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dc.date.accessioned 2021-09-24T15:50:31Z
dc.date.available 2021-09-24T15:50:31Z
dc.date.issued 2021-06
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/125575
dc.description.abstract Regulatory pathways involving non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNA), have gained great relevance due to their role in the control of gene expression modulation. Using RNA sequencing of KSHV Bac36 transfected mouse endothelial cells (mECK36) and tumors, we have analyzed the host and viral transcriptome to uncover the role lncRNA-miRNA-mRNA driven networks in KSHV tumorigenesis. The integration of the differentially expressed ncRNAs, with an exhaustive computational analysis of their experimentally supported targets, led us to dissect complex networks integrated by the cancer-related lncRNAs Malat1, Neat1, H19, Meg3, and their associated miRNA-target pairs. These networks would modulate pathways related to KSHV pathogenesis, such as viral carcinogenesis, p53 signaling, RNA surveillance, and cell cycle control. Finally, the ncRNA-mRNA analysis allowed us to develop signatures that can be used to an appropriate identification of druggable gene or networks defining relevant AIDS-KS therapeutic targets. en
dc.language en es
dc.subject Long non-coding es
dc.subject RNAs es
dc.subject microRNAs es
dc.subject KSHV es
dc.subject Network pathways es
dc.subject Druggable targets es
dc.title A Non-Coding RNA Network Involved in KSHV Tumorigenesis en
dc.type Articulo es
sedici.identifier.other https://doi.org/10.3389/fonc.2021.687629 es
sedici.identifier.issn 2234-943X es
sedici.creator.person Naipauer, Julián es
sedici.creator.person García Solá, Martín E. es
sedici.creator.person Salyakina, Daria es
sedici.creator.person Rosario, Santas es
sedici.creator.person Williams, Sion es
sedici.creator.person Coso, Omar es
sedici.creator.person Abba, Martín Carlos es
sedici.creator.person Mesri, Enrique A. es
sedici.creator.person Lacunza, Ezequiel es
sedici.description.note El material suplementario incluye: DataSheet_1_A Non-Coding RNA Network Involved in KSHV Tumorigenesis Supplementary Table 1 | DE lncRNAs in key biological comparisons detected by RNA-sequencing. Results were obtained after DeSeq2 analysis of: two KSHV (+) cells, two KSHV (−) cells, six KSHV (+) tumors, two KSHV (−) tumor cells and three KSHV (−) tumors. Supplementary Table 2 | Pathway analysis of the lncRNAs EVT. Supplementary Table 3 | Pathway analysis of the selected lncRNAs and their EVT genes DE in the corresponding comparisons. Supplementary Table 4 | DE miRNAs in key biological comparisons detected by small RNA-sequencing. Supplementary Table 5 | Pathway analysis of DE miRNAs and their EVT genes DE in the corresponding comparisons. Supplementary Table 6 | KSHV miRNAs analysis in KSHV (+) tumors and pathway analysis of their EVT. Supplementary Table 7 | lncRNA-miRNA-mRNA-Pathway networks. Supplementary Table 8 | Drugs associated with miRNA-gene pairs obtained from network analysis. es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Centro de Investigaciones Inmunológicas Básicas y Aplicadas es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Frontiers in Oncology es
sedici.relation.journalVolumeAndIssue vol. 11 es
sedici.relation.isRelatedWith http://sedici.unlp.edu.ar/handle/10915/125572 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution 4.0 International (CC BY 4.0)