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dc.date.accessioned | 2022-11-30T13:22:38Z | |
dc.date.available | 2022-11-30T13:22:38Z | |
dc.date.issued | 1998 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/146619 | |
dc.description.abstract | The aim of the present study was to determine the role of the endogenous sex steroid environment in the hypothalamo-corticotrope (HC) function in both sham-operated (SHAM) and bilaterally adrenalectomized (ADX) rats. For this purpose adult rats of both sexes were used 3 and 6 weeks after either SHAM or ADX. The results indicate that: a) in SHAM animals, basal plasma ACTH levels were significantly higher in females than in males, and this sexual dimorphism was overridden by ADX, regardless of the time post-surgery; b) although basal anterior pituitary (AP) ACTH content was similar in SHAM animals of both sexes, 3- and 6-week ADX induced higher AP ACTH in males than in females; c) at 3- and 6-weeks, ADX rats of hoth sexes had an AVP: CRH ratio (r), in the median eminence (ME) and medial basal hypothalamus (MBH), increased several fold over the respective SHAM-value and, although no sexual dimorphism was found at week 3 post-ADX, by 6-weeks post ADX, these ratios were significantly higher in both brain tissues of females than in those of males; and d) the in vitro ME CRH and AVP output in response to high potassium concentrations (hK+; 28 and 56 mmol/l), was concentration-related, regardless of sex and surgery, and was characterized by enhanced secretion of neuropeptides by MEs from ADX in comparison to SHAM rats of both sexes, and a sexual dimorphism was found in this parameter, consisting in general, in greater neuropeptide output from tissues of female than of male animals. Our results indicate that: 1) there is a gender-dependent characteristic of the HC axis function in glucocorticoid-replete rats and 2) the absence of the glucocorticoid negative feedback mechanism is responsible for either the expression or for the override of the sexual dimorphism in different parameters, a phenomenon which dependent on the time elapsed after ADX. | en |
dc.format.extent | 737-743 | es |
dc.language | en | es |
dc.title | Gender-dependent characteristics of the hypothalamo-corticotrope axis function in glucocorticoid-replete and glucocorticoid-depleted rats | en |
dc.type | Articulo | es |
sedici.identifier.other | doi:10.1007/bf03348038 | es |
sedici.identifier.other | pmid:9972672 | es |
sedici.identifier.issn | 0391-4097 | es |
sedici.identifier.issn | 1720-8386 | es |
sedici.creator.person | Chisari, Andrea Nancy | es |
sedici.creator.person | Perone, M. J. | es |
sedici.creator.person | Giovambattista, Andrés | es |
sedici.creator.person | Spinedi, Eduardo Julio | es |
sedici.subject.materias | Ciencias Médicas | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Instituto Multidisciplinario de Biología Celular | es |
mods.originInfo.place | Facultad de Ciencias Exactas | es |
sedici.subtype | Articulo | es |
sedici.rights.license | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | Journal of Endocrinological Investigation | es |
sedici.relation.journalVolumeAndIssue | vol. 21, no. 11 | es |