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dc.date.accessioned 2021-09-27T14:28:33Z
dc.date.available 2021-09-27T14:28:33Z
dc.date.issued 2017-10
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/125645
dc.description.abstract Neutrophil extracellular traps (NETs) are web-like structures composed by a chromatin backbone, histones and antimicrobial proteins. NETs constitute yet another mechanism deployed by neutrophils to immobilise and kill microorganisms, thus contributing to the host innate immunity. Neutrophils cast NETs upon stimulation by a variety of stimuli, including bacteria, protozoa, fungi, viruses, their products and also host factors like chemokines, complement and activated platelets. NETs production or NETosis occurs as a result of activation of neutrophil PKC, Raf-MEK-ERK and NADPH oxydase signalling pathways. Driven mostly by peptidylarginine deiminase 4 (PAD4) citrullination of histones, the hallmark of NETosis is chromatin decondensation, rupture of nuclear membrane and release of nuclear and granular contents into the cytoplasm, prior their release into the extracellular space. NETs control propagation of pathogens by entrapping them within the lose chromatin web and kills them with the antimicrobial molecules –granule proteins and histones- present in high concentrations within the chromatin network. Despite contributing to host defence, aberrant NET formation may damage tissues and activate inflammatory cells, contributing to several pathologies, including sepsis, systemic inflammatory response syndrome, autoimmune diseases and thrombosis. This review presents an overview of our current knowledge of NETs physiology and their role in fighting and propagating disease. en
dc.format.extent 48-59 es
dc.language en es
dc.subject Neutrophil extracellular traps es
dc.subject Histones es
dc.subject Sepsis es
dc.title Neutrophil extracellular traps (NETS): role in disease en
dc.type Articulo es
sedici.identifier.uri https://pmr.safisiol.org.ar/archive/id/97 es
sedici.identifier.issn 1669-5410 es
sedici.creator.person Garciarena, Carolina Denis es
sedici.creator.person Kerrigan, Steve W. es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Sociedad Argentina de Fisiología es
mods.originInfo.place Facultad de Ciencias Médicas es
sedici.subtype Revision es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Physiological Mini Reviews es
sedici.relation.journalVolumeAndIssue vol. 10, no. 5 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International (CC BY 4.0)