http://sedici.unlp.edu.ar:80/handle/10915/219 2013-05-22T15:37:41Z 2013-05-22T15:37:41Z Erim, Gulcan Toker, Serdar Toker, Aysun http://sedici.unlp.edu.ar:80/handle/10915/7717 2012-05-03T01:50:38Z 2008-01-01T00:00:00Z

Contribucion a revista Latin American Journal of Pharmacy; vol. 27, no. 6 Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to bone fracture. Bone tissue undergoes constant remodeling. Under the physiologic conditions, bone formation and resorption are in a fair balance. After the third decade of life, bone resorption exceeds bone formation and leads to osteopenia and, in severe situations, osteoporosis. The result is fragile bones and an increased risk for fracture with even minimal trauma. Postmenopausal osteoporosis is thought to result from gonadal (ie, estrogen) deficiency. Estrogen deficiency have been reported to make decrease in 1-25 vitamin D, PTH levels and also calcium absorbsion and increased of some cytokines (ie. IL-1, TNF-alpha) may cause. it was noticed that Ursodeoxycholic acid (UDCA) may descrease these cytokines and increase fractional calcium absorbsion . Consequently, we hypotesize that UDCA might be useful Postmenopausal osteoporosis.

2008-01-01T00:00:00Z Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to bone fracture. Bone tissue undergoes constant remodeling. Under the physiologic conditions, bone formation and resorption are in a fair balance. After the third decade of life, bone resorption exceeds bone formation and leads to osteopenia and, in severe situations, osteoporosis. The result is fragile bones and an increased risk for fracture with even minimal trauma. Postmenopausal osteoporosis is thought to result from gonadal (ie, estrogen) deficiency. Estrogen deficiency have been reported to make decrease in 1-25 vitamin D, PTH levels and also calcium absorbsion and increased of some cytokines (ie. IL-1, TNF-alpha) may cause. it was noticed that Ursodeoxycholic acid (UDCA) may descrease these cytokines and increase fractional calcium absorbsion . Consequently, we hypotesize that UDCA might be useful Postmenopausal osteoporosis. Fernández Hernández, Nubia Pérez Davison, Gema Gregorio, Martínez Sánchez http://sedici.unlp.edu.ar:80/handle/10915/7716 2012-05-03T01:50:38Z 2008-01-01T00:00:00Z

Revision Vitíligo: a Review Latin American Journal of Pharmacy; vol. 27, no. 6 El vitíligo es uno de los desórdenes más frecuentes de hipopigmentación de la piel caracterizado por manchas de color blanco rosáceo, desprovistas de melanocitos identificables. El vitíligo resulta de una compleja interacción entre factores ambientales, genéticos e inmunológicos lo que contribuye en última instancia a la destrucción del melanocito. Su etiología no es bien conocida, se postulan varias teorías para explicar la pérdida de melanocitos epidérmicos. Con independencia de los resultados de las investigaciones más recientes, las estrategias de tratamientos persiguen el objetivo de restablecer la integridad funcional de los melanocitos y por tanto de la epidermis de pacientes con vitíligo. La terapia es combinada y depende del curso y localización de las lesiones.; Vitiligo is one of the most frequent disorders of the skin pigmentation characterized by white rosy stains, lacking identifiable melanocytes. The disease is a result of a complex interaction among environmental, genetic and immunologic factors that ultimately leads to melanocyte's destruction. The etiology is not very well-known; several theories are postulated to explain the loss of epidermal melanocytes. The treatment strategy is aimed at reestablishing melanocyte's functional integrity and thus, restoring the epidermis of the patient suffering from vitiligo. The proposed current therapy is combined and will depend on the course and localization of the lesions.

2008-01-01T00:00:00Z El vitíligo es uno de los desórdenes más frecuentes de hipopigmentación de la piel caracterizado por manchas de color blanco rosáceo, desprovistas de melanocitos identificables. El vitíligo resulta de una compleja interacción entre factores ambientales, genéticos e inmunológicos lo que contribuye en última instancia a la destrucción del melanocito. Su etiología no es bien conocida, se postulan varias teorías para explicar la pérdida de melanocitos epidérmicos. Con independencia de los resultados de las investigaciones más recientes, las estrategias de tratamientos persiguen el objetivo de restablecer la integridad funcional de los melanocitos y por tanto de la epidermis de pacientes con vitíligo. La terapia es combinada y depende del curso y localización de las lesiones. Vitiligo is one of the most frequent disorders of the skin pigmentation characterized by white rosy stains, lacking identifiable melanocytes. The disease is a result of a complex interaction among environmental, genetic and immunologic factors that ultimately leads to melanocyte's destruction. The etiology is not very well-known; several theories are postulated to explain the loss of epidermal melanocytes. The treatment strategy is aimed at reestablishing melanocyte's functional integrity and thus, restoring the epidermis of the patient suffering from vitiligo. The proposed current therapy is combined and will depend on the course and localization of the lesions. Bencke, Amanda Heineck, Isabela http://sedici.unlp.edu.ar:80/handle/10915/7715 2012-05-03T01:50:38Z 2008-01-01T00:00:00Z

Revision Efficacy and safety of tigecycline, the first antibioticof the glycylcyclines's class Latin American Journal of Pharmacy; vol. 27, no. 6 Nos últimos anos, observou-se uma importante escalada no surgimento de cepas resistentes aos agentes disponíveis. A classe das glicilciclinas foi desenvolvida com o objetivo de superar tais mecanismos de resistência, e a tigeciclina é o primeiro antibiótico desta classe aprovada para comercialização. Este trabalho avaliou a eficácia e segurança da tigeciclina através de revisão da literatura científica e constatou que, para as indicações aprovadas, o fármaco é comparável aos agentes classicamente utilizados. No entanto, vem sendo usado para várias outras indicações sem benefício comprovado.; In the last years, an important increase in the appearance of resistant strains to available agents has been observed. The glycylcyclines's class has been developed with the objective of overcame those resistance mechanisms, and tigecycline is the first antibiotic of this class approved for commercialization. This article evaluated the efficacy and safety of tigecycline by a review of the scientific literature and conclude that, for the approved indications, the drug is comparable with the classically used agents. However, has been used for several other indications without proven benefit.

