http://sedici.unlp.edu.ar:80/handle/10915/126 Wed, 21 Oct 2026 10:09:47 GMT 2026-10-21T10:09:47Z http://sedici.unlp.edu.ar:80/handle/10915/6548 Articulo Plant and plant-derived compounds employed in prevention of the osteoporosis Acta Farmacéutica Bonaerense; vol. 21, no. 3 Actualmente la osteoporosis es reconocida como un problema de salud pública dado que esta enfermedad, que aumenta la fragilidad del hueso y por lo tanto el riesgo de fracturas, se asocia en todo el mundo a alta mortalidad y morbosidad y a altos costos médicos. El presente trabajo consiste en la revisión de la literatura con respecto a drogas vegetales, extractos semipuros y sustancias químicamente definidas, con actividad potencial en casos de osteoporosis. Esta revisión incluye 69 plantas, sus familias, partes utilizadas, tipos de extracto, modelos ensayados y la referencia correspondiente. Incluye también 46 sustancias aisladas de plantas superiores, clasificadas con respecto a su grupo químico. Se discuten algunos aspectos recientes de la investigación de productos naturales dirigida al tratamiento o prevención de la osteoporosis.; Osteoporosis is now widely recognized as a public health problem since this disease, which increases bone fragility and thereby the risk of fractures, is associated with high mortality, morbidity and medical expenses throughout the world. The present work is a literature review of crude plant extracts and chemically defined molecules employed in the osteoporosis. The review refers to 69 plants with their families, parts used, type of extract, model tested and references. It also includes 46 compounds isolated from higher plants and which are classified in appropriate chemical groups. Some aspects of recent research with natural products from plants directed to the treatment or prevention of osteoporosis are discussed. Tue, 01 Jan 2002 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/6548 2002-01-01T00:00:00Z Actualmente la osteoporosis es reconocida como un problema de salud pública dado que esta enfermedad, que aumenta la fragilidad del hueso y por lo tanto el riesgo de fracturas, se asocia en todo el mundo a alta mortalidad y morbosidad y a altos costos médicos. El presente trabajo consiste en la revisión de la literatura con respecto a drogas vegetales, extractos semipuros y sustancias químicamente definidas, con actividad potencial en casos de osteoporosis. Esta revisión incluye 69 plantas, sus familias, partes utilizadas, tipos de extracto, modelos ensayados y la referencia correspondiente. Incluye también 46 sustancias aisladas de plantas superiores, clasificadas con respecto a su grupo químico. Se discuten algunos aspectos recientes de la investigación de productos naturales dirigida al tratamiento o prevención de la osteoporosis. Osteoporosis is now widely recognized as a public health problem since this disease, which increases bone fragility and thereby the risk of fractures, is associated with high mortality, morbidity and medical expenses throughout the world. The present work is a literature review of crude plant extracts and chemically defined molecules employed in the osteoporosis. The review refers to 69 plants with their families, parts used, type of extract, model tested and references. It also includes 46 compounds isolated from higher plants and which are classified in appropriate chemical groups. Some aspects of recent research with natural products from plants directed to the treatment or prevention of osteoporosis are discussed. http://sedici.unlp.edu.ar:80/handle/10915/6547 Articulo Clopidogrel in the treatment of thrombotic events Acta Farmacéutica Bonaerense; vol. 21, no. 3 El clopidogrel es un nuevo antiagregante plaquetario utilizado en la prevención de complicaciones trombóticas y en la reducción de eventos isquémicos. Este fármaco actúa inhibiendo selectivamente la unión de adenosina difosfato (ADP) a sus receptores plaquetarios y la subsiguiente activación del complejo glicoproteico (Gp.) IIb/IIIa, produciéndose así la inhibición de la agregación plaquetaria. El clopidogrel también es capaz de inhibir la agregación plaquetaria producida por otros antagonistas. Estudios comparativos con drogas de igual actividad farmacológica demostraron que el clopidogrel tiene una eficacia similar a la ticlopidina y es más eficaz que la aspirina. Asímismo, el clopidogrel es la droga con mejor tolerabilidad y menor incidencia de efectos adversos y por lo tanto puede ser utilizada como una alternativa con muy buen perfil de seguridad.; Clopidrogel is a new antiplatelet agent that is used to prevent thrombotic complications and decrease the ischaemic events. This drug selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptors and the subsequent activation of the glycoprotein (Gp.) IIb/IIIa complex, producing the inhibition of the platelet aggregation. Comparative studies among drugs with the same pharmacological activity showed that clopidrogel has a similar efficacy to ticlopidine and is more effective than aspirine. Moreover, clopidrogel is the best tolerated drug and it has a lower incidence of adverse effects, and then it can be used as an alternative antiplatelet agent with an excellent safety