http://sedici.unlp.edu.ar:80/handle/10915/148 2026-10-23T02:26:02Z 2026-10-23T02:26:02Z Camps, Elena http://sedici.unlp.edu.ar:80/handle/10915/6947 2013-10-17T12:02:29Z 2001-01-01T00:00:00Z

Articulo Suggestions of norms of operation for municipal deposits of drugs, biomedical materials and diagnosis kits for in vitro use Acta Farmacéutica Bonaerense; vol. 20, no. 1 El propósito de este trabajo es sugerir una legislación específica para el funcionamiento de un depósito municipal, distribuidor de insumos médicos, ya que su falta afecta la actividad de los mismos, poniendo en riesgo la salud de la población. Fue analizada la legislación vigente observándose un vacío en el ámbito de la salud pública a nivel de la atención primaria.En la actualidad, en la mayoría de los casos estos depósitos proveen medicamentos, materiales biomédicos y reactivos de diagnóstico sin habilitación y sin un farmacéutico a cargo. Una legislación específica traerá como consecuencia un consumo racional de medicamentos, una mayor equidad y eficiencia de los servicios farmacéuticos y un ahorro en padecimientos humanos. Todo esto se puede hacer con un mayor control farmacéutico, lo cual es posible si se cuenta con suficientes profesionales para cubrir los cargos que estos centros necesitan; The purpose of this paper is to suggest a specific legislation for the operation of a municipal deposit, distributor of medical inputs, since its lack affects their activity, endangering the population's health. The prevailing legislation was analyzed and a gap was noted in the field of the public health at the level of the primary attention. At the present time, in most cases these deposits provide drugs, biomedical materials and diagnosis kits for in vitro use without authorization and without a pharmacist in charge. A specific legislation will result in a rational consumption of drugs, a higher equity and efficiency of the pharmaceutical services and a saving in human suffering. According to what it has been set out above, the aim can be achieved by means of a higher pharmaceutical control, which is possible if enough professioiials are available to cover all the positions these centers require.

2001-01-01T00:00:00Z El propósito de este trabajo es sugerir una legislación específica para el funcionamiento de un depósito municipal, distribuidor de insumos médicos, ya que su falta afecta la actividad de los mismos, poniendo en riesgo la salud de la población. Fue analizada la legislación vigente observándose un vacío en el ámbito de la salud pública a nivel de la atención primaria.En la actualidad, en la mayoría de los casos estos depósitos proveen medicamentos, materiales biomédicos y reactivos de diagnóstico sin habilitación y sin un farmacéutico a cargo. Una legislación específica traerá como consecuencia un consumo racional de medicamentos, una mayor equidad y eficiencia de los servicios farmacéuticos y un ahorro en padecimientos humanos. Todo esto se puede hacer con un mayor control farmacéutico, lo cual es posible si se cuenta con suficientes profesionales para cubrir los cargos que estos centros necesitan The purpose of this paper is to suggest a specific legislation for the operation of a municipal deposit, distributor of medical inputs, since its lack affects their activity, endangering the population's health. The prevailing legislation was analyzed and a gap was noted in the field of the public health at the level of the primary attention. At the present time, in most cases these deposits provide drugs, biomedical materials and diagnosis kits for in vitro use without authorization and without a pharmacist in charge. A specific legislation will result in a rational consumption of drugs, a higher equity and efficiency of the pharmaceutical services and a saving in human suffering. According to what it has been set out above, the aim can be achieved by means of a higher pharmaceutical control, which is possible if enough professioiials are available to cover all the positions these centers require. Delvecchio, Edith E. Domosbian, Daniel E. http://sedici.unlp.edu.ar:80/handle/10915/6946 2013-10-17T12:02:29Z 2001-01-01T00:00:00Z

Articulo Nimesulide is not a safe drug Acta Farmacéutica Bonaerense; vol. 20, no. 1 La nimesulida es una droga con muchas restricciones en su uso en Europa por la falta de datos sobre la seguridad y eficacia. En Argentina se la emplea como un antiinflamatorio de amplio espectro, hasta como antifebril, inclusive en niños. El presente estudio tiene el objetivo de comparar los prospectos de las diferentes especialidades que contienen nimesulida tanto en nuestro país como en países europeos donde se la comercializa y confrontar esa información con bibliografía sobre la seguridad de la droga obtenida de bases de datos existentes en el Centro de Información de Medicamentos Farmacéutico del Colegio de Farmacéuticos de la Provincia de Buenos Aires, Argentina. Existen numerosos informes de efectos adversos hepáticos y renales severos e inclusive fatales, no siempre declarados en la información que brindan los laboratori&. Por eso la falta de regulación en su comercialización y prescripción es una amenaza potencial para la salud pública.; The use of Nimesulide in Europe is closely restricted because of the shortage of data about its safety and efficacy. In Argentina it is used as a broad spectrum anti-inflammatory drug, even as an antipiretic oiie, iiicluding its use iii children. The present study aims to compare the prospects of the different medicinal specialities coiitainiiig iiimesulide wliicli are coinmercialized in our country as well as in Europeati ones, and to collate tliis infomiation with bibliography about the safety of the drug obtained from data bases at the Pliarmaceutical Drug Inforrnation Ceiiter of the College of Pharmacists of the Province of Buenos Aires. There is a number of reports referring to hepatic and renal adverse reactions, soine of them are severe and still fatal ones which in matiy cases are iiot declared iii the information froin the inanufacturers. That is why the lack of regulatioii of iiiinesulide coinmercialization and prescription is a potential threat for public health.