2008-01-01T00:00:00Z Nos últimos anos, observou-se uma importante escalada no surgimento de cepas resistentes aos agentes disponíveis. A classe das glicilciclinas foi desenvolvida com o objetivo de superar tais mecanismos de resistência, e a tigeciclina é o primeiro antibiótico desta classe aprovada para comercialização. Este trabalho avaliou a eficácia e segurança da tigeciclina através de revisão da literatura científica e constatou que, para as indicações aprovadas, o fármaco é comparável aos agentes classicamente utilizados. No entanto, vem sendo usado para várias outras indicações sem benefício comprovado. In the last years, an important increase in the appearance of resistant strains to available agents has been observed. The glycylcyclines's class has been developed with the objective of overcame those resistance mechanisms, and tigecycline is the first antibiotic of this class approved for commercialization. This article evaluated the efficacy and safety of tigecycline by a review of the scientific literature and conclude that, for the approved indications, the drug is comparable with the classically used agents. However, has been used for several other indications without proven benefit. Pelegrini, Denise D. Tsuzuki, Joyce K. Amado, Ciomar A. B. Cortez, Diógenes A. G. Ferreira, Izabel C. P. http://sedici.unlp.edu.ar:80/handle/10915/7714 2012-05-03T01:50:38Z 2008-01-01T00:00:00Z

Revision Latin American Journal of Pharmacy; vol. 27, no. 6 Species of Sapindus (Sapindaceae) are widespread throughout the tropics (e.g., Brazil, China and India). The present report is based on available data and references on species of this genus. The main substances found in plants of the genus Sapindus are acetylated triterpenic saponin and acyclic sesquiterpene oligoglycosides. These plants have antimicrobial, spermicidal, antiulcer, hepatoprotective, molluscicidal, fungicidal and anti-inflammatory activity. In Brazil, the fruit of Sapindus saponaria L. is employed in folk medicine in the treatment of ulcers and external wounds.

2008-01-01T00:00:00Z Species of Sapindus (Sapindaceae) are widespread throughout the tropics (e.g., Brazil, China and India). The present report is based on available data and references on species of this genus. The main substances found in plants of the genus Sapindus are acetylated triterpenic saponin and acyclic sesquiterpene oligoglycosides. These plants have antimicrobial, spermicidal, antiulcer, hepatoprotective, molluscicidal, fungicidal and anti-inflammatory activity. In Brazil, the fruit of Sapindus saponaria L. is employed in folk medicine in the treatment of ulcers and external wounds. Akhter, Afsana Rahman, Mohammad S. Ahsan, Monira http://sedici.unlp.edu.ar:80/handle/10915/7713 2012-05-03T01:50:38Z 2008-01-01T00:00:00Z

Comunicacion Latin American Journal of Pharmacy; vol. 27, no. 6 The plant Jatropha pandurifolia (Euphorbiaceae) has ethnopharmacological reputation of being used as a healing agent in Bangladesh. In this study, preliminary screenings were conducted to look at the antimicrobial susceptibility and cytotoxicity of the plant extract. The n-hexane extract of the plant was subjected to screening for inhibition of microbial growth by the disc diffusion method and the average zone of inhibition was found 12-21 mm at a concentration of 500 μg/disc. The extract was also subjected to brine shrimp lethality bioassay for primary cytotoxicity evaluation and it revealed significant cytotoxicity with LC50 of 4.67 μg/ml. This is the first report of the antimicrobial activity and cytotoxicity of J. pandurifolia.

2008-01-01T00:00:00Z The plant Jatropha pandurifolia (Euphorbiaceae) has ethnopharmacological reputation of being used as a healing agent in Bangladesh. In this study, preliminary screenings were conducted to look at the antimicrobial susceptibility and cytotoxicity of the plant extract. The n-hexane extract of the plant was subjected to screening for inhibition of microbial growth by the disc diffusion method and the average zone of inhibition was found 12-21 mm at a concentration of 500 μg/disc. The extract was also subjected to brine shrimp lethality bioassay for primary cytotoxicity evaluation and it revealed significant cytotoxicity with LC50 of 4.67 μg/ml. This is the first report of the antimicrobial activity and cytotoxicity of J. pandurifolia. Lemos, Telma M. A. M. Aoyama, Hiroshi Cavagis, Alexandre D. M. http://sedici.unlp.edu.ar:80/handle/10915/7712 2012-05-03T01:50:39Z 2008-01-01T00:00:00Z

Comunicacion ytotoxicity of dehydrocrotonin (a nor-clerodane from Croton cajucara) on human lymphocytes Latin American Journal of Pharmacy; vol. 27, no. 6 Trans-Dehydrocrotonin, a 19-nor-clerodane, is the major norditerpene obtained from Croton cajucara, a Brazilian medicinal plant which presents important biological effects, such as antineoplastic and antiulcerogenic activities. In this work, we analyzed the effect of this sesquiterpene lactone on normal human lymphocytes. The cell viability was verified after treatment for 24 and 72 h with trans-dehydrocrotonin, in the presence and absence of phytohemagglutin (specific mitogen for this cell), through three endpoints to assess cytotoxicity in vitro: MTT reduction (mitochondrial function), protein quantification (cell number) and phosphatase activity (cell metabolism). When the cells were treated with dehydrocrotonin in the presence of mitogen, no toxic effect was observed. Nevertheless, in the absence of mitogen, the IC50 was 450 μM for MTT reduction and phosphatase activity. Moreover, in this condition, trans-dehydrocrotonin caused stimulation of protein content from 100 μM. Our results suggest that phytohemagglutin protects human lymphocytes against the trans-dehydrocrotonin toxic effect.

2008-01-01T00:00:00Z Trans-Dehydrocrotonin, a 19-nor-clerodane, is the major norditerpene obtained from Croton cajucara, a Brazilian medicinal plant which presents important biological effects, such as antineoplastic and antiulcerogenic activities. In this work, we analyzed the effect of this sesquiterpene lactone on normal human lymphocytes. The cell viability was verified after treatment for 24 and 72 h with trans-dehydrocrotonin, in the presence and absence of phytohemagglutin (specific mitogen for this cell), through three endpoints to assess cytotoxicity in vitro: MTT reduction (mitochondrial function), protein quantification (cell number) and phosphatase activity (cell metabolism). When the cells were treated with dehydrocrotonin in the presence of mitogen, no toxic effect was observed. Nevertheless, in the absence of mitogen, the IC50 was 450 μM for MTT reduction and phosphatase activity. Moreover, in this condition, trans-dehydrocrotonin caused stimulation of protein content from 100 μM. Our results suggest that phytohemagglutin protects human lymphocytes against the trans-dehydrocrotonin toxic effect. Sá Barreto, Lívia C.L. Cunha Filho, Marcílio Souza, Ivone A. Fraga, María do Carmo C. A. Xavier, Haroudo Satiro http://sedici.unlp.edu.ar:80/handle/10915/7711 2012-05-03T01:50:39Z 2008-01-01T00:00:00Z

