Anti-inflammatory activity of leaves of Michelia champaca investigated on acute inflammation induced rats

Abstract

Natural products play a significant role in human health in relation to the prevention and treatment of inflammation conditions. Although not fully understood, several action mechanisms are proposed to explain in vivo inflammatory action. The aim of this study was to assay different extracts from leaves of Michelia champaca (Magnoliaceae) on carrageenan induced inflammation rat model. The results were analyzed by One Way Analysis of Variance (ANOVA). The ethanolic extract (200 mg/kg) was found to be highly significant (p < 0.0001) with maximum inhibition (60.99 %) at 3 h against to positive control group. The findings conclude that M. champaca leaves extract exhibits an anti-inflammatory activity in pro-inflammatory conditions.