Osmotic and activity coefficients of aqueous solutions of the anesthetic drugs lidocaine-HCl and procaine-HCl at 298.15 K

Torres, Daniel R.; Blanco, Luis H.; Vargas, Edgar F.; Martínez, Fleming

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Osmotic and activity coefficients of aqueous solutions of the anesthetic drugs lidocaine-HCl and procaine-HCl at 298.15 K

Authors: Torres, Daniel R. | Blanco, Luis H. | Vargas, Edgar F. | Martínez, Fleming

2010

Document type: Comunicacion

Abstract

Osmotic and activity coefficients were measured for aqueous solutions of Lidocaine-HCl and Procaine-HCl using the isopiestic method at 298.15 K. The results were fitted to the Pitzer equation and the parameters were calculated. A good correlation with the Pitzer model was found. The osmotic coefficients thus obtained were analyzed by comparing them with the Debye-Hückel limiting law. The results are discussed in terms of ion-solvent and ion-ion interactions.