A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents

Abstract

A sulfonamide 1-tosyl-1-H-benzo(d)imidazol-2-amine (TBZA) and three new complexes of Co(II), Cu(II), and Zn(II) have been synthesized. The compounds have been characterized by elemental analyses, FTIR, ¹H, and ¹³C-NMR spectroscopy. The structure of the TBZA, and its Co(II) and Cu(II) complexes, was determined by X-ray diffraction methods. TBZA and its Co(II) complex crystallize in the triclinic P-1 space group, while the Cu(II) complex crystallizes in the monoclinic P2₁/c space group. Antifungal activity was screened against eight pathogenic yeasts: <i>Candida albicans</i> (DMic 972576), <i>Candida krusei</i> (DMic 951705), <i>Candida glabrata</i> (DMic 982882), <i>Candida tropicalis</i> (DMic 982884), <i>Candida dubliniensis</i> (DMic 93695), <i>Candida guilliermondii</i> (DMic 021150), <i>Cryptococcus neoformans</i> (ATCC 24067), and <i>Cryptococcus gattii</i> (ATCC MYA-4561). Results on the inhibition of various human (h) CAs, hCA I, II, IV, VII, IX, and XII, and pathogenic beta and gamma CAs are also reported.