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dc.date.accessioned 2020-10-27T13:47:55Z
dc.date.available 2020-10-27T13:47:55Z
dc.date.issued 2020
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/107778
dc.description.abstract Objective: To determine whether adalimumab administration before mechanical ventilation reduces ventilator- -induced lung injury (VILI). Methods: Eighteen rats randomized into 3 groups underwent mechanical ventilation for 3 hours with a fraction of inspired oxygen = 0.40% including a low tidal volume group (n = 6), where tidal volume = 8mL/kg and positive end-expiratory pressure = 5cmH2O; a high tidal volume group (n = 6), where tidal volume = 35mL/kg and positive end-expiratory pressure = 0; and a pretreated + high tidal volume group (n = 6) where adalimumab (100ug/kg) was administered intraperitoneally 24 hours before mechanical ventilation + tidal volume = 35mL/ kg and positive end-expiratory pressure = 0. ANOVA was used to compare histological damage (ATS 2010 Lung Injury Scoring System), pulmonary edema, lung compliance, arterial partial pressure of oxygen, and mean arterial pressure among the groups. Results: After 3 hours of ventilation, the mean histological lung injury score was higher in the high tidal volume group than in the low tidal volume group (0.030 versus 0.0051, respectively, p = 0.003). The high tidal volume group showed diminished lung compliance at 3 hours (p = 0.04) and hypoxemia (p = 0,018 versus control). Pretreated HVt group had an improved histological score, mainly due to a significant reduction in leukocyte infiltration (p = 0.003). Conclusion: Histological examination after 3 hours of injurious ventilation revealed ventilator-induced lung injury in the absence of measurable changes in lung mechanics or oxygenation; administering adalimumab before mechanical ventilation reduced lung edema and histological damage. en
dc.language en es
dc.subject Adalimumab/administration & dosage es
dc.subject Respiration, artificial es
dc.subject Respiratory failure es
dc.subject Ventilator-induced lung injury es
dc.title Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model en
dc.title.alternative Tratamento prévio com adalimumabe reduz lesão pulmonar induzida por ventilação mecânica em um modelo experimental pt
dc.type Articulo es
sedici.identifier.uri http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7206963&blobtype=pdf es
sedici.identifier.other pmid:32401991 es
sedici.identifier.other pmcid:PMC7206963 es
sedici.identifier.other https://doi.org/10.5935/0103-507x.20200010 es
sedici.identifier.issn 0103-507X es
sedici.creator.person Correger, Enrique es
sedici.creator.person Marcos, Josefina es
sedici.creator.person Laguens, Graciela es
sedici.creator.person Stringa, Pablo Luis es
sedici.creator.person Cardinal Fernández, Pablo es
sedici.creator.person Blanch, Lluis es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Médicas es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Revista Brasileira de Terapia Intensiva es
sedici.relation.journalVolumeAndIssue vol. 32, no. 1 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International (CC BY 4.0)