http://sedici.unlp.edu.ar:80/handle/10915/125294 Fri, 13 Nov 2026 10:36:40 GMT 2026-11-13T10:36:40Z http://sedici.unlp.edu.ar:80/handle/10915/127204 Edicion de revista Physiological Mini Reviews (PMR); vol. 5, no. 6 Contiene el programa y los resúmenes de los trabajos presentados en la Reunión Anual de la Sociedad Argentina de Fisiología y el Congreso de la Sociedad Argentina de Investigación Clínica, realizados en 2011. Sun, 01 Jan 2012 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/127204 2012-01-01T00:00:00Z Contiene el programa y los resúmenes de los trabajos presentados en la Reunión Anual de la Sociedad Argentina de Fisiología y el Congreso de la Sociedad Argentina de Investigación Clínica, realizados en 2011. http://sedici.unlp.edu.ar:80/handle/10915/127203 Articulo Physiological Mini Reviews (PMR); vol. 5, no. 5 The first evidences indicating that angiotensin II (ANG II) was a peptide with action on the brain were shown in 1961 when it was found that the intraventricular injection of ANG II induces a centrally mediated pressor response (1). As a neuropeptide, ANG II belongs to the class of neuromodulators. The brain renin angiotensin system (RAS) exerts paracrine, autocrine and intracrine functions independently of circulating blood-borne ANG II which has a limited access to the brain by the blood-brain barrier (BBB) in the circumventricular organs (CVOs) (2). Brain-generated ANG II controls several physiological processes like stimulation of thirst, water intake and sodium appetite, acting as a neurotransmitter in neurons of brain areas such as the Subfornical organ (SFO) and Organum vasculosum of the lamina terminalis (OVLT). Generated angiotensins (ANGs) at the central nervous system (CNS) also stimulate endocrine secretions like argininevasopressin (AVP), oxytocin (OT), corticotrophin-releasing hormone (CRH) and adenocorticotrophin (ACTH secretion). Brain ANG II modulates the sympathetic autonomic functions and regulates blood pressure by increasing AVP and ACTH secretion and modulating the baroceptor reflex and the sympathetic output (3). During the last decade it has been established that, apart from its classical actions, ANG II exhibits other effects induced by direct action on its receptors or via local effects of its metabolites (4). Thereby, central actions of ANGs are not exclusively associated with their traditional roles. Indeed, several studies have shown that central ANGs are also involved in sexual behavior, stress, learning, and memory (5). Sat, 01 Jan 2011 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/127203 2011-01-01T00:00:00Z The first evidences indicating that angiotensin II (ANG II) was a peptide with action on the brain were shown in 1961 when it was found that the intraventricular injection of ANG II induces a centrally mediated pressor response (1). As a neuropeptide, ANG II belongs to the class of neuromodulators. The brain renin angiotensin system (RAS) exerts paracrine, autocrine and intracrine functions independently of circulating blood-borne ANG II which has a limited access to the brain by the blood-brain barrier (BBB) in the circumventricular organs (CVOs) (2). Brain-generated ANG II controls several physiological processes like stimulation of thirst, water intake and sodium appetite, acting as a neurotransmitter in neurons of brain areas such as the Subfornical organ (SFO) and Organum vasculosum of the lamina terminalis (OVLT). Generated angiotensins (ANGs) at the central nervous system (CNS) also stimulate endocrine secretions like argininevasopressin (AVP), oxytocin (OT), corticotrophin-releasing hormone (CRH) and adenocorticotrophin (ACTH secretion). Brain ANG II modulates the sympathetic autonomic functions and regulates blood pressure by increasing AVP and ACTH secretion and modulating the baroceptor reflex and the sympathetic output (3). During the last decade it has been established that, apart from its classical actions, ANG II exhibits other effects induced by direct action on its receptors or via local effects of its metabolites (4). Thereby, central actions of ANGs are not exclusively associated with their traditional roles. Indeed, several studies have shown that central ANGs are also involved in sexual behavior, stress, learning, and memory (5). http://sedici.unlp.edu.ar:80/handle/10915/127201 Edicion de revista Physiological Mini Reviews (PMR); vol. 5, no. 4 Contiene el programa y los resúmenes de los trabajos y conferencias presentados en la Reunión Anual de la Sociedad Argentina de Fisiología, el I Encuentro Nacional de Docentes de Fisiología y Física Biológica, realizados junto con el Congreso de la Sociedad Argentina de Investigación Clínica, el 17 de noviembre de 2010, en Mar del Plata (Argentina). Sat, 01 Jan 2011 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/127201 2011-01-01T00:00:00Z Contiene el programa y los resúmenes de los trabajos y conferencias presentados en la Reunión Anual de la Sociedad Argentina de Fisiología, el I Encuentro Nacional de Docentes de Fisiología y Física Biológica, realizados junto con el Congreso de la Sociedad Argentina de Investigación Clínica, el 17 de noviembre de 2010, en Mar del Plata (Argentina). http://sedici.unlp.edu.ar:80/handle/10915/127200 Articulo Physiological Mini Reviews (PMR); vol. 5, no. 2 This brief essay summarizes some personal thoughts on the NIH grant system. The thoughts arise in part from my experience as a dissenter from scientific orthodoxy, and in part from my experience as a member of several workshops convened to assess and fix problems with the NIH and NSF grant systems. Fri, 01 Jan 2010 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/127200 2010-01-01T00:00:00Z This brief essay summarizes some personal thoughts on the NIH grant system. The thoughts arise in part from my experience as a dissenter from scientific orthodoxy, and in part from my experience as a member of several workshops convened to assess and fix problems with the NIH and NSF grant systems. http://sedici.unlp.edu.ar:80/handle/10915/127199 Edicion de revista Physiological Mini Reviews (PMR); vol. 5, no. 1 Contiene el programa y los resúmenes de los trabajos presentados en el Congreso de la Sociedad Argentina de Fisiología celebrado el 15 y 16 de octubre de 2009. Fri, 01 Jan 2010 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/127199 2010-01-01T00:00:00Z Contiene el programa y los resúmenes de los trabajos presentados en el Congreso de la Sociedad Argentina de Fisiología celebrado el 15 y 16 de octubre de 2009. http://sedici.unlp.edu.ar:80/handle/10915/104650 Articulo Physiological Mini Reviews; vol. 5, no. 3 Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed. Mon, 01 Nov 2010 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/104650 2010-11-01T00:00:00Z Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.