profile. Tue, 01 Jan 2002 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/6547 2002-01-01T00:00:00Z El clopidogrel es un nuevo antiagregante plaquetario utilizado en la prevención de complicaciones trombóticas y en la reducción de eventos isquémicos. Este fármaco actúa inhibiendo selectivamente la unión de adenosina difosfato (ADP) a sus receptores plaquetarios y la subsiguiente activación del complejo glicoproteico (Gp.) IIb/IIIa, produciéndose así la inhibición de la agregación plaquetaria. El clopidogrel también es capaz de inhibir la agregación plaquetaria producida por otros antagonistas. Estudios comparativos con drogas de igual actividad farmacológica demostraron que el clopidogrel tiene una eficacia similar a la ticlopidina y es más eficaz que la aspirina. Asímismo, el clopidogrel es la droga con mejor tolerabilidad y menor incidencia de efectos adversos y por lo tanto puede ser utilizada como una alternativa con muy buen perfil de seguridad. Clopidrogel is a new antiplatelet agent that is used to prevent thrombotic complications and decrease the ischaemic events. This drug selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptors and the subsequent activation of the glycoprotein (Gp.) IIb/IIIa complex, producing the inhibition of the platelet aggregation. Comparative studies among drugs with the same pharmacological activity showed that clopidrogel has a similar efficacy to ticlopidine and is more effective than aspirine. Moreover, clopidrogel is the best tolerated drug and it has a lower incidence of adverse effects, and then it can be used as an alternative antiplatelet agent with an excellent safety profile. http://sedici.unlp.edu.ar:80/handle/10915/6546 Articulo Phytopharmaceutical drugs in primary care: disponibility and use Acta Farmacéutica Bonaerense; vol. 21, no. 3 Las plantas medicinales y sus preparaciones farmacéuticas tienen cada vez mayor aceptación por parte del personal de salud y de la población en general. Su utilización se concentra fundamentalmente en la Atención Primaria de Salud, donde contribuyen a resolver muchos problemas de salud. Teniendo estos aspectos en cuenta, se realizó un estudio descriptivo para valorar la disponibilidad de los fitofármacos en el área atendida por dos policlínicos de la ciudad de Santa Clara, así como el consumo de los mismos en el período comprendido de enero a octubre del año 2000, a partir de los datos de las farmacias pertenecientes a dichas instituciones. Además, se valoró el conocimiento del personal médico sobre este tema a través de encuestas aplicadas a 20 galenos de dichos policlínicos. Se encontró que la disponibilidad de fitofármacos en el período se mantuvo estable siendo mayor en el Policlínico Roberto Fleites. El consumo de fitofármacos fue aumentando progresivamente en el período analizado. Las plantas más empleadas fueron Aloe barbadensis, Eucalyptus globulus y Cucurbita moschata y los fitofármacos más utilizados fueron los expectorantes. Consideramos que el personal médico encuestado demostró conocimiento de la existencia y utilidad de las plantas y sus preparados.; Medicinal plants and their formulations have great acceptability into the health´s workers and people in general. The use of medicinal plant drugs is preferently developed in Primary Care of Health, where they contribute to resolve many problems. Taking this into account, a descriptive study was developed to evaluate the disponibility of these drugs in the area of two clinics in Santa Clara city and their use, in the period between January and October of 2000. The information was given in the pharmacies of these two clinics. The knowledge of the health workers was checked through the application of a formulary to 20 physicians of the clinics. It was found that the disponibility of phytopharmaceutical drugs was permanent, but it was bigger in Roberto Fleites clinic. The use of phytopharmaceutical drugs had a progressive increase during this period. Aloe barbadensis, Eucalyptus globulus and Cucurbita moschata were the plants with the greatest use, and phytopharmaceutical drugs with the bigger use were the expectorants. We consider that the health workers had good information about medicinal plants and their formulations. Tue, 01 Jan 2002 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/6546 2002-01-01T00:00:00Z Las plantas medicinales y sus preparaciones farmacéuticas tienen cada vez mayor aceptación por parte del personal de salud y de la población en general. Su utilización se concentra fundamentalmente en la Atención Primaria de Salud, donde contribuyen a resolver muchos problemas de salud. Teniendo estos aspectos en cuenta, se realizó un estudio descriptivo para valorar la disponibilidad de los fitofármacos en el área atendida por dos policlínicos de la ciudad de Santa Clara, así como el consumo de los mismos en el período comprendido de enero a octubre del año 2000, a partir de los datos de las farmacias pertenecientes a dichas instituciones. Además, se valoró el conocimiento del personal médico sobre este tema a través de encuestas aplicadas a 20 galenos de dichos policlínicos. Se encontró que la disponibilidad de fitofármacos en el período se mantuvo estable siendo mayor en