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dc.date.accessioned 2022-03-29T14:07:22Z
dc.date.available 2022-03-29T14:07:22Z
dc.date.issued 2007-09
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/133469
dc.description.abstract The oxovanadium(IV) complex of oxodiacetic acid (H₂oda) of stoichiometry [VO(oda)(H₂O)₂], which presents an unprecedented tridentate OOO coordination, was thoroughly characterized by infrared, Raman, electronic, and electron paramagnetic resonance spectroscopies. The biological activity of the complex on the cell proliferation and differentiation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but the cytotoxicity was stronger in the normal (MC3T3E1) than in the tumoral (UMR106) osteoblasts. The effect of the complex in cell differentiation was tested through the specific activity of alkaline phosphatase of the UMR106 cells because they expressed a high activity of this enzyme. What occurs with other vanadium compounds [VO(oda)(H₂O)₂] is an inhibitory agent of osteoblast differentiation. en
dc.format.extent 159-166 es
dc.language en es
dc.subject Oxovanadium(IV) es
dc.subject Oxodiacetic acid es
dc.subject Vibrational spectra es
dc.subject Electronic spectra es
dc.subject EPR spectra es
dc.subject Osteoblasts es
dc.subject Cells in culture es
dc.title Spectroscopic Characterization of a VO²⁺ Complex of Oxodiacetic Acid and its Bioactivity on Osteoblast-like Cells in Culture en
dc.type Articulo es
sedici.identifier.other doi:10.1007/s12011-007-0025-9 es
sedici.identifier.other pmid:17873358 es
sedici.identifier.issn 0163-4984 es
sedici.identifier.issn 1559-0720 es
sedici.creator.person Rivadeneira, Josefina es
sedici.creator.person Barrio, Daniel Alejandro es
sedici.creator.person Etcheverry, Susana Beatriz es
sedici.creator.person Baran, Enrique José es
sedici.subject.materias Ciencias Exactas es
sedici.subject.materias Química es
sedici.description.fulltext true es
mods.originInfo.place Facultad de Ciencias Exactas es
mods.originInfo.place Centro de Química Inorgánica es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Biological Trace Element Research es
sedici.relation.journalVolumeAndIssue vol. 118, no. 2 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution 4.0 International (CC BY 4.0)