2001-01-01T00:00:00Z La nimesulida es una droga con muchas restricciones en su uso en Europa por la falta de datos sobre la seguridad y eficacia. En Argentina se la emplea como un antiinflamatorio de amplio espectro, hasta como antifebril, inclusive en niños. El presente estudio tiene el objetivo de comparar los prospectos de las diferentes especialidades que contienen nimesulida tanto en nuestro país como en países europeos donde se la comercializa y confrontar esa información con bibliografía sobre la seguridad de la droga obtenida de bases de datos existentes en el Centro de Información de Medicamentos Farmacéutico del Colegio de Farmacéuticos de la Provincia de Buenos Aires, Argentina. Existen numerosos informes de efectos adversos hepáticos y renales severos e inclusive fatales, no siempre declarados en la información que brindan los laboratori&. Por eso la falta de regulación en su comercialización y prescripción es una amenaza potencial para la salud pública. The use of Nimesulide in Europe is closely restricted because of the shortage of data about its safety and efficacy. In Argentina it is used as a broad spectrum anti-inflammatory drug, even as an antipiretic oiie, iiicluding its use iii children. The present study aims to compare the prospects of the different medicinal specialities coiitainiiig iiimesulide wliicli are coinmercialized in our country as well as in Europeati ones, and to collate tliis infomiation with bibliography about the safety of the drug obtained from data bases at the Pliarmaceutical Drug Inforrnation Ceiiter of the College of Pharmacists of the Province of Buenos Aires. There is a number of reports referring to hepatic and renal adverse reactions, soine of them are severe and still fatal ones which in matiy cases are iiot declared iii the information froin the inanufacturers. That is why the lack of regulatioii of iiiinesulide coinmercialization and prescription is a potential threat for public health. Lima, Leonardo R.P. Oliveira, Tania Toledo de Nagem, Tanus Jorge Silva Pinto, Aloisio da Stringhetta, Paulo C. Oliveira, María G. A. Tinoco, Adelson L. A. Oliveira, Marly L. Silva, José F. http://sedici.unlp.edu.ar:80/handle/10915/6945 2013-10-17T12:02:29Z 2001-01-01T00:00:00Z

Articulo Control of hyperlipidemia in treated rabbits with flavonoids and natural dyes of urucum Acta Farmacéutica Bonaerense; vol. 20, no. 1 Tendo em vista que a hiperlipidemia se constitui em fator de risco para o sistema cardiocirculatório, levando ao aparecimento da aterosclerose, o presente trabalho foi desenvolvido, objetivando o controle de lipídeos com os flavonóides luteolina e apigenina, bem como do corante natural do urucum, bixina 30% e bixina 95%, em coelhos hiperlipidemicos induzidos com triton. Decorridos 20 horas da aplicação o triton, foram administrados os compostos na dose de 10 mmol/Kg e, 24 horas após, dosados no soro dos animais, colesterol total, colesterol-HDL e triacilgliceróis. Os resultados mostram que os tratamentos foram eficazes em reduzir os níveis de colesterol total; a exceção de bixina 30%, mantiveram os níveis elevados de colesterol-HDL e a bixina 30% diminuiu significativamente os valores de triacilgliceróis.; The hyperlipidaemia is a risk factor for the development of atherosclerosis in the cardiovascular system. The present work evaluated the effects of three compounds isolated from the urucum, the flavonoids luteolin and apigenin and the natural coloring bixin (30% and 95%), on the control of serum lipids in triton-induced hyperlipidaemic rabbits. After 20 hours triton 300mg/Kg weight was administered intraperitoneal(i.p.) the rabbits were injected ¡.p. with bixin 30%. bixiii 95%, luteolin or apigenin at the dose of 10 mmol/Kg weigth. 24 hours latter total cholesterol. cholesterol-HDL and triacylglycerols were dosed in the serum of the animals. The results showed that all compounds were effective in reducing the levels of total cholesterol. Except bixin 30% the treatments incresed the levels of cholesterol-HDL, notably apigenin by about three fold. Bixine 30% was the only treatment that reduced the levels of tracylglicerols. It may be suggested that these natural compounds may have beneficial effects in controlling serum lipids levels when used as flavoring or coloring of foods.

