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dc.date.accessioned | 2022-11-16T17:18:46Z | |
dc.date.available | 2022-11-16T17:18:46Z | |
dc.date.issued | 2020-09 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/145951 | |
dc.description.abstract | Peripheral blood mononuclear cells (PBMC) from patients with ocular toxoplasmosis were challenged with total antigens from Toxoplasma gondii lysate (TATL) in a cytokine release assay (CRA), run during the inactive period of the disease. Increased interferon gamma (IFN-γ) levels were detected after PBMC stimulation with either ME49 reference strain (P = 0.0015) or local TgCkAr-11-9 isolate (P = 0.0012), as compared with those recorded under basal conditions. TATL from TgCkAr11-9 isolate induced a higher release of IFN-γ than ME49 strain in CRA from all tested patients (P = 0.02). The median value of IFN-γ release on TgCkAr-11-9 stimulation (26.03 pg/mL) allowed the classification of patients into high- or low-/non-IFN-γ releasers. Clinical correlations were established with both groups. The results obtained in this study suggest the need to include local strains when performing CRA with TATL. | en |
dc.format.extent | 2239-2243 | es |
dc.language | en | es |
dc.subject | Ocular toxoplasmosis | es |
dc.subject | Cytokine release | es |
dc.title | Interferon-γ and IL-10 release assay for patients with ocular toxoplasmosis | en |
dc.type | Articulo | es |
sedici.identifier.other | doi:10.4269/ajtmh.20-0124 | es |
sedici.identifier.other | pmcid:PMC7695064 | es |
sedici.identifier.other | pmid:32901605 | es |
sedici.identifier.issn | 1476-1645 | es |
sedici.identifier.issn | 0002-9637 | es |
sedici.creator.person | Rudzinski, Marcelo | es |
sedici.creator.person | Pardini, Lais Luján | es |
sedici.creator.person | Bernstein, Mariana | es |
sedici.creator.person | Moré, Gastón Andrés | es |
sedici.creator.person | Khoury, Marina | es |
sedici.creator.person | Duarte, Silvana Carolina | es |
sedici.creator.person | Argüelles, Carina Francisca | es |
sedici.creator.person | Reina, Silvia | es |
sedici.creator.person | Oubiña, Jose Raul | es |
sedici.subject.materias | Biología | es |
sedici.subject.materias | Ciencias Médicas | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Facultad de Ciencias Veterinarias | es |
sedici.subtype | Articulo | es |
sedici.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | The American Journal of Tropical Medicine and Hygiene | es |
sedici.relation.journalVolumeAndIssue | vol. 103, no. 6 | es |