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dc.date.accessioned 2023-05-18T17:06:21Z
dc.date.available 2023-05-18T17:06:21Z
dc.date.issued 2013
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/153221
dc.description.abstract A new formulation is described based on biopolymeric microspheres containing alginate lyase (AL) and ciprofloxacin (Cip) for sustainable oral delivery in CF patients. Alginate (ALG) and high-methoxyl pectin (HMP) are selected as the biopolymers to develop a composite matrix. ALG microspheres coated with HMP and ALG-HMP blend are gelled in water/organic solvents mixtures, obtaining Cip encapsulations from 46.0 to 100.0%. ALG-HMP shows a Cip sustainable release profile and is able to encapsulate 90.0% of AL, showing 76.0% enzyme activity after release under simulated intestinal conditions. The developed system is a promising delivery carrier to treat chronic infection of Pseudomonas aeruginosa and to reduce the viscoelasticity of the mucus accumulated into intestine of CF patients. en
dc.language en es
dc.subject alginate lyase es
dc.subject Biopolymers es
dc.subject Ciprofloxacin es
dc.subject Cystic fibrosis es
dc.subject Drug delivery es
dc.title Alginate lyase and ciprofloxacin co-immobilization on biopolymeric microspheres for cystic fibrosis treatment en
dc.type Articulo es
sedici.identifier.other https://doi.org/10.1002/mabi.201300134 es
sedici.identifier.issn 1616-5195 es
sedici.creator.person Islan, Germán Abel es
sedici.creator.person Bosio, Valeria Elizabeth es
sedici.creator.person Castro, Guillermo Raúl es
sedici.subject.materias Biología es
sedici.description.fulltext true es
mods.originInfo.place Centro de Investigación y Desarrollo en Fermentaciones Industriales es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Macromolecular Bioscience es
sedici.relation.journalVolumeAndIssue vol. 13, no. 9 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)