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dc.date.accessioned 2010-11-08T17:17:24Z
dc.date.available 2010-11-08T03:00:00Z
dc.date.issued 2010 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8032
dc.description.abstract Crude drug and different extracts of Achyrocline satureioides (Lam.) DC., A. tomentosa Rusby, Gnaphalium cheiranthifolium Lam. and G. gaudichaudianum DC. (Gnaphalieae: Asteraceae) are widely used in South America mainly as digestives and hepatics. These are raw material for phytotherapics preparations and the manufacture of traditional bitter drinks. In order to establish some aspects on their safety, we have evaluated four different concentrations (1, 10, 100, and 1000 µL.mL-1) of the aqueous extracts of these plants against Single Cell Gel Electrophoresis Assay (SCGEA) in human peripheral blood lymphocytes. Results show a significant increase in damage index (p < 0.001) for all aqueous extracts concentrations assayed of the four plant species, in relation to negative control values. This is a contribution to the development of screenings related to the potential health risk associated with the consumption of South American medicinal plants, especially taking in mind that these plants are widely used as over-thecounter herbs. es
dc.format.extent 1088-1092 es
dc.language en es
dc.subject Achyrocline; comet assay; DNA damage; genotoxicity; gnaphalium es
dc.title Genotoxic effect of aqueous extracts from South American Achyrocline and Gnaphalium species (Asteraceae: Gnaphalieae) on human lymphocytes es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_5.pdf es
sedici.creator.person Carballo, Marta A. es
sedici.creator.person Cortada, Catalina M. es
sedici.creator.person Gadano, Andrea B. es
sedici.creator.person Del Vitto, Luis A. es
sedici.creator.person Petenatti, Elisa M. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001519 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 29, no. 7 es

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