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dc.date.accessioned 2021-08-30T18:51:21Z
dc.date.available 2021-08-30T18:51:21Z
dc.date.issued 2015-02-13
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/123774
dc.description.abstract A small series of C-glycosides containing the phenol moiety was tested for the inhibition of the β-class carbonic anhydrases (βCAs, EC 4.2.1.1) from Brucella suis. Many compounds showed activities in the micromolar or submicromolar range and excellent selectivity for pathogen CAs over human isozymes. Glycosides incorporating the 3-hydroxyphenyl moiety showed the best inhibition profile, and therefore this functionality represents lead for the development of novel anti-infectives with a new mechanism of action. en
dc.format.extent 1017-1020 es
dc.language en es
dc.subject Antibacterial es
dc.subject Carbohydrate es
dc.subject Carbonic anhydrase es
dc.title Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety en
dc.type Articulo es
sedici.identifier.other pmid:25676329 es
sedici.identifier.other doi:10.3109/14756366.2014.986120 es
sedici.identifier.issn 1475-6374 es
sedici.identifier.issn 1475-6366 es
sedici.creator.person Riafrecha, Leonardo Ezequiel es
sedici.creator.person Vullo, Daniela es
sedici.creator.person Ouahrani-Bettache, Safia es
sedici.creator.person Köhler, Stephan es
sedici.creator.person Dumy, Pascal es
sedici.creator.person Winum, Jean-Yves es
sedici.creator.person Supuran, Claudiu T. es
sedici.creator.person Colinas, Pedro Alfonso es
sedici.subject.materias Química es
sedici.description.fulltext true es
mods.originInfo.place Laboratorio de Estudio de Compuestos Orgánicos es
sedici.subtype Comunicacion es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Journal of Enzyme Inhibition and Medicinal Chemistry es
sedici.relation.journalVolumeAndIssue vol. 30, no. 6 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)