Articulo Preliminary assay of biological activity and acute toxicity of Vitex gardneriana Schauer (Verbenaceae) Latin American Journal of Pharmacy; vol. 27, no. 6 O presente trabalho investigou pela primeira vez a atividade biológica e a toxicidade aguda de Vitex gardneriana Schauer, planta de utilização popular encontrada no sertão nordestino do Brasil. A toxicidade aguda, determinada por via oral e intraperitoneal, e diferentes atividades farmacológicas (antimicrobiana, anti-inflamatória, analgésica e hipnótica) foram pesquisadas utilizando soluções aquosas dos extratos brutos das cascas do caule e das folhas. Não se detectou sinais de toxicidade em nenhuma das doses testadas (250-2000 mg/kg). Foram encontrados relevantes efeitos farmacológicos nos extratos das folhas, que apresentaram ações anti-edematogênicas, antinociceptivas e sedantes. Os resultados encontrados corroboram a utilização popular de V. gardneriana e sugerem um excelente potencial terapêutico.; The biological activity and the acute toxicity of Vitex gardneriana Schauer, a medicinal plant with popular use, were investigated. Acute toxicity after oral and intraperitoneal administration, antimicrobial, anti-inflammatory, analgesic and hypnotic tests were carried out using leaves and stem bark aqueous extracts. No signs of toxicity were found in the dosage range tested (250-2000 mg/kg). Important pharmacological effects were found for leaves extract, which presented anti-edematogenic, anti-nociceptive and sedative actions. These results corroborate the popular use of V. gardneriana and point out a promising therapeutic potential.

2008-01-01T00:00:00Z O presente trabalho investigou pela primeira vez a atividade biológica e a toxicidade aguda de Vitex gardneriana Schauer, planta de utilização popular encontrada no sertão nordestino do Brasil. A toxicidade aguda, determinada por via oral e intraperitoneal, e diferentes atividades farmacológicas (antimicrobiana, anti-inflamatória, analgésica e hipnótica) foram pesquisadas utilizando soluções aquosas dos extratos brutos das cascas do caule e das folhas. Não se detectou sinais de toxicidade em nenhuma das doses testadas (250-2000 mg/kg). Foram encontrados relevantes efeitos farmacológicos nos extratos das folhas, que apresentaram ações anti-edematogênicas, antinociceptivas e sedantes. Os resultados encontrados corroboram a utilização popular de V. gardneriana e sugerem um excelente potencial terapêutico. The biological activity and the acute toxicity of Vitex gardneriana Schauer, a medicinal plant with popular use, were investigated. Acute toxicity after oral and intraperitoneal administration, antimicrobial, anti-inflammatory, analgesic and hypnotic tests were carried out using leaves and stem bark aqueous extracts. No signs of toxicity were found in the dosage range tested (250-2000 mg/kg). Important pharmacological effects were found for leaves extract, which presented anti-edematogenic, anti-nociceptive and sedative actions. These results corroborate the popular use of V. gardneriana and point out a promising therapeutic potential. Oliveira, Ralph Santos http://sedici.unlp.edu.ar:80/handle/10915/7710 2012-05-03T01:50:39Z 2008-01-01T00:00:00Z

Comunicacion Radiopharmaceutical regulation: European Union, United States and Brazil Latin American Journal of Pharmacy; vol. 27, no. 6 Após uma breve introdução este artigo relata e a experiência da União Européia, dos Estados Unidos e do Brasil, na regulamentação de radiofármacos, elencando os principais atos normativos e identificando as principais ações tomadas até o presente momento.; After a brief introduction, this article relate the experience of European Union, United States and Brazil in the radiopharmaceuticals regulation, pointing the laws and indentifying the actions that have been taken until the preset time.

2008-01-01T00:00:00Z Após uma breve introdução este artigo relata e a experiência da União Européia, dos Estados Unidos e do Brasil, na regulamentação de radiofármacos, elencando os principais atos normativos e identificando as principais ações tomadas até o presente momento. After a brief introduction, this article relate the experience of European Union, United States and Brazil in the radiopharmaceuticals regulation, pointing the laws and indentifying the actions that have been taken until the preset time. Mascotti, María L. Enriz, Ricardo Daniel Giannini, Fernando Angel http://sedici.unlp.edu.ar:80/handle/10915/7709 2012-05-03T01:50:39Z 2008-01-01T00:00:00Z

Comunicacion Latin American Journal of Pharmacy; vol. 27, no. 6 Commercial antifungal drugs possess important side effect; being toxicity the main limitation of such compounds. We report here a study of acute toxicity of four well-known commercial antifungal drugs; two of them used in human medicine (griseofulvine and miconazole) and the other two used against phytopatogens fungi (carbendazin and benomil). Toxic effects of these compounds were evaluated using an acute toxicity test on fish of the specie Poecilia reticulata.

2008-01-01T00:00:00Z Commercial antifungal drugs possess important side effect; being toxicity the main limitation of such compounds. We report here a study of acute toxicity of four well-known commercial antifungal drugs; two of them used in human medicine (griseofulvine and miconazole) and the other two used against phytopatogens fungi (carbendazin and benomil). Toxic effects of these compounds were evaluated using an acute toxicity test on fish of the specie Poecilia reticulata. Regasini, Luis O. Cotinguiba, Fernando Siqueira, Janaina R. Bolzani, Vanderlan S. Silva, Dulce Furlan, Maysa Katto, Masuo J. http://sedici.unlp.edu.ar:80/handle/10915/7708 2012-05-03T01:50:39Z 2008-01-01T00:00:00Z

Comunicacion Latin American Journal of Pharmacy; vol. 27, no. 6 In the scope of our ongoing researchers on antioxidant compounds, twenty four extracts and fractions obtained from Piper arboreum Aublet and Piper tuberculatum Jacq. (Piperaceae) were screened for radical scavenging capacity (RSC) by using DPPH colorimetric assay. The strongest activity was found in ethyl acetate fractions from the leaves of P. arboreum (IC₅₀ = 5.70 μg/mL) and P. tuberculatum (IC₅₀ = 8.40 μg/mL). Hydromethanol fractions of the leaves of P. tuberculatum and P. arboreum showed moderate RSC, with values of IC50 (μg/mL) of 11.9 and 19.2, respectively. Additionally, a brief phytochemical study of the ethyl acetate fraction of P. arboreum leaves affording quercetin (1) and quercitrin (2), two flavonols with antioxidant activity previously described in the literature.