2001-01-01T00:00:00Z Tendo em vista que a hiperlipidemia se constitui em fator de risco para o sistema cardiocirculatório, levando ao aparecimento da aterosclerose, o presente trabalho foi desenvolvido, objetivando o controle de lipídeos com os flavonóides luteolina e apigenina, bem como do corante natural do urucum, bixina 30% e bixina 95%, em coelhos hiperlipidemicos induzidos com triton. Decorridos 20 horas da aplicação o triton, foram administrados os compostos na dose de 10 mmol/Kg e, 24 horas após, dosados no soro dos animais, colesterol total, colesterol-HDL e triacilgliceróis. Os resultados mostram que os tratamentos foram eficazes em reduzir os níveis de colesterol total; a exceção de bixina 30%, mantiveram os níveis elevados de colesterol-HDL e a bixina 30% diminuiu significativamente os valores de triacilgliceróis. The hyperlipidaemia is a risk factor for the development of atherosclerosis in the cardiovascular system. The present work evaluated the effects of three compounds isolated from the urucum, the flavonoids luteolin and apigenin and the natural coloring bixin (30% and 95%), on the control of serum lipids in triton-induced hyperlipidaemic rabbits. After 20 hours triton 300mg/Kg weight was administered intraperitoneal(i.p.) the rabbits were injected ¡.p. with bixin 30%. bixiii 95%, luteolin or apigenin at the dose of 10 mmol/Kg weigth. 24 hours latter total cholesterol. cholesterol-HDL and triacylglycerols were dosed in the serum of the animals. The results showed that all compounds were effective in reducing the levels of total cholesterol. Except bixin 30% the treatments incresed the levels of cholesterol-HDL, notably apigenin by about three fold. Bixine 30% was the only treatment that reduced the levels of tracylglicerols. It may be suggested that these natural compounds may have beneficial effects in controlling serum lipids levels when used as flavoring or coloring of foods. Amaral da Silva, Francilene Petrovick, Pedro Ros Langeloh, Augusto http://sedici.unlp.edu.ar:80/handle/10915/6944 2013-10-17T12:02:29Z 2001-01-01T00:00:00Z

Articulo Effect of freeze-died extract of Portulaca pilosa L. (Portulacaceae) on uterine activity of oxytocin on Wistar mice Acta Farmacéutica Bonaerense; vol. 20, no. 1 O presente trabalho objetivou a obtenção e caracterização do extrato seco liofilizado de partes aéreas de Portulaca pilosa (ESLP) e a avaliação do efeito deste sobre a reatividade uterina de ratas Wistar. A solução extrativa de P. pilosa (SEP) foi obtida por percolação simples com etanol 80% (V/V) , utilizando uma proporção droga-solvente de 1:13 (m/V). Todas as etapas do ESLP foram caracterizadas tecnologicamente e monitoradas por cromatografia em camada delgada (CCD). Os resultados obtidos após a caracterização da matéria-prima vegetal, SEP e ESLP demonstraram que náo houve alterações qualitativas na composição química da matéria-prima vegetal e que o produto obtido apresentou-se viável para a realização dos ensaios in vitro. Os resultados do ensaio de útero isolado de rata mostraram que o ESLP provocou um antagonismo do tipo misto, de forma concentração dependente, reduzindo o efeito máximo (E_máx) e deslocando para direita as curvas concentração-efeito induzidas por oxitocina, não sustentando, assim, o uso popular desta espécie como agente abortivo; Portulaca pilosa L. (ainor-crescido) is commonly used in folk medicine to treat gastrointestinal disorders, as diuretic, scaring, analgesic, emmenagogue and abortifacient. The purposed of this work was to develop and characterize the freeze-died extract from aerial parts of Portulaca pilosa (FDEP) and to evaluale the effects on rat isolated uterus. The extractive solution of Portulaca pilosa (ESP) was obtained by simple percolation with ethanol 80% (V/V) in a 1:13 plant:solvent ratio. The obtention of FDEP was monitored by thin layer chromatography (TLC), to detect chemical changes due to the extraction and drying procedures. The results showed that the extract characteristics were adequate to the toxicological evaluation. The FDEP promoted both a dose-dependenit rightward displacement and a flattening of oxytocin concentration-respolise curves (CRC). Oxytocin CRC showed a rightward displacement of 1,60 pD2 units (at 0,25 mg.ml-1 of the extract) corresponding to a desensitization of 39,8 times. The maximal contraction was reduced to 45,6% of the corresponding control curve leading to a calculation of a IC50 of O, 11 mg.mL-l. From these results it can be concluded that the folk use as abortive or infertilizing agent is not justified.

