Síndrome de boca ardiente

Abstract

El "Sindrome de la boca ardiente" comprende "Glosodynia o Glosalgia". Significa dolor de la lengua. "Glosopyrosis", sensacion de quemazon. Disestesia o parestesia es una experiencia de malestar dentro de la boca. "Glosodynia" es usado tambien cuando esta involucrada toda la cavidad bucal. ; Objetivo. Realizar una revision del tema y establecer la hipotesis que, este sindrome tendria un fondo psiconeuroinmunoendocrino relevante en el campo de las enfermedades autoinmunes. Promediando datos obtenidos, 80% de las mujeres sufren o han sufrido alguna vez de Glosodynia. Con un rango de 40 a 81 anos de edad, media de 60 anos, correspondiendo 2,9% al masculino y 15,7% al femenino. Localizacion: bordes de lengua 46%, dorso de lengua 46%, labios 50% y paladar 46%. La etiologia permanece desconocida. ; La revision esta centrada en describir varios aspectos clinicos, inmunologicos, endocrinologicos y neuronales involucrados en la genesis, enfocando principalmente la relacion con: la noradrenalina y las fibras amielinicas, los beta receptores, la histamina, la bradiquinina, las prostaglandinas, el eje hipotalamo-hipofisis-suprarrenal (HHS), el factor librador de corticotrofina (CRF) y la adrenocorticotropina (ACTH), las Interleuquinas 1, 6, 8, 10 y 12, el factor de necrosis tumoral alfa (TNFalfa), el factor de agregacion plaquetaria (PAF), los adenocorticoides (AGC), los mastocitos, la proteina A1 (AP-1), factores locales y sitemicos, la respuesta celular inmune y una base psicologica alterada. ; Conclusiones. Deberia realizarse un diagnostico a traves de la actividad del eje hipotalamo-pituitaria-adrenal del stress, investigando valores de la respuesta inmune celular. Bajo desordenes psicologicos serios, el paciente debe ser referido a un especialista apropiado.

The “Burning-Mouth-Syndrome” comprise “Glosodynia or Glosalgia” that means pain of the tongue. “Glosopyrosis”: burning sensation.” Dysesthesia or Paresthesia is a disconfortable experience inside the mouth. Glosodynia is used when the entire oral cavity is involved as well. The objective is to make a rewie about this syndrome and to postulate an hypothesis about etiology and diagnosis. Generally, about 80% of women suffer or once have suffered from Glosodynia. With a range of 40-81 years old, mean age 60 years old, correspond 2.9% male and 15.7% female. Llocalization: borders of tongue 46%, dorsum of tongue 46%, lips 50% and palate 46%. The etiology remains unknown. The hypothesis establish that this syndrome has a psychoneuroimmunoendocrinology background, relevant in the field of autoimmune diseases. The present review is centered in describing clinical, immumologic, endocrinologycal and neurologyc pathways involved in its genesis, and to focus its relationship with the role of noradrenalin and amyelinic fibers, the Beta receptors, histamine, bradiquinin, prostaglandins, HHS, CRF and ACTH, Il-1, IL-6,IL-8, IL-10,IL-2, TNFalpha, PAF, TGF-B, GHRH, PRL, glucocorticoids, mast cells, NK AP-1, local and systemic factors and an altered psychological base. Conclusions: Diagnosis could be made through the hypothalamic pituitary-adrenal axis activity by stress, investigating the cellular immune response. Under a serious underlying psychogenic disorder, patient must be referred to an appropriated specialist.