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dc.date.accessioned 2022-12-07T12:45:50Z
dc.date.available 2022-12-07T12:45:50Z
dc.date.issued 2005-09
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/146967
dc.description.abstract Two polypeptide hormones are produced, stored and secreted in a regulated manner by cardiac muscle cells (cardiocytes) of the atria of the heart of mammals. These are atrial natriuretic factor (ANF)1-3 and brain natriuretic peptide (BNP).4 They form part of a family of hormones referred to as natriuretic peptides (NP). A third member: CNP, is not natriuretic and is not produced by cardiocytes. Both ANF and BNP are co-stored in atrial cardiocytes in storage granules referred to as specific atrial granules. Some confusion has recently developed in the clinical literature as to the precise cell type where this secretory function resides, as well as to the peptide storage form and the location of the secretory function, which, of late, is often quoted as being the atria for ANF and the ventricular muscle for BNP. By Northern blot analysis, immunocytochemistry, in situ hybridization, radioimmunoassay and oligonucleotide array, ANF and BNP are far more abundant in the atria than the ventricles. In fact, the level of expression of NP in the normal ventricles is negligible compared to that of the atria. en
dc.language en es
dc.subject Atrial natriuretic factor es
dc.subject Brain natriuretic peptide es
dc.subject Ventricles es
dc.subject Atria es
dc.subject Fisiología es
dc.title The endocrine heart: from the bench to the bedside and back to the bench en
dc.type Articulo es
sedici.identifier.uri https://pmr.safisiol.org.ar/wp-content/uploads/2022/02/vol1_n2_september.pdf es
sedici.identifier.issn 1669-5410 es
sedici.creator.person de Bold, Adolfo J. es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Sociedad Argentina de Fisiología es
sedici.subtype Revision es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Physiological Mini Reviews (PMR) es
sedici.relation.journalVolumeAndIssue vol. 1, no. 2 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution 4.0 International (CC BY 4.0)