2008-01-01T00:00:00Z In the scope of our ongoing researchers on antioxidant compounds, twenty four extracts and fractions obtained from Piper arboreum Aublet and Piper tuberculatum Jacq. (Piperaceae) were screened for radical scavenging capacity (RSC) by using DPPH colorimetric assay. The strongest activity was found in ethyl acetate fractions from the leaves of P. arboreum (IC₅₀ = 5.70 μg/mL) and P. tuberculatum (IC₅₀ = 8.40 μg/mL). Hydromethanol fractions of the leaves of P. tuberculatum and P. arboreum showed moderate RSC, with values of IC50 (μg/mL) of 11.9 and 19.2, respectively. Additionally, a brief phytochemical study of the ethyl acetate fraction of P. arboreum leaves affording quercetin (1) and quercitrin (2), two flavonols with antioxidant activity previously described in the literature. Avancini, César Wiest, José M. Haas, Juliana Schulte Poser, Gilsane Lino von Dall'Agnol, Rodrigo http://sedici.unlp.edu.ar:80/handle/10915/7707 2012-05-03T01:50:39Z 2008-01-01T00:00:00Z

Articulo Latin American Journal of Pharmacy; vol. 27, no. 6 Based on informal interview, ethnoveterinary information about plants used in the prevention and control of bovine mastitis in Southern Brazil were obtained. Alternanthera brasiliana (L.) Ktze. ("penicilina"), Foeniculum vulgare Mill ("funcho"), Aloe arborescens Mill. ("babosa"), Achillea millefolium L. ("mil-em-rama"), Baccharis trimera (Less.) DC. ("carqueja"), Solidago chilensis Meyer ("lanceta"), Symphythum officinale L. ("confrei"), Sambucus nigra L. ("sabugueiro"), Chenopodium ambrosioides Linn. ("erva Santa Maria"), Mentha sp. ("hortelã"), Ocimum basilicum L. ("alfavaca"), Parapiptadenia rigida (Benth.) Brean ("angico-vermelho"), Allium sativum L. (alho), Cuphea carthagenensis (Jacq.) Macbr. ("sete-sangrias"), Sida rhombifolia L. ("guanxuma"), Phytolacca dioica L. ("umbu") and Solanum mauritianum Scop ("fumeiro-brabo") were cited as helpful. In order to validate the traditional practice, the decoctions obtained with the plants were analyzed for the in vitro antimicrobial activity against Staphylococcus aureus and Salmonella choleraesuis by the agar dilution method. Alternanthera brasiliana, Achillea millefolium, Baccharis trimera and Solidago chilensis extracts where active against S. aureus while Symphythum officinale, Sambucus nigra, Mentha sp., Ocimum basilicum, Parapiptadenia rigida and Cuphea carthagenensis extracts were active against both microorganisms. For all the cited species, scientific data were reviewed aiming to establish a correlation between popular use and biological properties. The data found in literature for several of these plants could justify the use in the bovine mastitis treatment for antimicrobial, anti-inflammatory and wound healing activities.

2008-01-01T00:00:00Z Based on informal interview, ethnoveterinary information about plants used in the prevention and control of bovine mastitis in Southern Brazil were obtained. Alternanthera brasiliana (L.) Ktze. ("penicilina"), Foeniculum vulgare Mill ("funcho"), Aloe arborescens Mill. ("babosa"), Achillea millefolium L. ("mil-em-rama"), Baccharis trimera (Less.) DC. ("carqueja"), Solidago chilensis Meyer ("lanceta"), Symphythum officinale L. ("confrei"), Sambucus nigra L. ("sabugueiro"), Chenopodium ambrosioides Linn. ("erva Santa Maria"), Mentha sp. ("hortelã"), Ocimum basilicum L. ("alfavaca"), Parapiptadenia rigida (Benth.) Brean ("angico-vermelho"), Allium sativum L. (alho), Cuphea carthagenensis (Jacq.) Macbr. ("sete-sangrias"), Sida rhombifolia L. ("guanxuma"), Phytolacca dioica L. ("umbu") and Solanum mauritianum Scop ("fumeiro-brabo") were cited as helpful. In order to validate the traditional practice, the decoctions obtained with the plants were analyzed for the in vitro antimicrobial activity against Staphylococcus aureus and Salmonella choleraesuis by the agar dilution method. Alternanthera brasiliana, Achillea millefolium, Baccharis trimera and Solidago chilensis extracts where active against S. aureus while Symphythum officinale, Sambucus nigra, Mentha sp., Ocimum basilicum, Parapiptadenia rigida and Cuphea carthagenensis extracts were active against both microorganisms. For all the cited species, scientific data were reviewed aiming to establish a correlation between popular use and biological properties. The data found in literature for several of these plants could justify the use in the bovine mastitis treatment for antimicrobial, anti-inflammatory and wound healing activities. Volonté, María Guillermina Ruiz, María Esperanza Rubini, Agustina Pozzo, Ricardo http://sedici.unlp.edu.ar:80/handle/10915/7706 2012-05-03T01:50:39Z 2008-01-01T00:00:00Z

Articulo Pharmaceutical equivalence of Metronidazole 500 mg Latin American Journal of Pharmacy; vol. 27, no. 6 Metronidazol (MTZ) es un antibacteriano, antiprotozoario y antihelmíntico ampliamente utilizado en infecciones de distinto origen. La finalidad de este trabajo fue determinar la Equivalencia Farmacéutica (EF) de los distintos productos, formulaciones sólidas de administración oral conteniendo 500 mg de MTZ, disponibles en el mercado farmacéutico argentino, en el momento del presente estudio. Se analizaron comprimidos de catorce marcas, todas ellas dentro de su período de validez de uso. Los ensayos realizados fueron: evaluación de rótulos y prospectos, descripción de los comprimidos, identidad y contenido de MTZ, uniformidad de unidades de dosificación, ensayo de disolución y perfiles de disolución. Se concluyó que no todas las especialidades medicinales conteniendo MTZ 500 mg, en su forma farmacéutica comprimidos, a la fecha del presente estudio, son equivalentes farmacéuticos.; Metronidazole (MTZ) is widely used as antiprotozoal, antiamebic and antibacterial drug to treat a broad range of infections caused by anaerobic protists and bacteria. The aim of this study was to compare the fourteen products, MTZ tablets 500 mg, which were available in the argentine pharmaceutical market, looking to the pharmaceutical equivalence between them. The following tests were made: evaluation of packaging specifications, description of tablets, identification and quantification, uniformity of dosage units, dissolution test and dissolution profiles. We conclude that there is not pharmaceutical equivalence between all the studied products at the moment of the present study.

