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dc.date.accessioned 2023-02-09T16:57:03Z
dc.date.available 2023-02-09T16:57:03Z
dc.date.issued 2008-07
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/148577
dc.description.abstract Enhanced proliferation, aberrant differentiation, and impaired ability to die are the prime reasons for abnormal tissue growth, which can eventually turn into uncontrolled expansion and invasion, characteristic of cancer. Ion channels contribute to virtually all basic cellular processes, including those for maintaining tissue homeostasis as proliferation, differentiation, and apoptosis (1). Changes in cell volume are crucial events during both cell proliferation and apoptosis and thus on tumor development and growth (2). Cell proliferation depends on an increased cell volume and cell shrinkage is a characteristic of apoptosis. Potassium, calcium, chloride channels and others are abnormally expressed in the membrane of tumor cells. By the regulation of membrane voltage, cell volume, Ca2+ signaling, cytosolic pH and cell cycle, they can adjust the cell proliferation and apoptosis. The specific blockade of ion channels may not only allow the dissection of the channel role in distinct physiologic processes, but because of the implication of them in tumor development, it may also offer an opportunity for the treatment of cancer. However, many ion channels are structurally similar to one another, and it has been notoriously difficult to obtain specific blockers for any given channel, thus it is essential to generate more potent and specific inhibitors of ion channels before using them in human therapeutics. en
dc.format.extent 41-48 es
dc.language en es
dc.subject Ión es
dc.subject Fisiología es
dc.subject Células es
dc.subject Leucemia es
dc.title Ion channels in k562 human leukemic cells and the relation with the multidrug resistance en
dc.type Articulo es
sedici.identifier.uri https://pmr.safisiol.org.ar/issue/ion-channels-in-k562-human-leukemic-cells-and-the-relation-with-the-multidrug-resistance/ es
sedici.identifier.issn 1669-5410 es
sedici.creator.person Assef, Yanina es
sedici.creator.person Kotsias, Basilio A. es
sedici.subject.materias Ciencias Médicas es
sedici.description.fulltext true es
mods.originInfo.place Sociedad Argentina de Fisiología es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Physiological Mini Reviews (PMR) es
sedici.relation.journalVolumeAndIssue vol. 3, no. 6 es


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Creative Commons Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International (CC BY 4.0)