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dc.date.accessioned | 2022-11-04T18:17:00Z | |
dc.date.available | 2022-11-04T18:17:00Z | |
dc.date.issued | 1979-09-02 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/145237 | |
dc.description.abstract | The ultrastructural changes in pancreatic β cells were studied following glucose-induced insulin secretion in vitro, at two different extracellular pH (7.4 and 7.8). The pancreata perfused at pH 7.4 exhibited a biphasic insulin response to glucose challenge together with signs of increased emiocytotic activity and numerous microtubules in the β cells. Conversely, the pancreata perfused at pH 7.8 showed a significant decrease in insulin secretion, and their β cells revealed scarce emiocytotic images and a marked increase of intracellular granulolysis. These results represent the ultrastructural correlate of the reduced insulin secretion produced by metabolic alkalosis in the perfused rat pancreas. | en |
dc.format.extent | 159-163 | es |
dc.language | en | es |
dc.subject | Insulin secretion | es |
dc.subject | Electron microscopy | es |
dc.subject | Acid-base changes | es |
dc.subject | Pancreas perfusion | es |
dc.title | Ultrastructural responses of pancreatic β cells to metabolic alkalosis | en |
dc.type | Articulo | es |
sedici.identifier.other | doi:10.1007/bf00238055 | es |
sedici.identifier.other | pmid:43194 | es |
sedici.identifier.issn | 0302-766X | es |
sedici.identifier.issn | 1432-0878 | es |
sedici.creator.person | Gómez Dumm, César Leandro Alberto | es |
sedici.creator.person | Rebolledo, Oscar Remigio | es |
sedici.creator.person | Gagliardino, Juan José | es |
sedici.subject.materias | Biología | es |
sedici.subject.materias | Ciencias Médicas | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Centro de Endocrinología Experimental y Aplicada | es |
sedici.subtype | Articulo | es |
sedici.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | Cell and Tissue Research | es |
sedici.relation.journalVolumeAndIssue | vol. 201, no. 1 | es |