2001-01-01T00:00:00Z O presente trabalho objetivou a obtenção e caracterização do extrato seco liofilizado de partes aéreas de Portulaca pilosa (ESLP) e a avaliação do efeito deste sobre a reatividade uterina de ratas Wistar. A solução extrativa de P. pilosa (SEP) foi obtida por percolação simples com etanol 80% (V/V) , utilizando uma proporção droga-solvente de 1:13 (m/V). Todas as etapas do ESLP foram caracterizadas tecnologicamente e monitoradas por cromatografia em camada delgada (CCD). Os resultados obtidos após a caracterização da matéria-prima vegetal, SEP e ESLP demonstraram que náo houve alterações qualitativas na composição química da matéria-prima vegetal e que o produto obtido apresentou-se viável para a realização dos ensaios in vitro. Os resultados do ensaio de útero isolado de rata mostraram que o ESLP provocou um antagonismo do tipo misto, de forma concentração dependente, reduzindo o efeito máximo (E_máx) e deslocando para direita as curvas concentração-efeito induzidas por oxitocina, não sustentando, assim, o uso popular desta espécie como agente abortivo Portulaca pilosa L. (ainor-crescido) is commonly used in folk medicine to treat gastrointestinal disorders, as diuretic, scaring, analgesic, emmenagogue and abortifacient. The purposed of this work was to develop and characterize the freeze-died extract from aerial parts of Portulaca pilosa (FDEP) and to evaluale the effects on rat isolated uterus. The extractive solution of Portulaca pilosa (ESP) was obtained by simple percolation with ethanol 80% (V/V) in a 1:13 plant:solvent ratio. The obtention of FDEP was monitored by thin layer chromatography (TLC), to detect chemical changes due to the extraction and drying procedures. The results showed that the extract characteristics were adequate to the toxicological evaluation. The FDEP promoted both a dose-dependenit rightward displacement and a flattening of oxytocin concentration-respolise curves (CRC). Oxytocin CRC showed a rightward displacement of 1,60 pD2 units (at 0,25 mg.ml-1 of the extract) corresponding to a desensitization of 39,8 times. The maximal contraction was reduced to 45,6% of the corresponding control curve leading to a calculation of a IC50 of O, 11 mg.mL-l. From these results it can be concluded that the folk use as abortive or infertilizing agent is not justified. Horwat Delaporte, Rosemeres Martínez Sánchez, Gregorio Cuéllar Cuéllar, Armando Mello, João Carlos Palazzo de http://sedici.unlp.edu.ar:80/handle/10915/6943 2016-03-30T17:40:29Z 2001-01-01T00:00:00Z

Articulo Quality control and antiinflamatory activity of the plant drugs Alternanthera brasiliana (L.) Kuntze and Bouchea fluminensis (Vell.) Mold. Acta Farmacéutica Bonaerense; vol. 20, no. 1 Las especies Alternanthera brasiliana y Bouchea fluminensis son dos plantas muy comunes en la parte sur de América del Sur y son ampliamente utilizadas por la población nativa en el tratamiento de diversas enfermedades. Hasta el momento no se ha realizado el control de calidad farmacognóstico de los extractos obtenidos de estas plantas. Por otra parte, a los extractos de Bouchea fluminensis no se les han realizado los ensayos para probar su potencial actividad antiinflamatoria. Por tanto, en este trabajo se realizó el control farmacognóstico a ambas especies, de acuerdo con los métodos indicados en las farmacopeas. Las plantas fueron recolectadas a mediados de cada estación del año. Además, se evaluó la actividad antiinflamatoria del extracto acuoso total de las hojas de B. fluminensis y de A. brasiliana. En vista de que B. fluminensis mostró una actividad farmacológica significativa sobre el edema inducido por carragenina en pata de rata, se realizó un ensayo biomonitoreado partiendo de los extractos semipurificados.; Alternanthera brasiliana and Bouchea fluminensis are medicinal plants which grow commonly in the southern part of South America and are widely used by native population to treat several diseases. The pharmacognostic quality control to the extracts obtained from these plants has not been yet performed. On the other hand, the extracts of B. fluminensis have not been previously tested for antiinflaminatory activity. Therefore, the aim of this study was to perform a pharinacognostic control to both plants according to the methods described in the pharmacopoeia. Leaves were collected about the middle of each season of the year. In addition, the antiinflammatory activity of total aqueous extracts of B.fluminensis and A. brasiliana was evaluated. In view that B.fluminensis showed a significant pharmacological activity in carrageenan-induced rat paw edema, we performed a bio-monitored assay with semi-purified extracts of the plant.

2001-01-01T00:00:00Z Las especies Alternanthera brasiliana y Bouchea fluminensis son dos plantas muy comunes en la parte sur de América del Sur y son ampliamente utilizadas por la población nativa en el tratamiento de diversas enfermedades. Hasta el momento no se ha realizado el control de calidad farmacognóstico de los extractos obtenidos de estas plantas. Por otra parte, a los extractos de Bouchea fluminensis no se les han realizado los ensayos para probar su potencial actividad antiinflamatoria. Por tanto, en este trabajo se realizó el control farmacognóstico a ambas especies, de acuerdo con los métodos indicados en las farmacopeas. Las plantas fueron recolectadas a mediados de cada estación del año. Además, se evaluó la actividad antiinflamatoria del extracto acuoso total de las hojas de B. fluminensis y de A. brasiliana. En vista de que B. fluminensis mostró una actividad farmacológica significativa sobre el edema inducido por carragenina en pata de rata, se realizó un ensayo biomonitoreado partiendo de los extractos semipurificados. Alternanthera brasiliana and Bouchea fluminensis are medicinal plants which grow commonly in the southern part of South America and are widely used by native population to treat several diseases. The pharmacognostic quality control to the extracts obtained from these plants has not been yet performed. On the other hand, the extracts of B. fluminensis have not been previously tested for antiinflaminatory activity. Therefore, the aim of this study was to perform a pharinacognostic control to both plants according to the methods described in the pharmacopoeia. Leaves were collected about the middle of each season of the year. In addition, the antiinflammatory activity of total aqueous extracts of B.fluminensis and A. brasiliana was evaluated. In view that B.fluminensis showed a significant pharmacological activity in carrageenan-induced rat paw edema, we performed a bio-monitored assay with semi-purified extracts of the plant. Cambi, Viviana N. Hermann, Paula http://sedici.unlp.edu.ar:80/handle/10915/6942 2018-03-05T16:32:00Z 2001-01-01T00:00:00Z

