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dc.date.accessioned 2022-06-28T16:44:45Z
dc.date.available 2022-06-28T16:44:45Z
dc.date.issued 2008-05-01
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/138480
dc.description.abstract The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger in reverse mode (NCXrev), which triggers cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways. en
dc.format.extent 7096-7114 es
dc.language en es
dc.subject Cardiología es
dc.title Early signals after stretch leading to cardiac hypertrophy en
dc.type Articulo es
sedici.identifier.other https://doi.org/10.2741/3213 es
sedici.identifier.issn 2768-6698 es
sedici.title.subtitle Key role of NHE-1 en
sedici.creator.person Cingolani, Horacio Eugenio es
sedici.creator.person Pérez, Néstor Gustavo es
sedici.creator.person Aiello, Ernesto Alejandro es
sedici.creator.person Ennis, Irene Lucía es
sedici.creator.person Garciarena, Carolina Denis es
sedici.creator.person Villa Abrille, María Celeste es
sedici.creator.person Dulce, Raúl Ariel es
sedici.creator.person Caldiz, Claudia Irma es
sedici.creator.person Yeves, Alejandra del Milagro es
sedici.creator.person Correa, María Verónica es
sedici.creator.person Nolly, Mariela Beatriz es
sedici.creator.person Chiappe de Cingolani, Gladys Ethel es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Centro de Investigaciones Cardiovasculares es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Frontiers in Bioscience es
sedici.relation.journalVolumeAndIssue vol. 13, no. 18 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution 4.0 International (CC BY 4.0)