nivel mundial. La progresión de la infección en niños es rápida. El proceso de estrés oxidativo asociado a la infección en adultos está bien documentado. La proteína viral Tat juega un papel reconocido en la generación intracelular de especies reactivas de oxígeno, evento este que repercute en el incremento del índice de apoptosis y en la disminución de los linfocitos T CD4<sup>+</sup>. El objetivo del presente trabajo fue evaluar un extenso grupo de marcadores del estado redox tales como: glutatión (GSH), malonildialdehido (MDA), potencial de peroxidación (PP), estado antioxidante total (TAS), glutatión peroxidasa (GPx), superóxido dismutasa (SOD), hidroperóxidos totales (TH) y % de fragmentación del ADN, en pacientes pediátricos comparados estadísticamente con individuos sanos. Muestras de sangre de 11 pacientes SIDA pediátricos y de 22 individuos sanos fueron utilizadas para realizar las mediciones de los marcadores del estado redox por técnicas espectrófotométricas. En el plasma de los pacientes SIDA pediátricos se detectó un nivel bajo de GSH, así como niveles altos de MDA y TH. Además se observó un mayor porcentaje de fragmentación del ADN en linfocitos, actividad enzimática de GPx disminuida y actividad mayor de SOD en eritrocitos en comparación con el grupo de individuos sanos. Se observaron diferencias significativas en cuanto a los índices del estado antioxidante global. Estos resultados corroboran las evidencias que el estado de estrés oxidativo se manifiesta durante la infección SIDA en pacientes pediátricos.
Infection by human immunodeficiency virus (HIV) continues to increase worldwide. The progression of the disease in children may be rapid. Oxidative stress is well documented in adult HIV/AIDS patients. Viral Tat protein plays a role in the intracellular generation of reactive oxygen species thus increasing apoptotic index, and depleting CD4<sup>+</sup>T lymphocytes. The aim of this study was to investigate an extensive array of redox status indices: glutathione (GSH), malondialdehyde (MDA), peroxidation potential, total antioxidant status, glutathione peroxidase (GPx), superoxide dismutase (SOD), Total hydroperoxide (TH) and DNA fragmentation in AIDS pediatrics patients compared to healthy subjects. Blood samples from 11 pediatric patients and 22 healthy subjects were tested by spectrophotometric techniques in order to measure oxidative stress indices. Both a reduction of GSH levels and an increase in MDA and TH levels were detected in the plasma of AIDS patients. These patients also showed an increase of DNA fragmentation in lymphocytes as well as a reduction of GPx and an increase in SOD activity in erythrocytes. Relatively to the control group, AIDS patients had differences in global indices of total antioxidant status. These results contribute to the evidences that substantial oxidative stress occurs during AIDS pediatric infection.Análisis fitoquímico de Colliguaya integerrima (Hook.) Gill. et Hook. (Euphorbiaceae), una planta de la Patagonia argentinaPinto Vittorino, GracielaToledo, Ileana B.Córdoba, Osvaldo L.Flores, María L.Cabrera, José L.http://sedici.unlp.edu.ar:80/handle/10915/66842013-10-17T12:02:29Z2004-01-01T00:00:00ZArticulo
Acta Farmacéutica Bonaerense; vol. 23, no. 4
Colliguaya integerrima (Euphorbiaceae), "duraznillo patagónico", habita zonas áridas de Argentina. Se le han atribuido propiedades curativas y tóxicas. Se detectaron hidratos de carbono, proteínas y lípidos en las semillas, partes aéreas e inflorescencias, además de triterpenos en semillas; y flavonoides, saponinas y esteroides en partes aéreas e inflorescencias. Los principales monosacáridos detectados fueron galactosa en inflorescencias y partes aéreas, así como glucosa y fructosa en semillas. En las partes aéreas se identificaron delfinidina y pelargonidina. Los flavonoides de partes aéreas e inflorescencias demostraron una importante variabilidad estructural. El contenido de fenoles totales de las partes aéreas y de las inflorescencias fue en ambos casos de 12,9%, de los que 6,2% correspondieron a flavonoides en las partes aéreas, mientras que en las inflorescencias estos metabolitos representaron un 18,2%. El bioensayo de citotoxicidad de Artemia salina realizado al extracto metanólico de las partes aéreas mostró una DE50<150 µg/ml.; Colliguaya integerrima (Euphorbiaceae), "duraznillo patagónico", inhabits arid areas of Argentina. Healing and toxic properties have been attributed to it. Carbohydrates, proteins and lipids were detected in the seeds, air parts and inflorescences, besides triterpenes in seeds, and flavonoids, saponins and steroids in aerial parts and inflorescences. The main detected monosaccharides were galactose in inflorescences and aerial parts, and glucose and fructose in seeds. Delphinidin and pelargonidin were identified in aerial parts of this plant. Analysis of the flavonoids of aerial parts and inflorescences demonstrated an important structural variability. A 12,9% of total phenols was found in both aerial parts and inflorescences. However, the flavonoids content was found to be different, with a 6,2% for the aerial parts, and 18,2% for the inflorescences. Artemia salina citotoxicity's bioassay made on the methanolic extract of the aerial parts showed an ED50<150 µg/ml.
2004-01-01T00:00:00ZColliguaya integerrima (Euphorbiaceae), "duraznillo patagónico", habita zonas áridas de Argentina. Se le han atribuido propiedades curativas y tóxicas. Se detectaron hidratos de carbono, proteínas y lípidos en las semillas, partes aéreas e inflorescencias, además de triterpenos en semillas; y flavonoides, saponinas y esteroides en partes aéreas e inflorescencias. Los principales monosacáridos detectados fueron galactosa en inflorescencias y partes aéreas, así como glucosa y fructosa en semillas. En las partes aéreas se identificaron delfinidina y pelargonidina. Los flavonoides de partes aéreas e inflorescencias demostraron una importante variabilidad estructural. El contenido de fenoles totales de las partes aéreas y de las inflorescencias fue en ambos casos de 12,9%, de los que 6,2% correspondieron a flavonoides en las partes aéreas, mientras que en las inflorescencias estos metabolitos representaron un 18,2%. El bioensayo de citotoxicidad de Artemia salina realizado al extracto metanólico de las partes aéreas mostró una DE50<150 µg/ml.
Colliguaya integerrima (Euphorbiaceae), "duraznillo patagónico", inhabits arid areas of Argentina. Healing and toxic properties have been attributed to it. Carbohydrates, proteins and lipids were detected in the seeds, air parts and inflorescences, besides triterpenes in seeds, and flavonoids, saponins and steroids in aerial parts and inflorescences. The main detected monosaccharides were galactose in inflorescences and aerial parts, and glucose and fructose in seeds. Delphinidin and pelargonidin were identified in aerial parts of this plant. Analysis of the flavonoids of aerial parts and inflorescences demonstrated an important structural variability. A 12,9% of total phenols was found in both aerial parts and inflorescences. However, the flavonoids content was found to be different, with a 6,2% for the aerial parts, and 18,2% for the inflorescences. Artemia salina citotoxicity's bioassay made on the methanolic extract of the aerial parts showed an ED50<150 µg/ml.