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dc.date.accessioned | 2013-01-04T12:06:52Z | |
dc.date.available | 2013-01-04T12:06:52Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/25752 | |
dc.description.abstract | In this study, the impacts of adrenalin on ovarian injury caused by ischemia reperfusion were investigated in rats. In addition, it’s been investigated whether there is a correlation between adrenergic receptors and oxidant/anti-oxidant and COX1/COX-2 levels. It’s been observed that the COX-2 level that is responsible for MDA and inflammatory reaction (which are the indicators of oxidative stress in ovarian tissue to which ischemia reperfusion was applied) increased and the COX-1 levels that are responsible for GSH (an endogenic anti-oxidant with protective impact) were depressed. Adrenalin has prevented an increase in MDA and COX-2 activity in the ovarian tissue, to which I/R was applied, and prevented a reduction in GSH and COX-1 activity. However, adrenalin failed to prevent an MDA increase in ovarian tissue, to which alpha-2 adrenergic receptor blocker yohimbine was given (I/R formed), and also failed to prevent a GSH and COX-1 decrease. Adrenalin also failed to inhibit the COX-2 activity increase in ovarian tissue, to which beta blocker was applied. As a result, stimulation of the alpha-2 adrenergic receptors in an ovarian tissue causes an anti-oxidant and protective effect, while stimulation of beta-2 adrenergic receptors causes an anti-inflammatory effect. It’s been thought that adrenalin protects the ovarian tissue against ischemia reperfusion by stimulating the alpha-2 and beta-2 adrenergic receptors. | es |
dc.language | en | es |
dc.subject | Adrenalin | en |
dc.subject | COX1/COX-2 levels | en |
dc.subject | Ischemia reperfusion | en |
dc.subject | Ovarian injury | en |
dc.subject | Rats | en |
dc.title | Effects of adrenalin on ovarian injury formed by ischemia reperfusion in rats | en |
dc.type | Articulo | es |
sedici.identifier.uri | http://www.latamjpharm.org/resumenes/31/7/LAJOP_31_7_1_16.pdf | es |
sedici.identifier.issn | 0326-2383 | |
sedici.creator.person | Yilmaz, Mehmet | es |
sedici.creator.person | Ozgeris, Fatma B. | es |
sedici.creator.person | Isaoglu, Unal | es |
sedici.creator.person | Cetin, Nihal | es |
sedici.creator.person | Turan, Mehmet I. | es |
sedici.creator.person | Suleyman, Bahadir | es |
sedici.creator.person | Gocer, Fatma | es |
sedici.creator.person | Suleyman, Halis | es |
sedici.subject.materias | Farmacia | es |
sedici.description.fulltext | false | es |
mods.originInfo.place | Colegio de Farmacéuticos de la Provincia de Buenos Aires | es |
sedici.subtype | Articulo | es |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | Latin American Journal of Pharmacy | es |
sedici.relation.journalVolumeAndIssue | vol. 31, no. 7 | es |