Articulo The sale of medicinal herbs in the district of Bahía Blanca, Argentina Acta Farmacéutica Bonaerense; vol. 20, no. 1 Se ha realizado una encuesta sobre el expendio de plantas medicinales en el partido de Bahía Blanca. En la mayoría de los comercios sólo del 10 al 30% de los clientes adquieren hierbas medicinales. Son más de 70 las especies vendidas: tilo (84,2% de los casos), manzanilla (74,3%), sen (69,3%), boldo (64,4%), cuasia, malva (47%), carqueja, valeriana (30%), cedrón (26,7%), ambay, cola de caballo y fucus (20%) son las más vendidas. En una gran proporción los clientes solicitan asesoramiento. Casi el 80% de los expendedores ha notado un vuelco hacia el uso de plantas medicinales en los últimos siete anos. El 25 % de los compradores de hierbas medicinales ha declarado haber tenido problemas por el uso incorrecto de las mismas.; A survey about the sale of medicinal plants in the district of Bahía Blanca has been carried out. In most stores, medicinal plants are bought by 10-30% of the customers. More than 70 species are sold: linden tree (84.2%); chamomile (74.3%); senna (69.3%); boldo (64.4%); quassia, mallow (47%); carqueja, valerian (30%); luisa (26.7%); ambay, horsetail, and fucus (20%) are the species more sold. A great proportion of the customers requests advice. Almost 80% of the retailers have noticed an overturn toward the use of medicinal plants in the last seven years. Twenty-five percent of the users of medicinal plants have had problems because of incorrect use.

2001-01-01T00:00:00Z Se ha realizado una encuesta sobre el expendio de plantas medicinales en el partido de Bahía Blanca. En la mayoría de los comercios sólo del 10 al 30% de los clientes adquieren hierbas medicinales. Son más de 70 las especies vendidas: tilo (84,2% de los casos), manzanilla (74,3%), sen (69,3%), boldo (64,4%), cuasia, malva (47%), carqueja, valeriana (30%), cedrón (26,7%), ambay, cola de caballo y fucus (20%) son las más vendidas. En una gran proporción los clientes solicitan asesoramiento. Casi el 80% de los expendedores ha notado un vuelco hacia el uso de plantas medicinales en los últimos siete anos. El 25 % de los compradores de hierbas medicinales ha declarado haber tenido problemas por el uso incorrecto de las mismas. A survey about the sale of medicinal plants in the district of Bahía Blanca has been carried out. In most stores, medicinal plants are bought by 10-30% of the customers. More than 70 species are sold: linden tree (84.2%); chamomile (74.3%); senna (69.3%); boldo (64.4%); quassia, mallow (47%); carqueja, valerian (30%); luisa (26.7%); ambay, horsetail, and fucus (20%) are the species more sold. A great proportion of the customers requests advice. Almost 80% of the retailers have noticed an overturn toward the use of medicinal plants in the last seven years. Twenty-five percent of the users of medicinal plants have had problems because of incorrect use. González Hernández, Rolando Lora García, Janet González Lavaut, José Antonio Sordo Martínez, Liset Rivera Grau, Jacqueline http://sedici.unlp.edu.ar:80/handle/10915/6941 2013-10-17T12:02:29Z 2001-01-01T00:00:00Z

Articulo Retrospective validation of spectrophotometric techniques for the quantitative determination of prostaglandins A2 and B2 from Plexaura homomalla extracts Acta Farmacéutica Bonaerense; vol. 20, no. 1 En este trabajo se describe la validación retrospectiva de las técnicas analíticas espectrofotométricas que han sido empleadas tradicionalmente en la determinación cuantitativa de las prostaglandinas A2 y B2 en extractos de Plexaura homomalla. Con este fin se evaluaron los parámetros de linealidad, sensibilidad, precisión, exactitud y selectividad, seleccionados de acuerdo a la clasificación del método analítico. Los resultados obtenidos demuestran que las técnicas no son fiables para cumplir con el fin propuesto. Por esta razón se discute el empleo de la cromatografia gaseosa en el análisis de prostaglandinas, de tal manera que se logren resultados cuantitativos con un nivel de confiabilidad aceptable.; The retrospective validation of the spectrophotometric analytical techniques, used historically in the quantitative determination of prostaglandins A2 and B2 in Plexaura homomalla extracts, is described in this paper. Analytical parameters, such as: linearity, sensitivity, precision, accuracy and selectivity, chosen according pharmacopoeial requirements, were evaluated. The obtained results shown that the techniques are not reliable to achieve the intended purposes. For this reason, the use of gas chromatography is discussed to assure a reliable quantitative leve1 of acceptance.

