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dc.date.accessioned 2013-01-04T11:48:00Z
dc.date.available 2013-01-04T11:48:00Z
dc.date.issued 2012
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/25751
dc.description.abstract The present study was designed to investigate the protective effects of luteolin, a flavonoid, against acute immobilization-induced liver damage in mice. Mice were immobilized for a period of 6 h daily for three consecutive weeks. Luteolin (25 or 100 mg/kg, i.g.) was administered 30 min before subjecting the animals to restraint stress (RS). Our experiment showed that RS could induce liver damage, with an increase in glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) in the liver tissue. Furthermore, the changes of anti-oxidative capacity in liver tissue were also measured. The changes of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) and catalase activities (CAT) of stress group were significantly different from those in the control group. However, these changes in stress low and high-doses of luteolin modulation group were improved. These results demonstrated that luteolin has a protective effect against RS-induced liver damage through scavenging both free radicals activity and lipid peroxidation inhibitory effect. es
dc.language en es
dc.subject Liver damage es
dc.subject Luteolin es
dc.subject Oxidative stress es
dc.subject Restraint stress es
dc.title Protective effects of luteolin on restraint stress-induced liver damage in mice en
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_15.pdf es
sedici.identifier.issn 0326-2383
sedici.creator.person Liu, Yi es
sedici.creator.person Ling, Xin es
sedici.creator.person Gou, Lingshang es
sedici.creator.person Fu, Xiaobin es
sedici.creator.person Li, Sai es
sedici.creator.person Lan, Nuo es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 31, no. 7 es


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