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dc.date.accessioned 2013-01-04T12:06:52Z
dc.date.available 2013-01-04T12:06:52Z
dc.date.issued 2012
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/25752
dc.description.abstract In this study, the impacts of adrenalin on ovarian injury caused by ischemia reperfusion were investigated in rats. In addition, it’s been investigated whether there is a correlation between adrenergic receptors and oxidant/anti-oxidant and COX1/COX-2 levels. It’s been observed that the COX-2 level that is responsible for MDA and inflammatory reaction (which are the indicators of oxidative stress in ovarian tissue to which ischemia reperfusion was applied) increased and the COX-1 levels that are responsible for GSH (an endogenic anti-oxidant with protective impact) were depressed. Adrenalin has prevented an increase in MDA and COX-2 activity in the ovarian tissue, to which I/R was applied, and prevented a reduction in GSH and COX-1 activity. However, adrenalin failed to prevent an MDA increase in ovarian tissue, to which alpha-2 adrenergic receptor blocker yohimbine was given (I/R formed), and also failed to prevent a GSH and COX-1 decrease. Adrenalin also failed to inhibit the COX-2 activity increase in ovarian tissue, to which beta blocker was applied. As a result, stimulation of the alpha-2 adrenergic receptors in an ovarian tissue causes an anti-oxidant and protective effect, while stimulation of beta-2 adrenergic receptors causes an anti-inflammatory effect. It’s been thought that adrenalin protects the ovarian tissue against ischemia reperfusion by stimulating the alpha-2 and beta-2 adrenergic receptors. es
dc.language en es
dc.subject Adrenalin en
dc.subject COX1/COX-2 levels en
dc.subject Ischemia reperfusion en
dc.subject Ovarian injury en
dc.subject Rats en
dc.title Effects of adrenalin on ovarian injury formed by ischemia reperfusion in rats en
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_16.pdf es
sedici.identifier.issn 0326-2383
sedici.creator.person Yilmaz, Mehmet es
sedici.creator.person Ozgeris, Fatma B. es
sedici.creator.person Isaoglu, Unal es
sedici.creator.person Cetin, Nihal es
sedici.creator.person Turan, Mehmet I. es
sedici.creator.person Suleyman, Bahadir es
sedici.creator.person Gocer, Fatma es
sedici.creator.person Suleyman, Halis es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Articulo es
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 31, no. 7 es


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