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dc.date.accessioned 2022-06-27T15:29:16Z
dc.date.available 2022-06-27T15:29:16Z
dc.date.issued 2006-02
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/138396
dc.description.abstract Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper, we report the nucleotide sequences of L RNA of Candid #1 and examine the relationship to its more virulent ancestors Junin virus XJ#44 and XJ 13 (prototype) and other closely and distantly related arenaviruses. Comparisons of the nucleotide and amino acid sequences of L and Z genes of Candid #1 and its progenitor strains revealed twelve point mutations in the L polypeptide that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype. In contrast, Z ORF was completely conserved among all strains. en
dc.format.extent 37-41 es
dc.language en es
dc.subject Arenaviridae es
dc.subject Junin es
dc.subject Attenuation es
dc.subject Molecular markers es
dc.subject L RNA es
dc.subject Genomic es
dc.title Genomic features of attenuated Junín virus vaccine strain candidate en
dc.type Articulo es
sedici.identifier.other doi:10.1007/s11262-005-5843-2 es
sedici.identifier.other pmid:16525733 es
sedici.identifier.issn 0920-8569 es
sedici.identifier.issn 1572-994X es
sedici.creator.person Goñi, Sandra Elizabeth es
sedici.creator.person Iserte, Javier Alonso es
sedici.creator.person Ambrosio, Ana Maria es
sedici.creator.person Romanowski, Víctor es
sedici.creator.person Ghiringhelli, Pablo Daniel es
sedici.creator.person Lozano, Mario Enrique es
sedici.subject.materias Biología es
sedici.description.fulltext true es
mods.originInfo.place Instituto de Biotecnología y Biología Molecular es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Virus Genes es
sedici.relation.journalVolumeAndIssue vol. 32, no. 1 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution 4.0 International (CC BY 4.0)