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dc.date.accessioned 2021-09-03T14:16:36Z
dc.date.available 2021-09-03T14:16:36Z
dc.date.issued 2014-10-07
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/124089
dc.description.abstract A small series of C-glycosides containing the methoxyaryl moieties was tested for the inhibition of the β-class carbonic anhydrases (CAs, EC 4.2.1.1) from Cryptococcus neoformans and Brucella suis. Many compounds showed activities in the micromolar or submicromolar range and excellent selectivity for pathogen CAs over human isozymes. The deprotected glycosides incorporating the 6-methoxy-2-naphthyl moiety showed the best inhibition profile and therefore represent leads for the development of novel anti-infectives with a new mechanism of action. en
dc.format.extent 857-861 es
dc.language en es
dc.subject Carbohydrate es
dc.subject carbonic anhydrase es
dc.subject pathogen es
dc.title C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases en
dc.type Articulo es
sedici.identifier.other pmid:25291009 es
sedici.identifier.other doi:10.3109/14756366.2014.967233 es
sedici.identifier.issn 1475-6374 es
sedici.identifier.issn 1475-6366 es
sedici.creator.person Riafrecha, Leonardo Ezequiel es
sedici.creator.person Vullo, Daniela es
sedici.creator.person Supuran, Claudiu T. es
sedici.creator.person Colinas, Pedro Alfonso es
sedici.subject.materias Ciencias Exactas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Exactas es
mods.originInfo.place Laboratorio de Estudio de Compuestos Orgánicos es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Journal of Enzyme Inhibition and Medicinal Chemistry es
sedici.relation.journalVolumeAndIssue vol. 30, no. 5 es


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