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dc.date.accessioned 2020-10-15T15:13:15Z
dc.date.available 2020-10-15T15:13:15Z
dc.date.issued 2014
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/107013
dc.description.abstract Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 ºC after 8 h incubation. en
dc.format.extent 103-110 es
dc.language en es
dc.subject Congo Red es
dc.subject Gel microspheres es
dc.subject Guar gum es
dc.subject Alginate es
dc.subject Coacervates es
dc.subject Infrared spectroscopy es
dc.title Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres en
dc.type Articulo es
sedici.identifier.other http://dx.doi.org/10.1016/j.reactfunctpolym.2014.06.006 es
sedici.identifier.issn 1381-5148 es
sedici.creator.person Bosio, Valeria Elizabeth es
sedici.creator.person Basu, Sreyasree es
sedici.creator.person Abdullha, Fraqooue es
sedici.creator.person Chacón Villalba, María Elizabeth es
sedici.creator.person Güida, Jorge Alberto es
sedici.creator.person Mukherjee, Arup es
sedici.creator.person Castro, Guillermo Raúl es
sedici.subject.materias Química es
sedici.description.fulltext true es
mods.originInfo.place Centro de Investigación y Desarrollo en Fermentaciones Industriales es
mods.originInfo.place Centro de Química Inorgánica es
mods.originInfo.place Facultad de Ingeniería es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Reactive & Functional Polymers es
sedici.relation.journalVolumeAndIssue vol. 82 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)