2001-01-01T00:00:00Z En este trabajo se describe la validación retrospectiva de las técnicas analíticas espectrofotométricas que han sido empleadas tradicionalmente en la determinación cuantitativa de las prostaglandinas A2 y B2 en extractos de Plexaura homomalla. Con este fin se evaluaron los parámetros de linealidad, sensibilidad, precisión, exactitud y selectividad, seleccionados de acuerdo a la clasificación del método analítico. Los resultados obtenidos demuestran que las técnicas no son fiables para cumplir con el fin propuesto. Por esta razón se discute el empleo de la cromatografia gaseosa en el análisis de prostaglandinas, de tal manera que se logren resultados cuantitativos con un nivel de confiabilidad aceptable. The retrospective validation of the spectrophotometric analytical techniques, used historically in the quantitative determination of prostaglandins A2 and B2 in Plexaura homomalla extracts, is described in this paper. Analytical parameters, such as: linearity, sensitivity, precision, accuracy and selectivity, chosen according pharmacopoeial requirements, were evaluated. The obtained results shown that the techniques are not reliable to achieve the intended purposes. For this reason, the use of gas chromatography is discussed to assure a reliable quantitative leve1 of acceptance. Petenatti, Elisa M. Petenatti, Marta E. Del Vitto, Luis A. http://sedici.unlp.edu.ar:80/handle/10915/6940 2013-10-17T12:02:29Z 2001-01-01T00:00:00Z

Articulo Pharmacognostic studies on two Argentinian species of Valeriana (Valerianaceae): V. ferax and V.polybotrya Acta Farmacéutica Bonaerense; vol. 20, no. 1 Se ha llevado a cabo el estudio micromorfológico foliar, peciolar, caulinar y radical, y han sido determinados los parámetros micrométricos de dos especies de Valeriana (Valerianaceae) halladas en San Luis, Argentina: V. polybdrya (Griseb.) Hock y V. ferax (Griseb.) Hock, encontrándose diferencias significativas entre ellas. Raíces y rizomas de ambas entidades son utilizados en sustitución de V. officinalis (codificada en la Farmacopea Nacional Argentina), pero a diferencia de ésta carecen de almidón y muestran traqueidas con puntuaciones areoladas. Con fines terapéuticos similares, las partes aéreas de las dos especies de San Luis son empleadas en medicina popular, siendo diferenciables por algunos parámetros micrométricos foliares: número de estomas del hipofilo, índice de estomas del epifilo, relación de empalizada y número de terminales de nerviación.; Micromorphologic (foliar, petiolar, caulinar and radical) features, as well as foliar micrometric parameters of two entities of Valeriana found in San Luis province, Argentina. V. polybotrya (Griseb.) Höck and V. ferax (Griseb.) Höck, have been analyzed and determined. Significant differences have been found among them. Roots and rhizomes of both species are used in substitution of V. officinalis which is codified in Argentinian Pharmacopoeia, but they have no starch and show tracheids provided with areolate punctuations. Aerial parts of both native species are popularly used with similar therapeuthical purposes, but they can be recognized by some foliar micrometric parameters: hypophyllum stomata number, epiphyllum stomata index, palisade ratio and nervure terminal number. El presente trabajo integra un plan de Tesis de Maestría en Ciencias Químico-Farmacéuticas de la Facultad de Química, Bioquímica y Farmacia de la UNSL

2001-01-01T00:00:00Z Se ha llevado a cabo el estudio micromorfológico foliar, peciolar, caulinar y radical, y han sido determinados los parámetros micrométricos de dos especies de Valeriana (Valerianaceae) halladas en San Luis, Argentina: V. polybdrya (Griseb.) Hock y V. ferax (Griseb.) Hock, encontrándose diferencias significativas entre ellas. Raíces y rizomas de ambas entidades son utilizados en sustitución de V. officinalis (codificada en la Farmacopea Nacional Argentina), pero a diferencia de ésta carecen de almidón y muestran traqueidas con puntuaciones areoladas. Con fines terapéuticos similares, las partes aéreas de las dos especies de San Luis son empleadas en medicina popular, siendo diferenciables por algunos parámetros micrométricos foliares: número de estomas del hipofilo, índice de estomas del epifilo, relación de empalizada y número de terminales de nerviación. Micromorphologic (foliar, petiolar, caulinar and radical) features, as well as foliar micrometric parameters of two entities of Valeriana found in San Luis province, Argentina. V. polybotrya (Griseb.) Höck and V. ferax (Griseb.) Höck, have been analyzed and determined. Significant differences have been found among them. Roots and rhizomes of both species are used in substitution of V. officinalis which is codified in Argentinian Pharmacopoeia, but they have no starch and show tracheids provided with areolate punctuations. Aerial parts of both native species are popularly used with similar therapeuthical purposes, but they can be recognized by some foliar micrometric parameters: hypophyllum stomata number, epiphyllum stomata index, palisade ratio and nervure terminal number. Athayde, Margareth L. Schenkel, Eloir Paulo Gnoatto, Simone B. Gosmann, Grace Giberti, Gustavo C. Guillaume, Dominique http://sedici.unlp.edu.ar:80/handle/10915/6939 2013-10-17T12:02:29Z 2001-01-01T00:00:00Z

