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dc.date.accessioned 2020-10-14T16:01:58Z
dc.date.available 2020-10-14T16:01:58Z
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/106939
dc.description.abstract Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread and is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae, however, the emergence of striking resistant phenotypes, suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a leg-thickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared to susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype. en
dc.format El conjunto de datos se compone de un archivo Excel que contiene distintas mediciones sobre ejemplares de mosquitos Anopheles. es
dc.language es es
dc.subject insecticide resistance es
dc.subject cuticle alterations es
dc.subject legs es
dc.title Data from: Mosquitoes cloak their legs to resist insecticides en
dc.type Conjunto de datos es
sedici.identifier.uri https://rs.figshare.com/collections/Supplementary_material_from_Mosquitoes_cloak_their_legs_to_resist_insecticides_/4566284 es
sedici.identifier.other https://doi.org/10.6084/m9.figshare.c.4566284.v1 es
sedici.creator.person Balabanidou, Vasileia es
sedici.creator.person Kefi, Mary es
sedici.creator.person Aivaliotis, Michalis es
sedici.creator.person Koidou, Venetia es
sedici.creator.person Girotti, Juan Roberto es
sedici.creator.person Mijailovsky, Sergio Javier es
sedici.creator.person Juárez, Marta Patricia es
sedici.creator.person Papadogiorgaki, Eva es
sedici.creator.person Chalepakis, George es
sedici.creator.person Kampouraki, Anastasia es
sedici.creator.person Nikolaou, Christoforos es
sedici.creator.person Ranson, Hilary es
sedici.creator.person Vontas, John es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Instituto de Investigaciones Bioquímicas de La Plata es
sedici.subtype Conjunto de datos es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.relation.isRelatedWith http://sedici.unlp.edu.ar/handle/10915/106938 es
dc.date.created 2019
sedici.subject.ford Ciencias naturales es

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Creative Commons Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International (CC BY 4.0)