The escalation of antimicrobial resistance (AMR) poses an existential threat to global public health, underscoring a pressing need for novel strategies that not only effectively combat microbial pathogens but also uphold the principles of environmental sustainability. In this context, the Research Topic "Sustainable Synthesis for Obtaining Elements of Natural Origin with Antimicrobial Properties" converges on the promise of biogenic, green, and bioinspired materials that offer potent antimicrobial effects while minimizing ecological impact.