2008-01-01T00:00:00Z Metronidazol (MTZ) es un antibacteriano, antiprotozoario y antihelmíntico ampliamente utilizado en infecciones de distinto origen. La finalidad de este trabajo fue determinar la Equivalencia Farmacéutica (EF) de los distintos productos, formulaciones sólidas de administración oral conteniendo 500 mg de MTZ, disponibles en el mercado farmacéutico argentino, en el momento del presente estudio. Se analizaron comprimidos de catorce marcas, todas ellas dentro de su período de validez de uso. Los ensayos realizados fueron: evaluación de rótulos y prospectos, descripción de los comprimidos, identidad y contenido de MTZ, uniformidad de unidades de dosificación, ensayo de disolución y perfiles de disolución. Se concluyó que no todas las especialidades medicinales conteniendo MTZ 500 mg, en su forma farmacéutica comprimidos, a la fecha del presente estudio, son equivalentes farmacéuticos. Metronidazole (MTZ) is widely used as antiprotozoal, antiamebic and antibacterial drug to treat a broad range of infections caused by anaerobic protists and bacteria. The aim of this study was to compare the fourteen products, MTZ tablets 500 mg, which were available in the argentine pharmaceutical market, looking to the pharmaceutical equivalence between them. The following tests were made: evaluation of packaging specifications, description of tablets, identification and quantification, uniformity of dosage units, dissolution test and dissolution profiles. We conclude that there is not pharmaceutical equivalence between all the studied products at the moment of the present study. Valdes, Rodolfo Medina, Yenisley Fernández, Eutimio G. Geada, Déborah Ferro, Williams Álvarez, Tatiana Padilla, Sigifredo Guevara, Yaryse Tamayo, Andrés Gomez, Leonardo Montero, José Figueroa, Alejandro Calas, Gisela García A., Cristina http://sedici.unlp.edu.ar:80/handle/10915/7705 2012-05-03T01:50:39Z 2008-01-01T00:00:00Z

Articulo Latin American Journal of Pharmacy; vol. 27, no. 6 Immunoaffinity chromatography (IAC) has a wide application in protein purification. The aim of the study was to investigate the influence of five operational factors on an IAC procedure to purify a yeast derived-Hepatitis B surface antigen (rHBsAg) for pharmaceutical use. The immunosorbent adsorption capacity of the rHBsAg is affected at 4 °C. The applied antigen concentration, 100-1000 μg mL^-1, does not have influence on this IAC efficiency. The residence time, applied antigen amount and column geometry have a significant influence on the adsorption and elution capacity, and recovery of the rHBsAg. There is a marked retention of the rHBsAg into the matrix, which is reduced at residence times higher than 2 h. A high height/diameter ratio of the column, 3.75, reduces the antigen adsorption to the matrix but increases the recovery and the productivity for this high molecular weight (multiple chemical forms) antigen and a high affinity constant ligand. The solution of the rHBsAg retention into the matrix could increase by 30% the active pharmaceutical ingredient purification and the Hepatitis B vaccine production.

2008-01-01T00:00:00Z Immunoaffinity chromatography (IAC) has a wide application in protein purification. The aim of the study was to investigate the influence of five operational factors on an IAC procedure to purify a yeast derived-Hepatitis B surface antigen (rHBsAg) for pharmaceutical use. The immunosorbent adsorption capacity of the rHBsAg is affected at 4 °C. The applied antigen concentration, 100-1000 μg mL^-1, does not have influence on this IAC efficiency. The residence time, applied antigen amount and column geometry have a significant influence on the adsorption and elution capacity, and recovery of the rHBsAg. There is a marked retention of the rHBsAg into the matrix, which is reduced at residence times higher than 2 h. A high height/diameter ratio of the column, 3.75, reduces the antigen adsorption to the matrix but increases the recovery and the productivity for this high molecular weight (multiple chemical forms) antigen and a high affinity constant ligand. The solution of the rHBsAg retention into the matrix could increase by 30% the active pharmaceutical ingredient purification and the Hepatitis B vaccine production. Schwanz, Melissa Nunes, Eliana Konrath, Eduardo L. Vendruscolo, Giovana S. Silva, Márcia Vignoli da Henriques, Amélia T. Mentz, Lilian Auler http://sedici.unlp.edu.ar:80/handle/10915/7704 2012-05-03T01:50:39Z 2008-01-01T00:00:00Z

Articulo Pharmacobotanical characterization of Peumus boldus Molina (Monimiaceae) and Evaluation of the pharmacological activities of alkaloid boldine Latin American Journal of Pharmacy; vol. 27, no. 6 Peumus boldus Molina (Monimiaceae) is a medicinal plant known in Brazil as "boldo" or "boldo-do-chile", and its leaves are popularly used in digestive and hepatic diseases. A pharmacobotanical study was carried out, macro and microscopically features were illustrated and described, in an attempt to complement the fourth edition of the Brazilian Pharmacopoea monograph. Some special characters can be used to identify this drug: revolute margined leaves, typical color and texture, covering stellate trichomes, secretory cells, hypoestomatic mesophyll, anomocytic stomata, and crystals. Boldine, the major alkaloid found in this species, exhibited potent antioxidant activity and an unprecedented anticholinesterasic effect, both demonstrated through autobiographic assays.; Peumus boldus Molina (família Monimiaceae) é conhecido no Brasil como "boldo" ou "boldodo- chile", sendo suas folhas empregadas como remédio em afecções do sistema digestivo e hepatobiliar. Foi realizado um estudo botânico macro e microscópico das folhas e do pó, ilustrando e complementando a monografia da Farmacopéia Brasileira, quarta edição. Características como bordo revoluto, tricomas estrelados, células secretoras visíveis, coloração e textura, são macroscopicamente úteis; lâmina hipoestomática, estômatos anomocíticos e cristais, microscopicamente identificam a espécie. Ensaios autobiográficos verificaram um potente efeito antioxidante e uma inédita atividade anticolinesterásica para a boldina, alcalóide majoritário desta espécie.

