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dc.date.accessioned 2011-04-27T11:28:41Z
dc.date.available 2011-04-27T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://hdl.handle.net/10915/8172
dc.description.abstract The objective of the present study was to minimize the unwanted toxic effects of antihypertensive drug diltiazem hydrochloride (DTZ) by kinetic control of drug release from microparticles using chemically modified locust bean gum (MLGB) as carrier by emulsification method. DTZ was entrapped into gastro resistant, biodegradable locust bean gum microparticles using emulsification method. Solid, discrete, reproducible free flowing microparticles were obtained. The yield of the microparticles was up to 95 %. More than 97 % of the isolated microparticles were of particle size range of 325 to 455 µm. The obtained angle of repose, % Carr index and tapped density values were well within the limits, indicating that prepared microparticles had smooth surface, free flowing and good packing properties. Scanning Electron Microscopy photographs and calculated sphericity factor confirms that the prepared formulations are spherical in nature. Prepared microparticles were stable and compatible, as confirmed by DSC and FT-IR studies. It was observed that there is no significant release of the drug at gastric pH. The drug release was controlled more than 12 h. Intestinal drug release from microparticles was studied and compared with the release behavior of commercially available oral formulation Cardizam® CD. The release kinetics followed different transport mechanisms. es
dc.format.extent p. 519-526 es
dc.language en es
dc.title Development and evaluation of modified locust bean microparticles for controlled drug delivery es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_16.pdf es
sedici.creator.person Gowda, D. Vishakant es
sedici.creator.person Gupta, N. Vishal es
sedici.creator.person Khan, Mohammed S. es
sedici.creator.person Singh, Mangla N. es
sedici.subject.materias Farmacia es
sedici.subject.decs Sistemas de Liberación de Medicamentos es
sedici.subject.decs Agentes Antihipertensivos es
sedici.subject.keyword microparticles; diltiazem hydrochloride; modified locust bean gum; release kinetics es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001659 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 3 es

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