Articulo Triterpenes and saponins from Ilex argentina leaves Acta Farmacéutica Bonaerense; vol. 20, no. 1 Ilex argentina es una de las especies que ha sido mencionada como adulterante o sustituto de la yerba mate verdadera (l. paraguariensis). De las hojas fueron aisladas dos saponinas y un triterteno y sus estructuras químicas elucidadas a través de métodos espectroscópicos. El triterpeno fue identificado como el ácido rotúndico y las saponitias como el éster 28-0-Β-D-glucopiranósido del ácido rotúndico(pedunculósido)y el isómero 20(S) del éster 28-O-Β-D-glucopiranósido del ácido rotundioico.; From Ilex argentina Lillo leaves, a species reported as substitute or adulterant of the genuine erva-maté (Ilex paraguariensis A. St.-Hil.), two saponins and one triterpene have been isolated. By means of spectroscopic methods, this latter was identified as rotundic acid and the saponins as the 28-0-Β-D-glucopyranosylester of rotundic acid (pedunculoside)and the 20(S) isomer of 28-O-Β-D-glucopyranosylester of rotundioic acid.

2001-01-01T00:00:00Z Ilex argentina es una de las especies que ha sido mencionada como adulterante o sustituto de la yerba mate verdadera (l. paraguariensis). De las hojas fueron aisladas dos saponinas y un triterteno y sus estructuras químicas elucidadas a través de métodos espectroscópicos. El triterpeno fue identificado como el ácido rotúndico y las saponitias como el éster 28-0-Β-D-glucopiranósido del ácido rotúndico(pedunculósido)y el isómero 20(S) del éster 28-O-Β-D-glucopiranósido del ácido rotundioico. From Ilex argentina Lillo leaves, a species reported as substitute or adulterant of the genuine erva-maté (Ilex paraguariensis A. St.-Hil.), two saponins and one triterpene have been isolated. By means of spectroscopic methods, this latter was identified as rotundic acid and the saponins as the 28-0-Β-D-glucopyranosylester of rotundic acid (pedunculoside)and the 20(S) isomer of 28-O-Β-D-glucopyranosylester of rotundioic acid. López de Ruiz, Rosa Evelia Fusco, María del Rosario Sosa, Ángela Ruiz, Sohar Osvaldo http://sedici.unlp.edu.ar:80/handle/10915/6938 2013-10-17T12:02:29Z 2001-01-01T00:00:00Z

Articulo Isolation of flavonoids and anthraquinones of Amaranthus muricatus (Moquin) ex Hicken (Aniaranthaceae) Acta Farmacéutica Bonaerense; vol. 20, no. 1 Amaranthus muricatus (Moquin) Gillies ex Hicken (Amaranthaceae), de nombre común "yerba meona" "paiquillo" o "ataco", es usado en la medicina popular como diurético, laxante, emoliente y en cataplasma para hacer supurar las infecciones de la piel. Aplicando la técnica de extracción con solventes de polaridad creciente sobre la parte aérea, en el extracto obtenido con acetona se aislaron seis flavonoides (quercetina, ramnetina, isoramnetina, patuletina, penduletina y robinetina), todos ellos como geninas. Del extracto obtenido con metano1 se aislaron once flavonoides (3-O-galactósidoquercetina, quercetrina, rutina, 3-O-galactósidoisoramnetina, jaceína, 3-O-rutinósidoisoramnetina, robinina, centaurelna, patuletrina, 3-O-glucósidopatuletina y 3-O-rutinósidopatuletina), todos ellos al estado de glicósidos. Además, aplicando la técnica de la Farmacopea Británica para el estudio de drogas que contienen heterósidos antraquinónicos, se aislaron en la fracción hidrolizada en medio ácido cuatro geninas (dantrón, crisofanol, emodina y reina) mientras que en la fracción de hidrólisis oxidativa se aislaron dos geninas (dantrón y 1,6,8-trihidoxi-3-carboxiantraquinona.; Amaranthus muricatus, commoly known as "yerba meona", "paiquillo" o "ataco" is a species used in traditional medicine as diuretic, laxative, emollient and poultice to suppurate skin infection. The presence of flavonoids in the aerials parts of the plant was determined by increasing polarity solvent extraction; from the acetone extract were isolated six flavonoids (quercetine, rhamnetine, isorhamnetine, pendulecine and robinetine), al1 of them iii the forin of genines. From the methanol extract were isolated eleven flavonoids (3-0- galactosidequercetine, quercetrine, rutine, 3-O-galactosideisorhamnetine, jaceine, 3-O-rutinosideisorhamnetine, robinine, centaureine, patuletrine, 3-O-glucosidepatuletine and 3-O-nitinosidepatuletine), all of them as glycosides. Following the technique recommended by the British Pharmacopeia for the study of drugs containning anthraquinone heterosides, from the hydrolizable fraction in acid medium were isolated four genines (dantron, cliysophanol, emodine and rheine) and from the oxidative hydrolysis fraction were isolated two genines (dantron and 1,6,8-triliydroxy-3-carboxialitliaquinone).