2008-01-01T00:00:00Z Peumus boldus Molina (Monimiaceae) is a medicinal plant known in Brazil as "boldo" or "boldo-do-chile", and its leaves are popularly used in digestive and hepatic diseases. A pharmacobotanical study was carried out, macro and microscopically features were illustrated and described, in an attempt to complement the fourth edition of the Brazilian Pharmacopoea monograph. Some special characters can be used to identify this drug: revolute margined leaves, typical color and texture, covering stellate trichomes, secretory cells, hypoestomatic mesophyll, anomocytic stomata, and crystals. Boldine, the major alkaloid found in this species, exhibited potent antioxidant activity and an unprecedented anticholinesterasic effect, both demonstrated through autobiographic assays. Peumus boldus Molina (família Monimiaceae) é conhecido no Brasil como "boldo" ou "boldodo- chile", sendo suas folhas empregadas como remédio em afecções do sistema digestivo e hepatobiliar. Foi realizado um estudo botânico macro e microscópico das folhas e do pó, ilustrando e complementando a monografia da Farmacopéia Brasileira, quarta edição. Características como bordo revoluto, tricomas estrelados, células secretoras visíveis, coloração e textura, são macroscopicamente úteis; lâmina hipoestomática, estômatos anomocíticos e cristais, microscopicamente identificam a espécie. Ensaios autobiográficos verificaram um potente efeito antioxidante e uma inédita atividade anticolinesterásica para a boldina, alcalóide majoritário desta espécie. Dutra, Rafael C. Trevizani, Raphael Pittella, Federico Barbosa, Nádia R. http://sedici.unlp.edu.ar:80/handle/10915/7703 2012-05-03T01:50:39Z 2008-01-01T00:00:00Z

Articulo Latin American Journal of Pharmacy; vol. 27, no. 6 In the present study the antinociceptive property of Pterodon emarginatus Vog. (Leguminosae) seeds essential oil (EO) and fractions was investigated. The writhing test induced by acetic acid, paw licking induced by formalin and hot plate tests were performed in Swiss albino mice (n = 8-10/group), by oral route at doses of 100, 300 and 500 mg/kg. The EO, hexanic (HF) and buthanolic (BF) fractions reduced (p < 0.01) the abdominal contortions (100 mg/kg = 22.75 ± 4.03, 14.38 ± 3.41 and 24.6 ± 4.48; 300 mg/kg = 14.00 ± 5.81, 12.13 ± 3.19, and 25.88 ± 2.78; 500 mg/kg = 11.13 ± 3.59, 9.00 ± 2.09 and 17.75 ± 4.82), respectively when compared with control group. The EO and methanolic fraction (MF) reduced the paw licking in both phases (p<0.05): 1st phase (100 mg/kg = 31.63 ± 14.17 and 60.50 ± 11.61; 300 mg/kg = 28.38 ± 5.72 and 47.75 ± 6.13; 500 mg/kg = 28,25 ± 4.19 and 44.63 ± 6.33) and 2nd phase (100 mg/kg = 53.50 ± 11.96 and 24.13 ± 12.38; 300 mg/kg = 43.75 ± 11.91 and 35.13 ± 12.35; 500 mg/kg = 9.00 ± 4.41 and 23.50 ± 10.18), respectively. Only HF showed effect on the reaction time at hot plate were significant (p<0.05) after 60 min of treatment. These results suggest that Pterodon emarginatus could constitute a source of active substances with antinociceptive effect.

2008-01-01T00:00:00Z In the present study the antinociceptive property of Pterodon emarginatus Vog. (Leguminosae) seeds essential oil (EO) and fractions was investigated. The writhing test induced by acetic acid, paw licking induced by formalin and hot plate tests were performed in Swiss albino mice (n = 8-10/group), by oral route at doses of 100, 300 and 500 mg/kg. The EO, hexanic (HF) and buthanolic (BF) fractions reduced (p < 0.01) the abdominal contortions (100 mg/kg = 22.75 ± 4.03, 14.38 ± 3.41 and 24.6 ± 4.48; 300 mg/kg = 14.00 ± 5.81, 12.13 ± 3.19, and 25.88 ± 2.78; 500 mg/kg = 11.13 ± 3.59, 9.00 ± 2.09 and 17.75 ± 4.82), respectively when compared with control group. The EO and methanolic fraction (MF) reduced the paw licking in both phases (p<0.05): 1st phase (100 mg/kg = 31.63 ± 14.17 and 60.50 ± 11.61; 300 mg/kg = 28.38 ± 5.72 and 47.75 ± 6.13; 500 mg/kg = 28,25 ± 4.19 and 44.63 ± 6.33) and 2nd phase (100 mg/kg = 53.50 ± 11.96 and 24.13 ± 12.38; 300 mg/kg = 43.75 ± 11.91 and 35.13 ± 12.35; 500 mg/kg = 9.00 ± 4.41 and 23.50 ± 10.18), respectively. Only HF showed effect on the reaction time at hot plate were significant (p<0.05) after 60 min of treatment. These results suggest that Pterodon emarginatus could constitute a source of active substances with antinociceptive effect. Gatti, Walter Omar Jeandupeux, René Cafferata, Lázaro F. R. http://sedici.unlp.edu.ar:80/handle/10915/7702 2012-05-03T01:50:39Z 2008-01-01T00:00:00Z

Articulo Matter transference towards the solution during the extraction of plant bioactive products and its degradation in solvent mixtures Latin American Journal of Pharmacy; vol. 27, no. 6 Se ha realizado una evaluación analítica cuantitativa de la extracción de la droga antimalárica natural artemisinina, presente en plantas silvestres de Artemisia annua L., utilizando mezclas de etanol 70% (v/v) - agua. El objetivo ha sido encontrar una justificación de la reducida recuperación de esa droga en los procesos de su aislamiento ya indicados en la literatura y que conducen a la obtención de rendimientos que no corresponden con el dosaje inicial de la droga en el material vegetal fresco. Los resultados de este trabajo podrían ser de utilidad para interpretar situaciones análogas en el aislamiento de productos naturales provenientes de vegetales.; A quantitative analytic evaluation of the extraction of the natural antimalarial drug artemisinin, in wild plants of Artemisia annua L., using mixtures of ethanol 70% (v/v)-water has ben carried out. This study has been performed in order to find a justification of the reduced recovery of that drug in their isolation processes previously reported, not corresponding to the values of its dosage in the fresh plant material. The results of this work could be useful to interpret similar situations in the isolation of plant natural products.

