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dc.date.accessioned 2022-05-20T12:55:10Z
dc.date.available 2022-05-20T12:55:10Z
dc.date.issued 2018
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/136602
dc.description.abstract Polymersomes are polymer-based vesicles that form upon hydration of amphiphilic block copolymers and display high stability and durability, due to their mechanical and physical properties. They have hydrophilic reservoirs as well as thick hydrophobic membranes; allowing to encapsulate both water-soluble bioactive agent and hydrophobic drugs. In this study, poly ethylene glycol (PEG3350 and PEG6000) were used as hydrophilic part and poly(vinyl benzoate) (PVBz) as hydrophobic block to synthesize amphiphilic triblock copolymers (PVBz-b-PEG-b-PVBz). Different proportions of hydrophilic/hydrophobic part were assayed in order to obtain polymersomes by solvent injection method. For the synthesis of the copolymers, the initial block of PEG was derived to obtain a macroinitiator through a xanthate functional group (PEGX3 or PEGX6) and the polymerization of vinyl benzoate was carried out through reversible addition-fragmentation chain transfer polymerization (RAFT). The structure of PEGX and copolymers was confirmed by Infrared, ¹H-NMR and UV-Vis spectrometry, while the average molecular weight (Mw) and polydispersity index (PI) were determined by size exclusion chromatography (SEC). The structures adopted by the copolymers in aqueous solution by self-assembly were investigated using transmission electron microscopy (TEM), dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS). Both techniques confirm that polymersomes were obtained for a fraction of hydrophilic block (f) ≈ 35 ± 10%, with a diameter of 38.3 ± 0.3 nm or 22.5 ± 0.7 nm, as determined by TEM and according to the M; w; of the precursor block copolymer. In addition, we analyzed the possible cytotoxicity in view of its potential application as biomedical nanocarrier. The results suggest that polymersomes seem not induce cytotoxicity during the periods of time tested. en
dc.language en es
dc.subject Triblock copolymer es
dc.subject Polymersomes es
dc.subject Selfassembly es
dc.subject Cytotoxicity es
dc.subject Nanomedicine es
dc.title Preparation, characterization, and in vitro activity evaluation of triblock copolymer-based polymersomes for drugs delivery en
dc.type Articulo es
sedici.identifier.other doi:10.1007/s11051-018-4169-7 es
sedici.identifier.issn 1388-0764 es
sedici.identifier.issn 1572-896X es
sedici.creator.person Besada, Lucas es
sedici.creator.person Peruzzo, Pablo José es
sedici.creator.person Cortizo, Ana María es
sedici.creator.person Cortizo, María Susana es
sedici.subject.materias Biología es
sedici.subject.materias Química es
sedici.description.fulltext true es
mods.originInfo.place Laboratorio de Investigación en Osteopatías y Metabolismo Mineral es
mods.originInfo.place Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Journal of Nanoparticle Research es
sedici.relation.journalVolumeAndIssue vol. 20, no. 3 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)