el Policlínico Roberto Fleites. El consumo de fitofármacos fue aumentando progresivamente en el período analizado. Las plantas más empleadas fueron Aloe barbadensis, Eucalyptus globulus y Cucurbita moschata y los fitofármacos más utilizados fueron los expectorantes. Consideramos que el personal médico encuestado demostró conocimiento de la existencia y utilidad de las plantas y sus preparados. Medicinal plants and their formulations have great acceptability into the health´s workers and people in general. The use of medicinal plant drugs is preferently developed in Primary Care of Health, where they contribute to resolve many problems. Taking this into account, a descriptive study was developed to evaluate the disponibility of these drugs in the area of two clinics in Santa Clara city and their use, in the period between January and October of 2000. The information was given in the pharmacies of these two clinics. The knowledge of the health workers was checked through the application of a formulary to 20 physicians of the clinics. It was found that the disponibility of phytopharmaceutical drugs was permanent, but it was bigger in Roberto Fleites clinic. The use of phytopharmaceutical drugs had a progressive increase during this period. Aloe barbadensis, Eucalyptus globulus and Cucurbita moschata were the plants with the greatest use, and phytopharmaceutical drugs with the bigger use were the expectorants. We consider that the health workers had good information about medicinal plants and their formulations. http://sedici.unlp.edu.ar:80/handle/10915/6545 Articulo Ethnobotanical approach on the use of medicinal plants in Vila Cachoeira, Ilhéus, Bahia, Brasil Acta Farmacéutica Bonaerense; vol. 21, no. 3 Este trabalho foi conduzido na Comunidade de Vila Cachoeira, município de Ilhéus, Bahia, no período de setembro de 2000 à maio de 2001, tendo como objetivo analisar o resgate do conhecimento da comunidade sobre o uso de plantas medicinais. Foram entrevistados cinco informantes-chave, através de entrevista informal e questionários semiestruturados. As plantas indicadas foram coletadas, herborizadas, identificadas e incorporadas ao herbário da UESC. A análise final mostrou a ocorrência de 85 espécies de plantas medicinais, sendo 48% usadas na forma de chá, 19% como xarope, 16% na forma de banho e 9% administradas de outras formas. A parte mais utilizada das plantas foi a folha (64%) seguida da planta toda (13%), do fruto (8%), da casca (7%) e de outras partes (8%) como látex. Das plantas coletadas, 60,7% são herbáceas, 33,3% são arbóreas e 5,9% são arbustivas, em sua maioria cultivadas em quintais.; This research was developed in the community Vila Cachoeira, in the city of Ilhéus, Bahia, from September 2000 to May 2001, with the aim to analyze the remnant knowledge of that community about the use of medicinal plants. Information was achieved from five key informants, through informal interviews and half-structuralized questionnaires. The indicated plants were collected, identified, and incorporated into UESC herbarium. The final data analysis showed the occurrence of 85 species of medicinal plants, 48% being used as tea, 19% in the form of syrup, 16% in the form of bath and 9% in other forms. The most used parts of the plants were the leaf (64%), the whole plant (13%), the fruit (8%), the bark (7%) and other parts (8%) such as latex. Tue, 01 Jan 2002 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/6545 2002-01-01T00:00:00Z Este trabalho foi conduzido na Comunidade de Vila Cachoeira, município de Ilhéus, Bahia, no período de setembro de 2000 à maio de 2001, tendo como objetivo analisar o resgate do conhecimento da comunidade sobre o uso de plantas medicinais. Foram entrevistados cinco informantes-chave, através de entrevista informal e questionários semiestruturados. As plantas indicadas foram coletadas, herborizadas, identificadas e incorporadas ao herbário da UESC. A análise final mostrou a ocorrência de 85 espécies de plantas medicinais, sendo 48% usadas na forma de chá, 19% como xarope, 16% na forma de banho e 9% administradas de outras formas. A parte mais utilizada das plantas foi a folha (64%) seguida da planta toda (13%), do fruto (8%), da casca (7%) e de outras partes (8%) como látex. Das plantas coletadas, 60,7% são herbáceas, 33,3% são arbóreas e 5,9% são arbustivas, em sua maioria cultivadas em quintais. This research was developed in the community Vila Cachoeira, in the city of Ilhéus, Bahia, from September 2000 to May 2001, with the aim to analyze the remnant knowledge of that community about the use of medicinal plants. Information was achieved from five key informants, through informal interviews and half-structuralized questionnaires. The indicated plants were collected, identified, and incorporated into UESC herbarium. The final data analysis showed the occurrence of 85 species of medicinal plants, 48% being used as tea, 19% in the form of syrup, 16% in the form of bath and 9% in other forms. The most used parts of the plants were the leaf (64%), the whole plant (13%), the fruit (8%), the bark (7%) and other parts (8%) such as latex. http://sedici.unlp.edu.ar:80/handle/10915/6544 Articulo Ethyl carbamate