2008-01-01T00:00:00Z Se ha realizado una evaluación analítica cuantitativa de la extracción de la droga antimalárica natural artemisinina, presente en plantas silvestres de Artemisia annua L., utilizando mezclas de etanol 70% (v/v) - agua. El objetivo ha sido encontrar una justificación de la reducida recuperación de esa droga en los procesos de su aislamiento ya indicados en la literatura y que conducen a la obtención de rendimientos que no corresponden con el dosaje inicial de la droga en el material vegetal fresco. Los resultados de este trabajo podrían ser de utilidad para interpretar situaciones análogas en el aislamiento de productos naturales provenientes de vegetales. A quantitative analytic evaluation of the extraction of the natural antimalarial drug artemisinin, in wild plants of Artemisia annua L., using mixtures of ethanol 70% (v/v)-water has ben carried out. This study has been performed in order to find a justification of the reduced recovery of that drug in their isolation processes previously reported, not corresponding to the values of its dosage in the fresh plant material. The results of this work could be useful to interpret similar situations in the isolation of plant natural products. Molina Torres, Jorge Santos Escobar, Fernando González-Arnao, María T. Ramírez-Chávez, Enrique Sánchez Pavón Esmeralda http://sedici.unlp.edu.ar:80/handle/10915/7701 2012-05-03T01:50:39Z 2008-01-01T00:00:00Z

Articulo Enzymatic synthesis of alkamides in non-aqueous systems and In vitro assay of bioactivity Latin American Journal of Pharmacy; vol. 27, no. 6 Se sintetizaron diez moléculas de alcamidas usando la enzima Novozym lipasa B de Candida antartica en tolueno anhidro. Como sustrato de la reacción se utilizaron ácidos grasos y ésteres de ácidos grasos en presencia de isobutilamina o feniletilamina. El equilibrio de las reacciones se alcanzó entre 24 y 48 h, con niveles de conversión de 35,9 a 99,2%, obteniéndose mayor efectividad de reacción utilizando feniletilamina. Los ensayos de bioactividad de ocho de las alcamidas obtenidas, sobre el crecimiento de bacterias Gram(+) reflejaron que las alcamidas con el sustituyente feniletil, son más activas que con el isobutilo. Los ensayos frente a bacterias Gram(-), no manifestaron inhibición.; Ten molecules of alkamides were synthesized using the Novozym lipase B from Candida antarctica in anhydrous toluene. Fatty acids and fatty acid esters and isobutylamine or phenylethylamine to compare their efficiency as nucloephiles. The reaction equilibrium of was achieved between 24 and 48 h, with conversion levels between 35.9 and 99.2%. Higher effectiveness was observed using phenylethylamine as nucleophyle. Bioactivity assays of eight obtained alkamides on development of Gram(+) bacteria displayed better performance when the amide group was substituted with phenylethylamine than with isobutylamine. Assays with Gram(-) bacteria did not show an inhibitor effect.

2008-01-01T00:00:00Z Se sintetizaron diez moléculas de alcamidas usando la enzima Novozym lipasa B de Candida antartica en tolueno anhidro. Como sustrato de la reacción se utilizaron ácidos grasos y ésteres de ácidos grasos en presencia de isobutilamina o feniletilamina. El equilibrio de las reacciones se alcanzó entre 24 y 48 h, con niveles de conversión de 35,9 a 99,2%, obteniéndose mayor efectividad de reacción utilizando feniletilamina. Los ensayos de bioactividad de ocho de las alcamidas obtenidas, sobre el crecimiento de bacterias Gram(+) reflejaron que las alcamidas con el sustituyente feniletil, son más activas que con el isobutilo. Los ensayos frente a bacterias Gram(-), no manifestaron inhibición. Ten molecules of alkamides were synthesized using the Novozym lipase B from Candida antarctica in anhydrous toluene. Fatty acids and fatty acid esters and isobutylamine or phenylethylamine to compare their efficiency as nucloephiles. The reaction equilibrium of was achieved between 24 and 48 h, with conversion levels between 35.9 and 99.2%. Higher effectiveness was observed using phenylethylamine as nucleophyle. Bioactivity assays of eight obtained alkamides on development of Gram(+) bacteria displayed better performance when the amide group was substituted with phenylethylamine than with isobutylamine. Assays with Gram(-) bacteria did not show an inhibitor effect. Provensi, Gustavo Nöel, François Lopes, Daniela V.S. Fenner, Raquel Betti, Andresa H. Costa, Fernanda de Morais, Everton C. Grosmann, Grace Rates, Stela M.K. http://sedici.unlp.edu.ar:80/handle/10915/7700 2012-05-03T01:50:39Z 2008-01-01T00:00:00Z

Articulo Participation of GABA-benzodiazepine Receptor Complex in the Anxiolytic Effect of Passiflora alata Curtis (Passifloraceae) Latin American Journal of Pharmacy; vol. 27, no. 6 Passiflora alata Curtis is used in Brazilian folk medicine and also by pharmaceutical industry due to its tranquilizing properties. In this work, the central activity of an aqueous (AQ) and an hydroethanolic (HE) leaves extracts were evaluated in elevated plus maze, barbiturate sleeping time, open field and [3H]flunitrazepam binding assays. The only effect presented by AQ (300 mg/kg, p.o.) was on the barbiturate sleeping time, indicating a hypnotic effect. The HE extract (300 and 600 mg/kg, p.o.) also increased the barbiturate sleeping time and reduced the locomotor activity (at 600 mg/kg, p.o.), pointing to a sedative effect. In addition HE showed an anxiolytic-like effect (300 mg/kg, p.o.) in the elevated plus maze test which was blocked by flumazenil (6 mg/kg, i.p.). Nevertheless HE did not displace [3H]flunitrazepam binding to rat brain synaptosomes in concentrations up to 1000 μg/mL. As a conclusion, we showed that the anxiolytic effect of P. alata in mice depends on the dose and solvent used for the extract preparation, and this effect cannot be attributed to the direct activation of the central benzodiazepine site by the chemical constituents of the extract. It is possible that their metabolites or an indirect effect on benzodiazepine- GABAA receptor complex mediate the observed anxiolytic effect.

2008-01-01T00:00:00Z Passiflora alata Curtis is used in Brazilian folk medicine and also by pharmaceutical industry due to its tranquilizing properties. In this work, the central activity of an aqueous (AQ) and an hydroethanolic (HE) leaves extracts were evaluated in elevated plus maze, barbiturate sleeping time, open field and [3H]flunitrazepam binding assays. The only effect presented by AQ (300 mg/kg, p.o.) was on the barbiturate sleeping time, indicating a hypnotic effect. The HE extract (300 and 600 mg/kg, p.o.) also increased the barbiturate sleeping time and reduced the locomotor activity (at 600 mg/kg, p.o.), pointing to a sedative effect. In addition HE showed an anxiolytic-like effect (300 mg/kg, p.o.) in the elevated plus maze test which was blocked by flumazenil (6 mg/kg, i.p.). Nevertheless HE did not displace [3H]flunitrazepam binding to rat brain synaptosomes in concentrations up to 1000 μg/mL. As a conclusion, we showed that the anxiolytic effect of P. alata in mice depends on the dose and solvent used for the extract preparation, and this effect cannot be attributed to the direct activation of the central benzodiazepine site by the chemical constituents of the extract. It is possible that their metabolites or an indirect effect on benzodiazepine- GABAA receptor complex mediate the observed anxiolytic effect. Pasquali, Ricardo C. Taurozzi, Melina P. Sacco, Natalia Bregni, Carlos http://sedici.unlp.edu.ar:80/handle/10915/7699 2012-05-03T01:50:40Z 2008-01-01T00:00:00Z

