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dc.date.accessioned | 2021-10-13T18:25:46Z | |
dc.date.available | 2021-10-13T18:25:46Z | |
dc.date.issued | 2021-06-29 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/126606 | |
dc.description.abstract | Brain aging is characterized by chronic neuroinflammation caused by activation of glial cells, mainly microglia, leading to alterations in homeostasis of the central nervous system. Microglial cells are constantly surveying their environment to detect and respond to diverse signals. During aging, microglia undergo a process of senescence, characterized by loss of ramifications, spheroid formation, and fragmented processes, among other abnormalities. Therefore, the study of microglia senescence is of great relevance to understand age‐related declines in cognitive and motor function.We have targeted the deleterious effects of aging by implementing gene therapy with IGF-1, employing recombinant adenoviral vectors (RAds) as a delivery system. In this study, we performed intracerebroventricular (ICV) IGF-1 gene therapy on aged female rats and evaluated its effect on Caudate-Putamen unit (CPu) gene expression and inflammatory state. IGF-1 gene therapy modified senescent microglia of the CPu towards an anti-inflammatory state increasing the proportion of Iba1 |
en |
dc.language | es | es |
dc.subject | Genetic enhancement | es |
dc.subject | Internal medicine | es |
dc.subject | Endocrinology | es |
dc.subject | Gene expression | es |
dc.subject | Caudate putamen | es |
dc.subject | Rat brain | es |
dc.subject | Biology | es |
dc.title | IGF-1 Gene Therapy Modifies Inflammatory Environment and Gene Expression in the Caudate-Putamen of Aged Female Rat Brain | en |
dc.type | Articulo | es |
sedici.identifier.other | doi:10.21203/rs.3.rs-638414/v1 | es |
sedici.creator.person | Falomir Lockhart, Eugenia | es |
sedici.creator.person | Dolcetti, Franco Juan Cruz | es |
sedici.creator.person | Herrera, Macarena Lorena | es |
sedici.creator.person | Pennini, Jerónimo | es |
sedici.creator.person | Zappa Villar, María Florencia | es |
sedici.creator.person | Salinas, Gabriela | es |
sedici.creator.person | Portiansky, Enrique Leo | es |
sedici.creator.person | Spittau, Björn | es |
sedici.creator.person | Lacunza, Ezequiel | es |
sedici.creator.person | Hereñú, Claudia Beatriz | es |
sedici.creator.person | Bellini, María José | es |
sedici.subject.materias | Biología | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Instituto de Investigaciones Bioquímicas de La Plata | es |
sedici.subtype | Preprint | es |
sedici.rights.license | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
sedici.description.peerReview | non-peer-review | es |