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dc.date.accessioned 2023-05-19T16:06:21Z
dc.date.available 2023-05-19T16:06:21Z
dc.date.issued 2012
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/153287
dc.description.abstract Phage therapy by oral administration requires enhanced resistance of phages to the harsh gastric conditions. The aim of this work is the microencapsulation of phages in natural biopolymeric matrices as a protective barrier against the gastric environment. Alginate and pectin are used as base polymers. Further emulsification with oleic acid or coating with a different biopolymer is also studied. Emulsified pectin shows the maximum encapsulation efficiency and the highest protection against acidity, leaving more than 10³ active phages after 30 min exposure at pH¼1.6, and protects phage from pepsin activity (4.2mgmL⁻¹). Non-encapsulated phages are fully inactivated at pH¼1.6 or with pepsin (0.5mgmL⁻¹) after 10 min. en
dc.format.extent 1200–1208 es
dc.language en es
dc.subject Biocontrol es
dc.subject Biological applications of polymers es
dc.subject Biopolymers es
dc.subject Microencapsulation es
dc.subject Phages es
dc.title Novel biopolymer matrices for microencapsulation of phages: enhanced protection against acidity and protease activity en
dc.type Articulo es
sedici.identifier.other https://doi.org/10.1002/mabi.201200109 es
sedici.identifier.issn 1616-5195 es
sedici.creator.person Dini, Cecilia es
sedici.creator.person Islan, Germán Abel es
sedici.creator.person Urraza, Patricio José de es
sedici.creator.person Castro, Guillermo Raúl es
sedici.subject.materias Biología es
sedici.description.fulltext true es
mods.originInfo.place Centro de Investigación y Desarrollo en Fermentaciones Industriales es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Macromolecular Bioscience es
sedici.relation.journalVolumeAndIssue vol. 12, no. 9 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)