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dc.date.accessioned 2011-04-27T17:10:06Z
dc.date.available 2011-04-27T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8178
dc.description.abstract The aim of this study was to validate an agar diffusion method through the parameters linearity, precision and accuracy, to quantify apramycin in soluble powder. The calibration curve of apramycin was constructed by plotting log of concentrations (µg ml-1) versus zone diameter (mm) and shows good linearity in the range of 1.0-4.0 µg ml-1. The precision of the assay was determined by assaying samples at the same day (repeatability - R.S.D. = 2.00%) and on different days (intermediate precision - R.S.D. = 5.06%) and indicate good precision. The accuracy expresses the agreement between the accepted value and the value found. The mean recovery was found to be 100.49 % for apramycin soluble powder. The results indicated that the microbiological assay proposed in this work hold linearity, precision and accuracy being an acceptable alternative method for routine quality control of apramycin in the pharmaceutical dosage form studied. es
dc.format.extent 554-557 es
dc.language en es
dc.subject agar diffusion method; apramycin; microbiological assay es
dc.subject Técnicas y Procedimientos de Laboratorio es
dc.subject Pruebas de Sensibilidad Microbiana es
dc.title Microbiological assay for apramycin soluble powder es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_2_3.pdf es
sedici.creator.person Lourenço, Felipe R. es
sedici.creator.person Barbosa, Elisabete A. es
sedici.creator.person Pinto, Terezinha J. A. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001665 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 3 es


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