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dc.date.accessioned | 2022-05-02T14:39:44Z | |
dc.date.available | 2022-05-02T14:39:44Z | |
dc.date.issued | 2008-01 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/135401 | |
dc.description.abstract | A comparative pharmacokinetic study was conducted to determine the order and the rate of absorption of triclabendazole (TCBZ) in cattle and sheep. A commercial suspension of TCBZ (Biofasiolex, Biogenesis S.A., Argentina) was administered at a dose rate of 10 mg/kg by the oral route to six Holstein female calves and six Corriedale female sheep. The plasma concentration profiles of the metabolites triclabendazole sulfoxide (TCBZ-SO) and triclabendazole sulfone (TCBZ-SO₂) were analysed by means of the non-compartmental method. The order of the absorption process of the active metabolite, TCBZ-SO, was determined by construction of curves of cumulative absorbed fraction of the drug by means of the Wagner-Nelson method. The appearance of TCBZ-SO in plasma of cattle and sheep resembles the entry of a constant quantity of drug into the organism per unit time. This is explained by the reservoir effect of the rumen, which acts as a biological slow-release system for TCBZ-SO and its precursor TCBZ to the posterior digestive tract where they are absorbed. The plasma concentration profiles of TCBZ-SO in both species were well described by a one-compartment open model with zero-order process of absorption and first-order process of elimination. The values of AUC0-∞ and Cmax of TCBZ-SO did not differ between species, while other kinetic parameters except for λz had higher values in calves than in sheep. In the case of TCBZ-SO₂, tmax was the only parameter that did not differ between species, while other kinetic parameters except for λz had higher values in calves than in sheep. | en |
dc.format.extent | 21-33 | es |
dc.language | en | es |
dc.subject | Absorption | es |
dc.subject | Cattle | es |
dc.subject | Pharmacokinetics | es |
dc.subject | Triclabendazole | es |
dc.subject | Sheep | es |
dc.title | Pharmacokinetic disposition of triclabendazole in cattle and sheep; discrimination of the order and the rate of the absorption process of its active metabolite triclabendazole sulfoxide | en |
dc.type | Articulo | es |
sedici.identifier.other | doi:10.1007/s11259-007-9000-3 | es |
sedici.identifier.other | pmid:17457687 | es |
sedici.identifier.issn | 0165-7380 | es |
sedici.identifier.issn | 1573-7446 | es |
sedici.creator.person | Mestorino, Olga Nora | es |
sedici.creator.person | Formentini, E. A. | es |
sedici.creator.person | Lucas, Mariana Florencia | es |
sedici.creator.person | Fernández, Cecilia | es |
sedici.creator.person | Modamio, P. | es |
sedici.creator.person | Mariño Hernández, E. | es |
sedici.creator.person | Errecalde, Jorge Oscar | es |
sedici.subject.materias | Veterinaria | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Facultad de Ciencias Veterinarias | es |
sedici.subtype | Articulo | es |
sedici.rights.license | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | Veterinary Research Communications | es |
sedici.relation.journalVolumeAndIssue | vol. 32, no. 1 | es |