content in wines produced and commercialized in Southern Brazil Acta Farmacéutica Bonaerense; vol. 21, no. 3 Aunque la producción de vinos en Brasil está bien establecida, hay escasa información acerca de las características y composición de estos productos. Los resultados presentados en esta oportunidad constituyen un informe inicial sobre la determinación química de carbamato de etilo en vinos brasileros.; Although the production of wines in Brazil is well established, there is little information on the characteristics and composition of these products. The results presented are an initial report on the chemical determination of ethyl carbamate in Brazilian wines. Tue, 01 Jan 2002 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/6544 2002-01-01T00:00:00Z Aunque la producción de vinos en Brasil está bien establecida, hay escasa información acerca de las características y composición de estos productos. Los resultados presentados en esta oportunidad constituyen un informe inicial sobre la determinación química de carbamato de etilo en vinos brasileros. Although the production of wines in Brazil is well established, there is little information on the characteristics and composition of these products. The results presented are an initial report on the chemical determination of ethyl carbamate in Brazilian wines. http://sedici.unlp.edu.ar:80/handle/10915/6543 Articulo Fertility in Balb/C mice supplemented with carbide waste in food Acta Farmacéutica Bonaerense; vol. 21, no. 3 El trabajo se realizó en la Unidad Toxicológica Experimental (UTEX) del Instituto Superior de Ciencias Médicas de Villa Clara, con el objetivo de valorar el posible efecto de la suplementación oral con Cieno de Acetileno sobre la fertilidad en ratones. Se utilizaron 32 ratones de la Línea Balb/C isogénicos y de categoría sanitaria convencional (24 hembras y 8 machos), de 20 ± 1 g de peso y 60 días de edad. Los animales se colocaron en cajas con cama de pacas de bagazo a razón de 6 hembras ó 4 machos por caja. La mitad de las hembras (12) y de los machos (4), fueron suplementados con Cieno de Acetileno al 5% en la dieta durante 60 días. El resto de los animales recibió como alimento el pienso convencional. Al día 61 de iniciado el experimento se procedió al apareamiento de los animales (3 hembras por macho) formando 4 grupos: Hembras y Machos suplementados ambos con Cieno; Hembras suplementadas con Cieno con Machos no suplementados; Machos suplementados con Cieno con Hembras no suplementadas; Hembras y Machos no suplementados (control). El apareamiento se mantuvo durante 21 días. En el grupo donde tanto Hembras como Machos recibieron el Cieno en la dieta, se obtuvieron mejores resultados en cuanto a Tiempo entre Apareamiento y Parto (24,6 dìas); % de Hembras Paridas (83%) y Promedio de Crías por Parto (5,0), en comparación con el grupo control (29,3 días; 66,7% de Paridas; 4,5 Crías por Parto, respectivamente). Se concluye que el Cieno de Acetileno, lejos de perjudicar, favorece los resultados de fertilidad en ratones cuando se administra al 5 % de la Dieta.; The present study was carried out at the Experimental Toxicology Unit of the Higher Institute of Medical Science of Villa Clara, to assess acetylene mud as oral supplement over fertility in laboratory mice. Thirty two Balb/C isogenic mice of conventional sanitary category were used (24 females and 8 males, 20 ± 1 g weight and 60 days old). Half of each sex was nurrished with conventional food. The other half was supplemented with acetylene mud (5%) in the same food during 60 days. On day 61th , mice were paired (three females per male) in four groups: females and males supplemented with acetylene mud; females nurrished with the mud but not males; males supplemented with mud but not females; females and males not supplemented with acetylene mud. The first group (both females and males treated with mud) had better results in paired-parturition interval, % of parturition, newborn/parturition index. We concluded that acetylene mud do not interfere fertility in mice, rather it increases reproductive behaviour in these animals. Tue, 01 Jan 2002 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/6543 2002-01-01T00:00:00Z El trabajo se realizó en la Unidad Toxicológica Experimental (UTEX) del Instituto Superior de Ciencias Médicas de Villa Clara, con el objetivo de valorar el posible efecto de la suplementación oral con Cieno de Acetileno sobre la fertilidad en ratones. Se utilizaron 32 ratones de la Línea Balb/C isogénicos y de categoría sanitaria convencional (24 hembras y 8 machos), de 20 ± 1 g de peso y 60 días de edad. Los animales se colocaron en cajas con cama de pacas de bagazo a razón de 6 hembras ó 4 machos por caja. La mitad de las hembras (12) y de los machos (4), fueron suplementados con Cieno de Acetileno al 5% en la dieta durante 60 días. El resto de los animales recibió como alimento el pienso convencional. Al día 61 de iniciado el experimento se procedió al apareamiento de los animales (3 hembras por macho) formando 4 grupos: Hembras y Machos suplementados ambos con Cieno; Hembras suplementadas con Cieno con Machos no suplementados; Machos suplementados con Cieno con Hembras no