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dc.date.accessioned 2022-07-14T13:52:37Z
dc.date.available 2022-07-14T13:52:37Z
dc.date.issued 2008
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/139521
dc.description.abstract The aim of this work was to assess the possible correlation between oxidative damage and the development of cardiac hypertrophy in heart tissue from young (40-d-old) and older (4-, 11- and 19-month-old) spontaneously hypertensive rats (SHR) in comparison with age-matched Wistar (W) rats. To this end, levels of thiobarbituric acid reactive substances (TBARS), nitrotyrosine contents, NAD(P)H oxidase activity, superoxide production, and the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were determined. Compared to age-matched normotensive rats, SHR showed a significant increase in systolic blood pressure from 40 d of age and left ventricular hypertrophy (LVH) was significantly evident from 4 months of age. W rats (11- and 19-month-old) also showed an increase in LVH with aging. TBARS and nitrotyrosine levels were similar in young rats from both strains and were significantly increased with age in both strains, with the values in SHR being significantly higher than those in age-matched W rats. NAD(P)H activity was similar in young SHR and W rats, whereas it was higher in aged SHR compared with age-matched W rats. Compared to W rats, superoxide production was higher in aged SHR, and was abolished by NAD(P)H inhibition with apocynin. CAT activity was increased in the hearts of 4-month-old SHR compared to age-matched W rats and was decreased in the hearts of the oldest SHR compared to the oldest W rats. SOD and GPx activities decreased in both rat strains with aging. Moreover, an increase in collagen deposition with aging was evident in both rat strains. Taken together, these data showed that aged SHR exhibited higher cardiac hypertrophy and oxidative damage compared to W rats, indicating that the two undesirable effects are associated. That is, oxidative stress appears to be a cause and/or consequence of hypertrophy development in this animal model. en
dc.format.extent 1465-1476 es
dc.language en es
dc.subject antioxidant enzymes es
dc.subject hypertrophy es
dc.subject thiobarbituric acid reactive substances es
dc.subject nitrotyrosine es
dc.subject superoxide production es
dc.title Is Cardiac Hypertrophy in Spontaneously Hypertensive Rats the Cause or the Consequence of Oxidative Stress? en
dc.type Articulo es
sedici.identifier.other doi:10.1291/hypres.31.1465 es
sedici.identifier.other pmid:18957818 es
sedici.identifier.issn 0916-9636 es
sedici.identifier.issn 1348-4214 es
sedici.creator.person Álvarez, María Cecilia es
sedici.creator.person Caldiz, Claudia Irma es
sedici.creator.person Fantinelli, Juliana Catalina es
sedici.creator.person Garciarena, Carolina Denis es
sedici.creator.person Console-Avegliano, Gloria Miriam es
sedici.creator.person Chiappe de Cingolani, Gladys Ethel es
sedici.creator.person Mosca, Susana María es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Centro de Investigaciones Cardiovasculares es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Hypertension Research es
sedici.relation.journalVolumeAndIssue vol. 31, no. 7 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)