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dc.date.accessioned | 2023-05-19T16:06:21Z | |
dc.date.available | 2023-05-19T16:06:21Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | http://sedici.unlp.edu.ar/handle/10915/153287 | |
dc.description.abstract | Phage therapy by oral administration requires enhanced resistance of phages to the harsh gastric conditions. The aim of this work is the microencapsulation of phages in natural biopolymeric matrices as a protective barrier against the gastric environment. Alginate and pectin are used as base polymers. Further emulsification with oleic acid or coating with a different biopolymer is also studied. Emulsified pectin shows the maximum encapsulation efficiency and the highest protection against acidity, leaving more than 10³ active phages after 30 min exposure at pH¼1.6, and protects phage from pepsin activity (4.2mgmL⁻¹). Non-encapsulated phages are fully inactivated at pH¼1.6 or with pepsin (0.5mgmL⁻¹) after 10 min. | en |
dc.format.extent | 1200–1208 | es |
dc.language | en | es |
dc.subject | Biocontrol | es |
dc.subject | Biological applications of polymers | es |
dc.subject | Biopolymers | es |
dc.subject | Microencapsulation | es |
dc.subject | Phages | es |
dc.title | Novel biopolymer matrices for microencapsulation of phages: enhanced protection against acidity and protease activity | en |
dc.type | Articulo | es |
sedici.identifier.other | https://doi.org/10.1002/mabi.201200109 | es |
sedici.identifier.issn | 1616-5195 | es |
sedici.creator.person | Dini, Cecilia | es |
sedici.creator.person | Islan, Germán Abel | es |
sedici.creator.person | Urraza, Patricio José de | es |
sedici.creator.person | Castro, Guillermo Raúl | es |
sedici.subject.materias | Biología | es |
sedici.description.fulltext | true | es |
mods.originInfo.place | Centro de Investigación y Desarrollo en Fermentaciones Industriales | es |
sedici.subtype | Articulo | es |
sedici.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
sedici.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
sedici.description.peerReview | peer-review | es |
sedici.relation.journalTitle | Macromolecular Bioscience | es |
sedici.relation.journalVolumeAndIssue | vol. 12, no. 9 | es |