Articulo Latin American Journal of Pharmacy; vol. 27, no. 6 In this research, birefringent emulsions stabilized with Steareth-2 and Steareth-21 were studied. Some authors attributed to them a liquid-crystalline structure, although the microphotographs presented by them as an evidence of such structure actually suggest the presence of solid crystals instead of liquid crystals. The purposes of this paper are to determine the true cause of the birefringence of this type of emulsions and to study how the composition of the oily phase influences the stability and the birefringence. Six emulsions stabilized with a mixture of Steareth-2 and Steareth-21 were prepared, each one with a different emollient. Four of them were birefringent while two were isotropic. The observed birefringence would be due to the presence of solid crystals and not of liquid-crystals. These solid crystals could be originated by the interaction between both emulsifiers, either between themselves, with stearic acid or cetyl alcohol presents in the formulations, or even because of the insolubility of stearic acid or cetyl alcohol in emollient oil. Moreover, the isotropic emulsions showed greater viscosity than the birefringent ones. This result is accorded to the fact that the birefringence is not related to the presence of a liquid-crystalline interphase, because this type of interphase leads to an increase of viscosity.

2008-01-01T00:00:00Z In this research, birefringent emulsions stabilized with Steareth-2 and Steareth-21 were studied. Some authors attributed to them a liquid-crystalline structure, although the microphotographs presented by them as an evidence of such structure actually suggest the presence of solid crystals instead of liquid crystals. The purposes of this paper are to determine the true cause of the birefringence of this type of emulsions and to study how the composition of the oily phase influences the stability and the birefringence. Six emulsions stabilized with a mixture of Steareth-2 and Steareth-21 were prepared, each one with a different emollient. Four of them were birefringent while two were isotropic. The observed birefringence would be due to the presence of solid crystals and not of liquid-crystals. These solid crystals could be originated by the interaction between both emulsifiers, either between themselves, with stearic acid or cetyl alcohol presents in the formulations, or even because of the insolubility of stearic acid or cetyl alcohol in emollient oil. Moreover, the isotropic emulsions showed greater viscosity than the birefringent ones. This result is accorded to the fact that the birefringence is not related to the presence of a liquid-crystalline interphase, because this type of interphase leads to an increase of viscosity. Vosgerau, Milene Z. S. Soares, Darli A. Souza, Regina K. T. http://sedici.unlp.edu.ar:80/handle/10915/7698 2012-05-03T01:50:40Z 2008-01-01T00:00:00Z

Articulo Self-medication among adults in a comprehended area of one Family Health Unity Latin American Journal of Pharmacy; vol. 27, no. 6 Este artigo objetivou estimar a prevalência e os fatores associados à automedicação entre adultos de 20 a 59 anos residentes na área de abrangência de uma Unidade Saúde da Família de Ponta Grossa, Paraná, entre 2006 e 2007. A pesquisa consistiu em estudo transversal de base populacional. A seleção dos sujeitos realizou-se por amostragem sistemática. Entrevistou-se 374 pessoas. O período recordatório utilizado foi de 7 dias. Para a análise estatística utilizou-se os testes de qui-quadrado e razão de prevalência. Como resultado, a prevalência de automedicação foi de 24,9%. Foram consumidos 119 medicamentos entre aqueles que se automedicaram. Dos medicamentos citados, 43,7% eram analgésicos. A dipirona sódica foi o princípio ativo mais consumido sem prescrição. Na análise da razão de prevalência, somente o nível sócio-econômico associou-se à automedicação. A prevalência da automedicação neste trabalho foi baixa comparada com pesquisas realizadas no Brasil e semelhantes a resultados observados em outros países.; This article aimed to assess the prevalence and the factors related to self-medication among adults with ages ranging from 20 to 59 years old, living in an area attended by a Family Health Unit in Ponta Grossa, PR, between 2006 and 2007. The research consisted in a cross-sectional study in population basis. The selection of the subjects was performed according to systematic sampling. 374 people were interviewed. The recording used period was 7 days. For the statistics analysis the chi-squared test was performed and also prevalence rating. As a result, the prevalence of self-medication was 24.9%. It was consumed 119 medications among those who medicated themselves. About the cited medicines, 43.7% were painkillers. The sodic dypirone was the most consumed active principle with no prescription. In the analysis of the rate of prevalence, just the social economic level was related to self-medication. The prevalence of self-medication in this work was low when compared with researches performed in Brazil and similar to results observed in other countries.

2008-01-01T00:00:00Z Este artigo objetivou estimar a prevalência e os fatores associados à automedicação entre adultos de 20 a 59 anos residentes na área de abrangência de uma Unidade Saúde da Família de Ponta Grossa, Paraná, entre 2006 e 2007. A pesquisa consistiu em estudo transversal de base populacional. A seleção dos sujeitos realizou-se por amostragem sistemática. Entrevistou-se 374 pessoas. O período recordatório utilizado foi de 7 dias. Para a análise estatística utilizou-se os testes de qui-quadrado e razão de prevalência. Como resultado, a prevalência de automedicação foi de 24,9%. Foram consumidos 119 medicamentos entre aqueles que se automedicaram. Dos medicamentos citados, 43,7% eram analgésicos. A dipirona sódica foi o princípio ativo mais consumido sem prescrição. Na análise da razão de prevalência, somente o nível sócio-econômico associou-se à automedicação. A prevalência da automedicação neste trabalho foi baixa comparada com pesquisas realizadas no Brasil e semelhantes a resultados observados em outros países. This article aimed to assess the prevalence and the factors related to self-medication among adults with ages ranging from 20 to 59 years old, living in an area attended by a Family Health Unit in Ponta Grossa, PR, between 2006 and 2007. The research consisted in a cross-sectional study in population basis. The selection of the subjects was performed according to systematic sampling. 374 people were interviewed. The recording used period was 7 days. For the statistics analysis the chi-squared test was performed and also prevalence rating. As a result, the prevalence of self-medication was 24.9%. It was consumed 119 medications among those who medicated themselves. About the cited medicines, 43.7% were painkillers. The sodic dypirone was the most consumed active principle with no prescription. In the analysis of the rate of prevalence, just the social economic level was related to self-medication. The prevalence of self-medication in this work was low when compared with researches performed in Brazil and similar to results observed in other countries.