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dc.date.accessioned | 2021-09-14T19:06:22Z | |
dc.date.available | 2021-09-14T19:06:22Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/124828 | |
dc.description.abstract | Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal glucose tolerance (NGT) or PreD. In each subgroup we also identified those with/out insulin resistance (IR) measured by the triglyceride/HDL-c ratio (normal cut off values previously established in our population). Clinical and metabolic data were collected for all participants. PWV was compared between subgroups using independent t test. Results: Women and men had comparable clinical and metabolic characteristics with obesity (BMI ≥ 30) and antihypertensive-statin treatment, almost half with either NGT or PreD. Whereas 48% of NGT people presented IR (abnormally high TG/HDL-c ratio), 52% had PreD. PWV was significantly higher only in those with a complete picture of metabolic syndrome (MS). Conclusions: Since PWV was significantly impaired in people with a complete picture of MS, clinicians must carefully search for early diagnosis of this condition and prescribe a healthy life-style to prevent development/progression of CVD. This proactive attitude would provide a cost-effective preventive strategy to avoid CVD’s negative impact on patients’ quality of life and on health systems due to their higher care costs. | en |
dc.language | en | es |
dc.subject | pulse wave velocity | es |
dc.subject | OGTT | es |
dc.subject | prediabetes | es |
dc.subject | TG/HDL ratio | es |
dc.subject | dyslipidemia | es |
dc.subject | arterial stiffness | es |
dc.title | Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis | en |
dc.type | Articulo | es |
sedici.identifier.uri | https://www.mdpi.com/2077-0383/10/15/3251 | es |
sedici.identifier.other | doi:10.3390/jcm10153251 | es |
sedici.identifier.issn | 2077-0383 | es |
sedici.creator.person | Gagliardino, Juan José | es |
sedici.creator.person | Salazar, Martín R. | es |
sedici.creator.person | Espeche, Walter Gastón | es |
sedici.creator.person | Tolosa Chapasian, Paula | es |
sedici.creator.person | Gomez Garizoain, Daniela | es |
sedici.creator.person | Olano, Ricardo Daniel | es |
sedici.creator.person | Stavile, Rodolfo Nicolás | es |
sedici.creator.person | Balbín, Eduardo | es |
sedici.creator.person | Martínez, Camilo | es |
sedici.creator.person | Leiva Sisnieguez, Betty Cecilia | es |
sedici.creator.person | Leiva Sisnieguez, Carlos Enrique | es |
sedici.creator.person | Carbajal, Horacio Antonio | es |
sedici.subject.materias | Ciencias Médicas | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Centro de Endocrinología Experimental y Aplicada | es |
mods.originInfo.place | Facultad de Ciencias Médicas | es |
sedici.subtype | Articulo | es |
sedici.rights.license | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | Journal of Clinical Medicine | es |
sedici.relation.journalVolumeAndIssue | vol. 10, no. 15 | es |