suplementadas; Hembras y Machos no suplementados (control). El apareamiento se mantuvo durante 21 días. En el grupo donde tanto Hembras como Machos recibieron el Cieno en la dieta, se obtuvieron mejores resultados en cuanto a Tiempo entre Apareamiento y Parto (24,6 dìas); % de Hembras Paridas (83%) y Promedio de Crías por Parto (5,0), en comparación con el grupo control (29,3 días; 66,7% de Paridas; 4,5 Crías por Parto, respectivamente). Se concluye que el Cieno de Acetileno, lejos de perjudicar, favorece los resultados de fertilidad en ratones cuando se administra al 5 % de la Dieta. The present study was carried out at the Experimental Toxicology Unit of the Higher Institute of Medical Science of Villa Clara, to assess acetylene mud as oral supplement over fertility in laboratory mice. Thirty two Balb/C isogenic mice of conventional sanitary category were used (24 females and 8 males, 20 ± 1 g weight and 60 days old). Half of each sex was nurrished with conventional food. The other half was supplemented with acetylene mud (5%) in the same food during 60 days. On day 61th , mice were paired (three females per male) in four groups: females and males supplemented with acetylene mud; females nurrished with the mud but not males; males supplemented with mud but not females; females and males not supplemented with acetylene mud. The first group (both females and males treated with mud) had better results in paired-parturition interval, % of parturition, newborn/parturition index. We concluded that acetylene mud do not interfere fertility in mice, rather it increases reproductive behaviour in these animals. http://sedici.unlp.edu.ar:80/handle/10915/6542 Articulo In vivo evaluation to the phototoxic potencial of cosmetics Acta Farmacéutica Bonaerense; vol. 21, no. 3 En el presente estudio se evaluó el efecto fototóxico de diferentes formulaciones cosméticas. Se utilizaron curieles albinos Hartley con peso corporal entre 300-500 g. Estos fueron sometidos a una dosis de 50,4 J/cm 2 de luz UVA durante un período de 2 h y se realizaron observaciones sobre la piel de los animales después de la irradiación, a las 24, 48 y 72 h. Como resultado se encontró que el modelo empleado permitió evaluar la el potencial fototóxico de las sustancias, las cuales no desarrollaron reacciones fototóxicas a nivel de la piel.; In our study the potential phototoxic effect of different cosmetic formulations have been tested. Albino Guinea pig Hartley was used in the experiences, with a body weight range from 300-500 g. The animals received a UVA dose of 50.4 J/cm 2 during a 2 h period. Skin reactions were observed after the irradiation, at 24, 48 and 72 h. The in vivo assay developed was an useful tool for evaluating phototoxic potential of the substances. The testing material did not show phototoxic reactions. Tue, 01 Jan 2002 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/6542 2002-01-01T00:00:00Z En el presente estudio se evaluó el efecto fototóxico de diferentes formulaciones cosméticas. Se utilizaron curieles albinos Hartley con peso corporal entre 300-500 g. Estos fueron sometidos a una dosis de 50,4 J/cm 2 de luz UVA durante un período de 2 h y se realizaron observaciones sobre la piel de los animales después de la irradiación, a las 24, 48 y 72 h. Como resultado se encontró que el modelo empleado permitió evaluar la el potencial fototóxico de las sustancias, las cuales no desarrollaron reacciones fototóxicas a nivel de la piel. In our study the potential phototoxic effect of different cosmetic formulations have been tested. Albino Guinea pig Hartley was used in the experiences, with a body weight range from 300-500 g. The animals received a UVA dose of 50.4 J/cm 2 during a 2 h period. Skin reactions were observed after the irradiation, at 24, 48 and 72 h. The in vivo assay developed was an useful tool for evaluating phototoxic potential of the substances. The testing material did not show phototoxic reactions. http://sedici.unlp.edu.ar:80/handle/10915/6541 Articulo Antispasmodic activity of leaf extracts of Mikania glomerata Sprengel (guaco) Acta Farmacéutica Bonaerense; vol. 21, no. 3 Dois métodos de extração, percolação e refluxo e dois líquidos extratores, etanol (96%, v/v) e mistura hidroetanólica (50%, v/v) foram utilizados para obter quatro soluções extrativas de folhas de Mikania glomerata visando a investigar a atividade antiespasmódica. As quatro soluções extrativas apresentaram antagonismo do tipo misto (competitivo e não- competitivo) observados nas curvas concentração efeito (CCE) produzidas pela acetilcolina (ACh) em jejuno de rato e histamina (Hist) em íleo isolado de porquinho da Índia. A solução extrativa etanólica obtida por percolação (SEEP) ou por refluxo (SEER) foram mais potentes do que as soluções extrativas hidroetanólicas (concentração inibitória 50%, CI 50 de 0,082 mg/mL e 0,103 mg/mL respectivamente para a Hist e ACh). As soluções extrativas hidroetanólicas obtidas por percolação (SEHEP) e refluxo (SEHER) foram menos potentes (CI 50 de 0,324 mg/mL e 3,594 mg/mL para a Hist e ACh). SEEP apresentou o maior teor de cumarina (2,065 mg/mL), no entanto, o efeito da atividade antiespasmódica observada nas preparações farmacêuticas