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dc.date.accessioned 2011-12-14T15:19:44Z
dc.date.available 2011-12-14T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://hdl.handle.net/10915/8357
dc.description.abstract This study reports the cytotoxicity screening of 33 coumarins in a panel of human tumor cell lines (Caco-2: human colorectal adenocarcinoma, HCT-8: human ileocecal adenocarcinoma, and HEp-2: human larynx epidermoid carcinoma). The classic MTT assay was employed to evaluate the influence of samples on cellular viability. Following continuous incubation with cells for 72 h, all tested coumarins exhibited CC50 values ≥ 0.34 mM for all three cell lines. These findings indicate that all samples were not able to reduce the viability of tumor cell lines used in this study in clinically relevant concentrations. Some structure-activity relationships were established and could be used for the synthesis of derivatives with improved cytotoxic potential. es
dc.format.extent p. 1669-167 es
dc.language en es
dc.title In vitro cytotoxic screening of coumarins es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_1.pdf es
sedici.creator.person Montagner, Cristina es
sedici.creator.person Savi, Luciane A. es
sedici.creator.person Silva, Izabella T. es
sedici.creator.person Kratz, Jadel M. es
sedici.creator.person Smânia, Elza F. A. es
sedici.creator.person Monache, Franco D. es
sedici.creator.person Smânia Junior, Artur es
sedici.creator.person Simões, Cláudia Maria Oliveira es
sedici.subject.materias Farmacia es
sedici.subject.decs Pruebas Inmunológicas de Citotoxicidad es
sedici.subject.decs Cumarinas es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici2003.identifier ARG-FARM-ART-0000001844 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 9 es


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