2001-01-01T00:00:00Z Amaranthus muricatus (Moquin) Gillies ex Hicken (Amaranthaceae), de nombre común "yerba meona" "paiquillo" o "ataco", es usado en la medicina popular como diurético, laxante, emoliente y en cataplasma para hacer supurar las infecciones de la piel. Aplicando la técnica de extracción con solventes de polaridad creciente sobre la parte aérea, en el extracto obtenido con acetona se aislaron seis flavonoides (quercetina, ramnetina, isoramnetina, patuletina, penduletina y robinetina), todos ellos como geninas. Del extracto obtenido con metano1 se aislaron once flavonoides (3-O-galactósidoquercetina, quercetrina, rutina, 3-O-galactósidoisoramnetina, jaceína, 3-O-rutinósidoisoramnetina, robinina, centaurelna, patuletrina, 3-O-glucósidopatuletina y 3-O-rutinósidopatuletina), todos ellos al estado de glicósidos. Además, aplicando la técnica de la Farmacopea Británica para el estudio de drogas que contienen heterósidos antraquinónicos, se aislaron en la fracción hidrolizada en medio ácido cuatro geninas (dantrón, crisofanol, emodina y reina) mientras que en la fracción de hidrólisis oxidativa se aislaron dos geninas (dantrón y 1,6,8-trihidoxi-3-carboxiantraquinona. Amaranthus muricatus, commoly known as "yerba meona", "paiquillo" o "ataco" is a species used in traditional medicine as diuretic, laxative, emollient and poultice to suppurate skin infection. The presence of flavonoids in the aerials parts of the plant was determined by increasing polarity solvent extraction; from the acetone extract were isolated six flavonoids (quercetine, rhamnetine, isorhamnetine, pendulecine and robinetine), al1 of them iii the forin of genines. From the methanol extract were isolated eleven flavonoids (3-0- galactosidequercetine, quercetrine, rutine, 3-O-galactosideisorhamnetine, jaceine, 3-O-rutinosideisorhamnetine, robinine, centaureine, patuletrine, 3-O-glucosidepatuletine and 3-O-nitinosidepatuletine), all of them as glycosides. Following the technique recommended by the British Pharmacopeia for the study of drugs containning anthraquinone heterosides, from the hydrolizable fraction in acid medium were isolated four genines (dantron, cliysophanol, emodine and rheine) and from the oxidative hydrolysis fraction were isolated two genines (dantron and 1,6,8-triliydroxy-3-carboxialitliaquinone). Mamposo, Taimirys Pellón, Rolando http://sedici.unlp.edu.ar:80/handle/10915/6937 2013-10-17T12:02:29Z 2001-01-01T00:00:00Z

Articulo Use of microwave irradiation to obtain cinamic acid derivatives with piperidine as catalyst Acta Farmacéutica Bonaerense; vol. 20, no. 1 Fueron obtenidos diez derivados del ácido cinámico mediante la condensación del ácido malónico con diferentes benzaldehidos arilsustituidos en presencia de piperidina como catalizador, bajo irradiación de microondas. Como modelo se estudió la reacción del ácido 3,4-dimetoxicinámico. El rendimiento de los derivados aril sustituidos del ácido cinámico presenta un máximo para 7,5 milimoles de piperidina como catalizador cuando se lleva a cabo la reacción a 900 watts durante 30 segundos. Se realizó la elucidación estructural de todos los productos mediante la combinación de técnicas de IR, Análisis Elemental, RMN 1H y RMN 13C y Espectrometría de Masas.; Ten cinnamic acid derivatives were obtained by condensation of malonic acid with different aryl substituted benzaldeliydes in the presence of piperidine as catalyst under microwave irradiation. The reaction of 3,4- dimetlioxycinmamic acid was studied as a model. Maximum yield of the aryl substituted cinnamic acid derivatives was obtained by using 7.5 milimoles of piperidine when the reaction was carried out at 900 watts for 30 seconds. Structural elucidation of all the products was made by means of combined techniques: infrared spectroscopy, elemental analyses, 1H-NMR, 13C-NMR and mass spectra.

2001-01-01T00:00:00Z Fueron obtenidos diez derivados del ácido cinámico mediante la condensación del ácido malónico con diferentes benzaldehidos arilsustituidos en presencia de piperidina como catalizador, bajo irradiación de microondas. Como modelo se estudió la reacción del ácido 3,4-dimetoxicinámico. El rendimiento de los derivados aril sustituidos del ácido cinámico presenta un máximo para 7,5 milimoles de piperidina como catalizador cuando se lleva a cabo la reacción a 900 watts durante 30 segundos. Se realizó la elucidación estructural de todos los productos mediante la combinación de técnicas de IR, Análisis Elemental, RMN 1H y RMN 13C y Espectrometría de Masas. Ten cinnamic acid derivatives were obtained by condensation of malonic acid with different aryl substituted benzaldeliydes in the presence of piperidine as catalyst under microwave irradiation. The reaction of 3,4- dimetlioxycinmamic acid was studied as a model. Maximum yield of the aryl substituted cinnamic acid derivatives was obtained by using 7.5 milimoles of piperidine when the reaction was carried out at 900 watts for 30 seconds. Structural elucidation of all the products was made by means of combined techniques: infrared spectroscopy, elemental analyses, 1H-NMR, 13C-NMR and mass spectra.