não pode ser relacionado com o conteúdo de cumarina presente nas soluções extrativas, visto que a substância de referência não afetou as curvas CCE de Hist e ACh.; Two extraction methods, percolation and reflux and two extractive solutions, ethanolic (96%, v/v) and hidroethanolic (50%, v/v) were prepared in view to investigate the antispasmodic activity of Mikania glomerata extracts. The four extract behaves as a mixed antagonist (competitive and non-competitive) against concentration-response curves (CRC) elicited by acetylcholine (ACh) on rat jejunum and histamine (Hist) on guinea pig isolated ileum. Ethanolic extracts obtained by percolation (SEEP) or reflux (SEER) were more potent than hidroethanolic extracts (Inhibitory concentration 50%, CI 50 , of 0,082 mg/mL and 0,103 mg/mL respectively for Hist and ACh). Hidroethanolic extract obtained by percolation (SEHEP) followed by hidroethanolic extract obtained under reflux (SEHER) were the weakest (CI 50 of 0,324 and 3,594 mg/ml for histamine and ACh). The highest cumarine content (2,065 mg/mL) was obtained in SEEP. However, the antispasmodic effect observed in both pharmacological preparation could not be related to their cumarine content since the reference substance did not affect ACh or Hist CRC. Tue, 01 Jan 2002 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/6541 2002-01-01T00:00:00Z Dois métodos de extração, percolação e refluxo e dois líquidos extratores, etanol (96%, v/v) e mistura hidroetanólica (50%, v/v) foram utilizados para obter quatro soluções extrativas de folhas de Mikania glomerata visando a investigar a atividade antiespasmódica. As quatro soluções extrativas apresentaram antagonismo do tipo misto (competitivo e não- competitivo) observados nas curvas concentração efeito (CCE) produzidas pela acetilcolina (ACh) em jejuno de rato e histamina (Hist) em íleo isolado de porquinho da Índia. A solução extrativa etanólica obtida por percolação (SEEP) ou por refluxo (SEER) foram mais potentes do que as soluções extrativas hidroetanólicas (concentração inibitória 50%, CI 50 de 0,082 mg/mL e 0,103 mg/mL respectivamente para a Hist e ACh). As soluções extrativas hidroetanólicas obtidas por percolação (SEHEP) e refluxo (SEHER) foram menos potentes (CI 50 de 0,324 mg/mL e 3,594 mg/mL para a Hist e ACh). SEEP apresentou o maior teor de cumarina (2,065 mg/mL), no entanto, o efeito da atividade antiespasmódica observada nas preparações farmacêuticas não pode ser relacionado com o conteúdo de cumarina presente nas soluções extrativas, visto que a substância de referência não afetou as curvas CCE de Hist e ACh. Two extraction methods, percolation and reflux and two extractive solutions, ethanolic (96%, v/v) and hidroethanolic (50%, v/v) were prepared in view to investigate the antispasmodic activity of Mikania glomerata extracts. The four extract behaves as a mixed antagonist (competitive and non-competitive) against concentration-response curves (CRC) elicited by acetylcholine (ACh) on rat jejunum and histamine (Hist) on guinea pig isolated ileum. Ethanolic extracts obtained by percolation (SEEP) or reflux (SEER) were more potent than hidroethanolic extracts (Inhibitory concentration 50%, CI 50 , of 0,082 mg/mL and 0,103 mg/mL respectively for Hist and ACh). Hidroethanolic extract obtained by percolation (SEHEP) followed by hidroethanolic extract obtained under reflux (SEHER) were the weakest (CI 50 of 0,324 and 3,594 mg/ml for histamine and ACh). The highest cumarine content (2,065 mg/mL) was obtained in SEEP. However, the antispasmodic effect observed in both pharmacological preparation could not be related to their cumarine content since the reference substance did not affect ACh or Hist CRC. http://sedici.unlp.edu.ar:80/handle/10915/6540 Articulo Evaluation of the anticonvulsivant activity of plants from Northeastern Brazil Acta Farmacéutica Bonaerense; vol. 21, no. 3 No presente estudo foi realizada a avaliação em camundongos da possível atividade anticonvulsivante de 17 espécies vegetais do nordeste brasileiro usadas na medicina popular, através de 2 metodologias: O teste do pentilenotetrazol (PTZ) e o método do eletrochoque auricular. As espécies Bauhinia outimouta, Ximenia americana e Rauvolfia ligustrina apresentaram um aumento significativo na latência para o surgimento das convulsões clônicas induzidas por PTZ, efeito semelhante aos apresentados por drogas usadas clinicamente em quadros de epilepsia.; In the present study, the possible anticonvulsant effect of 17 plant species of northeastern Brazil, used in regional popular medicine, was investigated in mice, following two methodologies: the pentylenotetrazole (PTZ) test and the maximal electroshock. The species Bauhinia outimouta, Ximenia americana and Rauvolfia ligustrina caused a significant increase in latency for appearence seizures induced by PTZ, the same effect showed by drugs used in epilepsy. Tue, 01 Jan 2002 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/6540 2002-01-01T00:00:00Z No presente estudo foi realizada a avaliação em camundongos da possível atividade anticonvulsivante de 17 espécies vegetais do nordeste brasileiro usadas na medicina popular, através de 2 metodologias: O teste