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dc.date.accessioned | 2020-10-22T12:28:24Z | |
dc.date.available | 2020-10-22T12:28:24Z | |
dc.date.issued | 2019 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/107504 | |
dc.description.abstract | Kaposi’s sarcoma (KS) is an AIDS-defining cancer caused by the KS-associated herpesvirus (KSHV). Unanswered questions regarding KS are its cellular ontology and the conditions conducive to viral oncogenesis. We identify PDGFRA(+)/SCA-1(+) bone marrow-derived mesenchymal stem cells (Pα(+)S MSCs) as KS spindle-cell progenitors and found that pro-angiogenic environmental conditions typical of KS are critical for KSHV sarcomagenesis. This is because growth in KS-like conditions generates a de-repressed KSHV epigenome allowing oncogenic KSHV gene expression in infected Pα(+)S MSCs. Furthermore, these growth conditions allow KSHV-infected Pα(+)S MSCs to overcome KSHV-driven oncogene-induced senescence and cell cycle arrest via a PDGFRA-signaling mechanism; thus identifying PDGFRA not only as a phenotypic determinant for KS-progenitors but also as a critical enabler for viral oncogenesis. | en |
dc.language | en | es |
dc.subject | Mesenchymal stem cells | es |
dc.subject | Gene expression | es |
dc.subject | Cancers and neoplasms | es |
dc.subject | Carcinogenesis | es |
dc.subject | Kaposi sarcoma | es |
dc.title | PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment | en |
dc.type | Articulo | es |
sedici.identifier.uri | http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6980685&blobtype=pdf | es |
sedici.identifier.other | pmid:31881074 | es |
sedici.identifier.other | pmcid:PMC6980685 | es |
sedici.identifier.other | https://doi.org/10.1371/journal.ppat.1008221 | es |
sedici.identifier.issn | 1553-7374 | es |
sedici.creator.person | Naipauer, Julian | es |
sedici.creator.person | Rosario, Santas | es |
sedici.creator.person | Gupta, Sachin | es |
sedici.creator.person | Premer, Courtney | es |
sedici.creator.person | Méndez-Solís, Omayra | es |
sedici.creator.person | Schlesinger, Mariana | es |
sedici.creator.person | Ponzinibbio, María Virginia | es |
sedici.creator.person | Jain, Vaibhav | es |
sedici.creator.person | Gay, Lauren | es |
sedici.creator.person | Renne, Rolf | es |
sedici.creator.person | Chan, Ho Lam | es |
sedici.creator.person | Morey, Lluis | es |
sedici.creator.person | Salyakina, Daria | es |
sedici.creator.person | Abba, Martín Carlos | es |
sedici.creator.person | Williams, Sion | es |
sedici.creator.person | Hare, Joshua M. | es |
sedici.creator.person | Goldschmidt-Clermont, Pascal J. | es |
sedici.creator.person | Mesri, Enrique A. | es |
sedici.subject.materias | Biología | es |
sedici.subject.materias | Ciencias Médicas | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Centro de Investigaciones Inmunológicas Básicas y Aplicadas | es |
sedici.subtype | Articulo | es |
sedici.rights.license | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | PLOS Pathogens | es |
sedici.relation.journalVolumeAndIssue | vol. 15, no. 12 | es |