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dc.date.accessioned 2023-05-10T18:51:21Z
dc.date.available 2023-05-10T18:51:21Z
dc.date.issued 2019
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/152756
dc.description.abstract The interaction of a poly-functional ligand derived of o-vanillin and 2-thiophenemethylamine (oVATPNH2) with transition metal ions, Cu(II) and Zn(II) leads to the formation of stable coordination compounds, namely [Cu(oVATPNH2)2] and [Zn(oVATPNH2)2]. Their crystal structures have been determined by X-ray diffraction methods. Two molecules of the deprotonated ligand acting as bidentate build a nearly square planar environment around Cu(II) and a distorted tetrahedral coordination arrangement for Zn(II). The complexes were characterized by spectroscopic techniques, including solid state FTIR, Raman, EPR and diffuse reflectance and solution UV-vis and EPR. Their thermal behavior has been analyzed by means of TGA and DTA. DFT theoretical studies, using computational methods based on DFT, were employed to assist the interpretation and assignment of spectroscopic data. Cytotoxicity assays against two human breast cancer cell lines, namely MCF-7 and MDA-MB-231, revealed an enhancement of effectiveness of the complexes as compared with both the ligand and the free metal ions. The results for the copper compound are promising, as its cytotoxic effect was stronger than the reference metallodrug cisplatin in both cancer cell lines tested. en
dc.language en es
dc.title Cu(II) and Zn(II) complexes with a poly-functional ligand derived from o-vanillin and thiophene en
dc.type Articulo es
sedici.identifier.other https://doi.org/10.1039/C8NJ06274A es
sedici.identifier.issn 1369-9261 es
sedici.title.subtitle Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells en
sedici.creator.person Rodríguez, María Rosa es
sedici.creator.person Plá, Julián del es
sedici.creator.person Balsa, Lucía Mariana es
sedici.creator.person León, Ignacio Esteban es
sedici.creator.person Piro, Oscar Enrique es
sedici.creator.person Echeverría, Gustavo Alberto es
sedici.creator.person García Tojal, Javier es
sedici.creator.person Pis Diez, Reinaldo es
sedici.creator.person Parajón Costa, Beatriz Susana es
sedici.creator.person González Baró, Ana Cecilia es
sedici.subject.materias Química es
sedici.description.fulltext true es
mods.originInfo.place Centro de Química Inorgánica es
mods.originInfo.place Instituto de Física La Plata es
sedici.subtype Preprint es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle New Journal of Chemistry es
sedici.relation.journalVolumeAndIssue vol. 43 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)