do pentilenotetrazol (PTZ) e o método do eletrochoque auricular. As espécies Bauhinia outimouta, Ximenia americana e Rauvolfia ligustrina apresentaram um aumento significativo na latência para o surgimento das convulsões clônicas induzidas por PTZ, efeito semelhante aos apresentados por drogas usadas clinicamente em quadros de epilepsia. In the present study, the possible anticonvulsant effect of 17 plant species of northeastern Brazil, used in regional popular medicine, was investigated in mice, following two methodologies: the pentylenotetrazole (PTZ) test and the maximal electroshock. The species Bauhinia outimouta, Ximenia americana and Rauvolfia ligustrina caused a significant increase in latency for appearence seizures induced by PTZ, the same effect showed by drugs used in epilepsy. http://sedici.unlp.edu.ar:80/handle/10915/6539 Articulo An application of the brine shrimp bioassay for general screening of Brazilian medicinal plants Acta Farmacéutica Bonaerense; vol. 21, no. 3 Extractos de once especies de la flora brasileña fueron estudiados para evaluar la actividad citotóxica por el test de Artemia salina. Las plantas seleccionadas fueron: Baccharis pseudotenuifolia, Baccharis ligustrina, Baccharis platypoda, Baccharis coridifolia, Polygala paniculata, Polygala sabulosa, Croton celtidifolius, Cyathea phalerata, Trichilia catigua, Eugenia uniflora y Schinus molle. Los resultados obtenidos para los extractos crudos de B. pseudotenuifolia, B. ligustrina, B. coridifolia, P. sabulosa, B. platypoda (CHCl 3 extract) y el extracto etanólico de C. celtidifolius (hojas) fueron promisorios. Estudios más específicos deben ser realizados sobre las plantas que mostraron actividad para este bioensayo para confirmar estas conclusiones.; Extracts of eleven species of Brazilian flora were subjected to a bioscreening study to detect cytotoxic activity by the brine shrimp lethality bioassay. The plants studied were: Baccharis pseudotenuifolia, Baccharis ligustrina, Baccharis platypoda, Baccharis coridifolia, Polygala paniculata, Polygala sabulosa, Croton celtidifolius, Cyathea phalerata, Trichilia catigua, Eugenia uniflora and Schinus molle. The results obtained for the crude extracts of B. pseudotenuifolia, B. ligustrina, B. coridifolia, P. sabulosa, and B. platypoda (CHCl 3 extract), and C. celtidifolius (ethanol leaf extract) were promising. These results suggest that more specific bioassays should be encouraged on those plant extracts in order to confirm these conclusions. Tue, 01 Jan 2002 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/6539 2002-01-01T00:00:00Z Extractos de once especies de la flora brasileña fueron estudiados para evaluar la actividad citotóxica por el test de Artemia salina. Las plantas seleccionadas fueron: Baccharis pseudotenuifolia, Baccharis ligustrina, Baccharis platypoda, Baccharis coridifolia, Polygala paniculata, Polygala sabulosa, Croton celtidifolius, Cyathea phalerata, Trichilia catigua, Eugenia uniflora y Schinus molle. Los resultados obtenidos para los extractos crudos de B. pseudotenuifolia, B. ligustrina, B. coridifolia, P. sabulosa, B. platypoda (CHCl 3 extract) y el extracto etanólico de C. celtidifolius (hojas) fueron promisorios. Estudios más específicos deben ser realizados sobre las plantas que mostraron actividad para este bioensayo para confirmar estas conclusiones. Extracts of eleven species of Brazilian flora were subjected to a bioscreening study to detect cytotoxic activity by the brine shrimp lethality bioassay. The plants studied were: Baccharis pseudotenuifolia, Baccharis ligustrina, Baccharis platypoda, Baccharis coridifolia, Polygala paniculata, Polygala sabulosa, Croton celtidifolius, Cyathea phalerata, Trichilia catigua, Eugenia uniflora and Schinus molle. The results obtained for the crude extracts of B. pseudotenuifolia, B. ligustrina, B. coridifolia, P. sabulosa, and B. platypoda (CHCl 3 extract), and C. celtidifolius (ethanol leaf extract) were promising. These results suggest that more specific bioassays should be encouraged on those plant extracts in order to confirm these conclusions. http://sedici.unlp.edu.ar:80/handle/10915/6538 Articulo Pharmacognostic analysis of the leaves of Alternanthera brasiliana (L.) Kuntze (Amaranthaceae) Acta Farmacéutica Bonaerense; vol. 21, no. 3 Alternanthera brasiliana, popularmente conhecida como penicilina, terramicina e perpétua-do-mato tem ações antiinflamatória, analgésica e antiviral comprovadas. Neste estudo foram analisadas morfo-anatomicamente as folhas desta espécie, afim de subsidiar a identificação da droga vegetal. As folhas são simples, oval-lanceoladas, peninérveas, opostas cruzadas, membranáceas, pilosas e com diversos padrões de coloração, do verde ao púrpura. A análise anatômica revelou folhas anfiestomáticas, com tricomas tectores ornamentados, mesofilo dorsiventral e padrão de venação eucampitódroma. Foram observadas alterações na disposição e no calibre dos feixes vasculares da nervura principal os quais são sempre do tipo colateral, com tecido esclerenquimático no pólo floemático.; Alternanthera brasiliana, known in Brazilian traditional medicine as penicilina, terramicina and perpétua-do-mato, has proved