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dc.date.accessioned 2011-03-11T14:31:00Z
dc.date.available 2011-03-11T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8122
dc.description.abstract The present study was designed to study the in vitro interaction of ketotifen fumarate and metformin hydrochloride in aqueous media at different pH values using Job’s continuous-variation analysis and Ardon’s spectrophotomeric measurement. Job’s analysis indicated the formation of 1:1 complex between ketotifen fumarate and metformin hydrochloride at the studied pH values. On the other hand, the values of stability constants (between negative values and 1), as calculated from Ardon’s plot, mean that the formation of complex due to interaction between the drugs is readily dissociable. Thus the findings of the study suggest that both drugs can be safely co-administered. However, further studies involving animal models are needed to ascertain the exact nature of interaction between them in vivo. es
dc.format.extent 189-192 es
dc.language en es
dc.subject Ardon's mehod; Job's method; ketotifen; metformin; stability constant es
dc.title In vitro study on interaction of ketotifen fumarate with metformin hydrochloride es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_2_6.pdf es
sedici.creator.person Sayeed, Mohammed Aktar es
sedici.creator.person Hasan, Raquibul es
sedici.creator.person Rana, Sohel es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001609 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 1 es


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