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dc.date.accessioned 2011-10-06T13:01:35Z
dc.date.available 2011-10-06T03:00:00Z
dc.date.issued 2011 es
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/8320
dc.description.abstract 4-Nerolidylcatechol (4-NRC) is the most abundant antioxidant product isolated from the roots of Pothomorphe umbellata (L) Miq. It displays important sunscreen protection and other pharmacological properties comprising analgesic, anti-inflammatory and antimicrobial activity. However, low water solubility and chemical instability has limited its use and analysis. Therefore, chemical modifications such as silylated derivatives and inclusion complexes have been proposed. Regarding antioxidants, electrochemical investigation techniques are important tools in comprehensive characterization of phenol molecules, showing higher selectivity than spectroscopic methods. In the present study, the 4-NRC and its derivatives are characterizated by voltammetric analysis in order to support physicochemical properties of 4-NRC inclusion-complex and catechol silylation products. It is observed that in both liquid- or solid-state the redox process of the 4-NRC is non-reversible and occurs in two stages, seen as two anodic peaks, respectively, at 0.75 and 1.12 V. The electrochemical techniques showed to be also a powerful tool to evaluate the efficiency of chemical modification on electroactive groups. es
dc.format.extent 440-1444 es
dc.language en es
dc.subject antioxidant; cyclodextrins; electrochemical, 4-nerolidylcatechol; silanized derivatives; voltammetry es
dc.subject Agentes Protectores es
dc.subject Solubilidad es
dc.subject Técnicas Electroquímicas es
dc.title Electroanalytical characterization of 4-nerolidylcatechol and its derivatives es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_2_5.pdf es
sedici.creator.person Leal, Ana Flávia V. B. es
sedici.creator.person Rezende, Kênnia R. es
sedici.creator.person Gil, Éric S. es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici2003.identifier ARG-FARM-ART-0000001807 es
sedici.relation.journalTitle Latin American Journal of Pharmacy es
sedici.relation.journalVolumeAndIssue vol. 30, no. 7 es


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