Synthesis and anti-inflammatory activity of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide

Shirote, Pramodkumar J.; Bhatia, Manish S.

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Synthesis and anti-inflammatory activity of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide

Authors: Shirote, Pramodkumar J. | Bhatia, Manish S.

2011

Document type: Comunicacion

Abstract

A novel compounds of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide (PJS1-PJS6) were synthesized by condensation of niflumic acid with aromatic amines using most reactive Lewis reagent: polyphosphoric acid trimethyl silyl ester (PPSE). These compounds were characterized by IR, 1H-NMR, HRMS-FAB and elemental analysis and evaluated for anti-inflammatory activity using carrageenin- induced rat paw oedema method. Compound PJS 5 showed significant activity exhibiting comparable reduction in edema.