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dc.date.accessioned 2023-08-07T16:47:59Z
dc.date.available 2023-08-07T16:47:59Z
dc.date.issued 2022-08
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/155997
dc.description.abstract Despite the ever-increasing number of available options for the treatment of epilepsies and the remarkable advances on the understanding of their pathophysiology, the proportion of refractory patients has remained approximately unmodified during the last 100 years. How efficient are we translating positive outcomes from basic research to clinical trials and/or the clinical scenario? It is possible that fresh thinking and exploration of new paradigms are required to arrive at truly novel therapeutic solutions, as seemingly proven by recently approved first-in-class antiseizure medications and drug candidates undergoing late clinical trials. Here, the author discusses some approximations in line with the network pharmacology philosophy, which may result in highly innovative (and, hopefully, safer and/or more efficacious) medications for the control of seizures, as embodied with some recent examples in the field, namely tailored multi-target agents and low-affinity ligands. en
dc.format.extent S133-S141 es
dc.language en es
dc.subject disrupting innovation es
dc.subject drug discovery es
dc.subject epilepsy es
dc.subject innovation es
dc.subject low-affinity ligand es
dc.subject multi-target es
dc.subject multi-target drugs es
dc.subject network pharmacology es
dc.subject partial agonist es
dc.subject radical innovation es
dc.subject systems pharmacology es
dc.title Antiseizure medication discovery: Recent and future paradigm shifts en
dc.type Articulo es
sedici.identifier.other https://doi.org/10.1002/epi4.12581 es
sedici.identifier.issn 2470-9239 es
sedici.creator.person Talevi, Alan es
sedici.subject.materias Ciencias Exactas es
sedici.subject.materias Biología es
sedici.description.fulltext true es
mods.originInfo.place Laboratorio de Investigación y Desarrollo de Bioactivos es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Epilepsia Open es
sedici.relation.journalVolumeAndIssue vol. 7, no. S1 es

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