A small series of C-glycosides containing the methoxyaryl moieties was tested for the inhibition of the β-class carbonic anhydrases (CAs, EC 4.2.1.1) from Cryptococcus neoformans and Brucella suis. Many compounds showed activities in the micromolar or submicromolar range and excellent selectivity for pathogen CAs over human isozymes. The deprotected glycosides incorporating the 6-methoxy-2-naphthyl moiety showed the best inhibition profile and therefore represent leads for the development of novel anti-infectives with a new mechanism of action.
Información general
Fecha de publicación:7 de octubre de 2014
Idioma del documento:Inglés
Revista:Journal of Enzyme Inhibition and Medicinal Chemistry; vol. 30, no. 5
Institución de origen:Facultad de Ciencias Exactas; Laboratorio de Estudio de Compuestos Orgánicos
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