anti-inflammatory, analgesic and antiviral activities. The leaves were morpho-anatomically analyzed and the vegetal drug could be properly identified. It has simple, oval-lanceolate shaped, penninervate, oppositely crossed, membranaceous and pilose leaves, with different color standards, ranging from green to purple. Anatomy analysis showed amphistomatic leaves with ornamented non-glandular trichomes, dor-siventral mesophyll and eucamptodromous venation. Main vein showed changes in outlay and in the gauge of collateral vascular bundle, with sclerenchymatous tissue in the phloematic pole. Tue, 01 Jan 2002 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/6538 2002-01-01T00:00:00Z Alternanthera brasiliana, popularmente conhecida como penicilina, terramicina e perpétua-do-mato tem ações antiinflamatória, analgésica e antiviral comprovadas. Neste estudo foram analisadas morfo-anatomicamente as folhas desta espécie, afim de subsidiar a identificação da droga vegetal. As folhas são simples, oval-lanceoladas, peninérveas, opostas cruzadas, membranáceas, pilosas e com diversos padrões de coloração, do verde ao púrpura. A análise anatômica revelou folhas anfiestomáticas, com tricomas tectores ornamentados, mesofilo dorsiventral e padrão de venação eucampitódroma. Foram observadas alterações na disposição e no calibre dos feixes vasculares da nervura principal os quais são sempre do tipo colateral, com tecido esclerenquimático no pólo floemático. Alternanthera brasiliana, known in Brazilian traditional medicine as penicilina, terramicina and perpétua-do-mato, has proved anti-inflammatory, analgesic and antiviral activities. The leaves were morpho-anatomically analyzed and the vegetal drug could be properly identified. It has simple, oval-lanceolate shaped, penninervate, oppositely crossed, membranaceous and pilose leaves, with different color standards, ranging from green to purple. Anatomy analysis showed amphistomatic leaves with ornamented non-glandular trichomes, dor-siventral mesophyll and eucamptodromous venation. Main vein showed changes in outlay and in the gauge of collateral vascular bundle, with sclerenchymatous tissue in the phloematic pole. http://sedici.unlp.edu.ar:80/handle/10915/6537 Articulo Preliminary studies of anti-ulcerogenic effect of Aster squamatus leaves hydroalcoholic extract on various ulcer models in rats Acta Farmacéutica Bonaerense; vol. 21, no. 3 Se comprobó el efecto antiulcerogénico del extracto crudo hidroalcólico (70%) de las hojas de Aster squamatus (ECH) frente a úlceras inducidas por etanol, indometacina y estrés provocado por el frío. El ECH (500 y 1000mg/kg) redujo el índice de la lesión (IL) y el número de úlceras (NU) inducido por etanol. La dosis de 1000 mg/kg redujo el NU en el modelo de la indometacina y también redujo el IL e NU en el modelo provocado por estrés a frío. De acuerdo con los datos obtenidos, varios mecanismos de acción pueden estar involucrados en la protección gástrica. Subsiguientes estudios deben ser realizados para intentar poner en evidencia las substancias involucradas en el efecto anti-ulcerogénico del Aster squamatus.; The anti-ulcerogenic effect of crude hydroalcoholic extract (70%) of Aster squamatus leaves (CHE) was tested against ethanol-, indomethacin-, and cold stress- induced ulcers. The CHE (500 and 1000 mg/kg) reduced the lesion index (LI) and the number of ulcers (NU) in ethanol-induced ulcers. The dose of 1000 mg/kg reduced the NU in the model of the indomethacin, and also reduced the LI and NU in the stress model. According to the obtained data, several action mechanisms may be involved in the gastric protection. Subsequent studies should be made trying to evidence the substances involved in Aster squamatus anti-ulcerogenic effect. Tue, 01 Jan 2002 00:00:00 GMT http://sedici.unlp.edu.ar:80/handle/10915/6537 2002-01-01T00:00:00Z Se comprobó el efecto antiulcerogénico del extracto crudo hidroalcólico (70%) de las hojas de Aster squamatus (ECH) frente a úlceras inducidas por etanol, indometacina y estrés provocado por el frío. El ECH (500 y 1000mg/kg) redujo el índice de la lesión (IL) y el número de úlceras (NU) inducido por etanol. La dosis de 1000 mg/kg redujo el NU en el modelo de la indometacina y también redujo el IL e NU en el modelo provocado por estrés a frío. De acuerdo con los datos obtenidos, varios mecanismos de acción pueden estar involucrados en la protección gástrica. Subsiguientes estudios deben ser realizados para intentar poner en evidencia las substancias involucradas en el efecto anti-ulcerogénico del Aster squamatus. The anti-ulcerogenic effect of crude hydroalcoholic extract (70%) of Aster squamatus leaves (CHE) was tested against ethanol-, indomethacin-, and cold stress- induced ulcers. The CHE (500 and 1000 mg/kg) reduced the lesion index (LI) and the number of ulcers (NU) in ethanol-induced ulcers. The dose of 1000 mg/kg reduced the NU in the model of the indomethacin, and also reduced the LI and NU in the stress model. According to the obtained data, several action mechanisms may be involved in the gastric protection. Subsequent studies should be made trying to evidence the substances involved in Aster squamatus anti-ulcerogenic effect.