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dc.date.accessioned 2020-08-07T18:40:54Z
dc.date.available 2020-08-07T18:40:54Z
dc.date.issued 2016-10
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/101711
dc.description.abstract Aims: To analyse the effect of Enterococcus faecalis CECT7121 on intestinalepithelial cells (IECs) and its effects on the mucosal immune response. Methods and Results: Enterococcus faecalis CECT7121 showed a high adhesioncapacity to completely and heterogeneously differentiated human intestinalepithelial cell line (Caco-2 cells). In addition, the contact of this bacteriumwith Caco-2 cells did not induce inflammatory chemokines (IL-8 and CCL-20). The presence of IgA⁺ and IL-6⁺ cells in the small intestine, as well as theproduction of inflammatory cytokines (TNFa, IL-6 and IL-12) in the gut, wasdetermined after intragastric inoculation of Ent. faecalis CECT7121 in BALB/cmice. The administration of Ent. faecalis CECT7121 increased the number ofIgA⁺ cells in the intestinal lamina propria without modifying the percentage ofIL-6⁺ cells. No differences were observed in the cytokines measured in theintestinal extracts between probiotic-treated and control mice. Conclusions: Enterococcus faecalis CECT7121 stimulates local mucosalimmunity and adheres to IECs without inducing inflammatory signals. Significance and Impact of the Study: Our results indicate that, apart from itsalready reported systemic immune activity, Ent. faecalis CECT7121 has amodulatory effect at a local level. en
dc.format.extent 1117-1129 es
dc.language en es
dc.subject adhesion to intestinal epithelial cells es
dc.subject Enterococcus faecalis CECT7121 es
dc.subject immunomodulation es
dc.subject mucosal immune response es
dc.subject probiotic activity es
dc.title Probiotic activity of Enterococcus faecalis CECT7121: effects on mucosal immunity and intestinal epithelial cells en
dc.type Articulo es
sedici.identifier.uri https://ri.conicet.gov.ar/11336/47117 es
sedici.identifier.uri https://onlinelibrary.wiley.com/doi/abs/10.1111/jam.13226 es
sedici.identifier.other https://dx.doi.org/10.1111/jam.13226 es
sedici.identifier.other hdl:11336/47117 es
sedici.identifier.issn 1364-5072 es
sedici.creator.person Castro, Marisa Silvia es
sedici.creator.person Molina, Matías Alejandro es
sedici.creator.person Azpiroz, María Belén es
sedici.creator.person Díaz, Ailén Magalí es
sedici.creator.person Ponzio, R. es
sedici.creator.person Sparo, Mónica Delfina es
sedici.creator.person Manghi, Marcela Alejandra es
sedici.creator.person Canellada, Andrea Mercedes es
sedici.subject.materias Medicina es
sedici.subject.materias Ciencias Exactas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Médicas es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Journal of Applied Microbiology es
sedici.relation.journalVolumeAndIssue vol. 121, no. 4 es

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