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dc.date.accessioned 2021-08-31T17:14:26Z
dc.date.available 2021-08-31T17:14:26Z
dc.date.issued 2009
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/123854
dc.description.abstract Oxidative stress has been involved in the development of several pathologies, including vascular damage associated to myocardial and neurological degeneration, such as arteriosclerosis, cerebral ischemia among others; while diabetes, rheumatoid arthritis, inflammation, cancer-initiation, and acceleration of the aging processes are also reported (Coyle and Puttfarcken, 1993; Margail et al., 2005). The toxicity of oxidative stress is believed to be caused by Reactive Oxygen and Nitrogen Species (ROS and RNS, respectively) that can initiate a wide range of oxidative toxic reactions in biological systems (Cuzzocrea et al., 2001). Typical radicals and radical-related toxic molecules produced by ROS are hydrogen peroxide (H2O2), hydroxyl radical (OH⋅), singlet oxygen (1O2), and superoxide anion radical (O2 ⋅-) (Figure 1). The RNS toxic reactants include nitric oxide (NO⋅) and the most powerful oxidant peroxynitrite anion (ONOO-). Biological antioxidant mechanisms described in the literature are many, but with different efficiencies implicating enzymatic as well as non-enzymatic activities. Some of the most relevant antioxidative biocatalysts are superoxide dismutase, and catalase. In addition, other specialized enzymes such as glutathione peroxidase and ã-glutamylcysteine synthetase can be involved in deactivation mechanisms (Figure 1). Well-known non-enzymatic antioxidants are b-carotene, glutathione, melatonin and vitamins C and E, (Valko et al., 2006). However, excessive and persistent formation of free radicals could be main factors of genotoxic effects. en
dc.format.extent 13-22 es
dc.language en es
dc.publisher Asiatech Publishers es
dc.subject Estrés Oxidativo es
dc.subject Oxígeno reactivo es
dc.subject Especies de Nitrógeno Reactivo es
dc.title Evaluation of antioxidant activity of emulsan in vitro en
dc.type Libro es
sedici.identifier.uri https://www.researchgate.net/publication/232769182_Evaluation_of_antioxidant_activity_of_emulsan_in_vitro es
sedici.identifier.isbn No posee es
sedici.creator.person Castro, Guillermo Raúl es
sedici.creator.person Zuluaga, Natalia es
sedici.creator.person Panilaitis, Bruce es
sedici.creator.person Kaplan, David es
sedici.description.note Trabajo presentado en International Conference on New Horizons in Biotechnology (NHBT-2007) (Trivandrum, India, November 26-29, 2007). es
sedici.subject.materias Química es
sedici.description.fulltext true es
mods.originInfo.place Centro de Investigación y Desarrollo en Fermentaciones Industriales es
mods.originInfo.place Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas es
sedici.subtype Capitulo de libro es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.contributor.compiler Pandey, A. es
sedici.contributor.compiler Larroche, C. es
sedici.contributor.compiler Soccol, C. R. es
sedici.contributor.compiler Dussap, C.-G. es
sedici.relation.bookTitle New horizons in biotechnology es

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