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dc.date.accessioned 2021-09-13T15:18:29Z
dc.date.available 2021-09-13T15:18:29Z
dc.date.issued 2021-05
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/124686
dc.description.abstract The onset of labor involves the action of multiple factors and recent reports have postulated the endocannabinoid system as a new regulator of this process. Our objective was to study the role of anandamide, one of the main endocannabinoids, on the regulation of placental molecules that contribute to the onset of labor at term. Placental samples were obtained from patients with laboring vaginal deliveries and from non-laboring elective cesarean sections. Vaginal delivery placentas produced higher prostaglandins levels than cesarean section samples. Besides, no differences were observed in NOS basal activity between groups. Incubation of vaginal delivery placentas with anandamide increased prostaglandins concentration and decreased NOS activity. Antagonism of type-1cannabinoid receptor (CB1) did not alter the effect observed on NOS activity. Conversely, incubation of cesarean section placentas with anandamide reduced prostaglandins levels and enhanced NOS activity, the latter involving the participation of CB1. Furthermore, we observed a differential expression of the main components of the endocannabinoid system between placental samples, being the change in CB1 localization the most relevant finding. Our results suggest that anandamide acts as a modulator of the signals that regulate labor, exerting differential actions depending on CB1 localization in laboring or non-laboring term placentas. en
dc.language en es
dc.subject anandamide es
dc.subject prostaglandins es
dc.subject nitric oxide synthase es
dc.subject Placenta es
dc.subject labor es
dc.title Anandamide Exerts a Differential Effect on Human Placenta Before and After the Onset of Labor en
dc.type Articulo es
sedici.identifier.other pmid:34093231 es
sedici.identifier.other doi:10.3389/fphys.2021.667367 es
sedici.identifier.other pmcid:PMC8176211 es
sedici.identifier.issn 1664-042X es
sedici.creator.person Accialini, Paula es
sedici.creator.person Abán, Cyntia es
sedici.creator.person Etcheverry, Tomás es
sedici.creator.person Negri Malbrán, Mercedes es
sedici.creator.person Leguizamón, Gustavo es
sedici.creator.person Herlax, Vanesa Silvana es
sedici.creator.person Maté, Sabina María es
sedici.creator.person Farina, Mariana es
sedici.subject.materias Medicina es
sedici.subject.materias Bioquímica es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Médicas es
mods.originInfo.place Instituto de Investigaciones Bioquímicas de La Plata es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Frontiers in Physiology es
sedici.relation.journalVolumeAndIssue vol. 12 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International (CC BY 4.0)