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dc.date.accessioned 2020-07-17T18:53:54Z
dc.date.available 2020-07-17T18:53:54Z
dc.date.issued 2016-08
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/101039
dc.description.abstract There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and the cells were administered every 2 weeks afterward. The treatment did not induce any obvious changes in body growth or behavior and the rat showed the typical age changes for this strain, except that, unlike intact counterparts, the animal did not develop mammary tumors or pituitary gland hyperplasia. The more remarkable effect of the treatment was on life span, which was 44 months compared with an average of 36 months for intact laboratory rats. We conclude that despite the low N value, it is likely that the MSC treatment was responsible for the exceptionally long survival of the rat. The potential rewards of confirming the present findings warrant further studies involving higher N values. en
dc.format.extent 318-321 es
dc.language en es
dc.subject Mesenchymal stem cells es
dc.subject Female rats es
dc.subject Longevity es
dc.title A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age en
dc.type Articulo es
sedici.identifier.uri https://ri.conicet.gov.ar/11336/48858 es
sedici.identifier.other http://dx.doi.org/10.1089/rej.2015.1777 es
sedici.identifier.other hdl:11336/48858 es
sedici.identifier.issn 1549-1684 es
sedici.creator.person Mansilla, Eduardo es
sedici.creator.person Roque, Gustavo es
sedici.creator.person Sosa, Yolanda Elena es
sedici.creator.person Tarditti, Adrián es
sedici.creator.person Goya, Rodolfo Gustavo es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Instituto de Investigaciones Bioquímicas de La Plata es
sedici.subtype Preprint es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Rejuvenation Research es
sedici.relation.journalVolumeAndIssue vol. 19, no. 4 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)